Tsuyoshi Miyakawa

Genetic Engineering and Functional Genomics Unit, Graduate School of Medicine, Kyoto University

Affiliated withGraduate School of Medicine, Kyoto University Fujita Health University Japan Science and Technology Agency, Core Research for Evolutionary Science and Technology (CREST)

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 5	Year
Publication title Cited by 256	2006
Publication title Cited by 526	2008
Publication title Cited by 207	2009
Publication title Cited by 94	2012
Publication title Cited by 148	2014

Other Publications

Article	Year
Transcriptomic evidence for immaturity of the prefrontal cortex in patients with schizophrenia. Molecular brain\| PubMed ID: 24886351	2014
Conditional calcineurin knockout mice exhibit multiple abnormal behaviors related to schizophrenia. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12851457	2003
Evidence for association of schizophrenia with genetic variation in the 8p21.3 gene, PPP3CC, encoding the calcineurin gamma subunit. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12851458	2003
Acceleration of visually cued conditioned fear through the auditory pathway. Nature neuroscience\| PubMed ID: 15322551	2004
The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 15537882	2004
Enhanced cocaine responsiveness and impaired motor coordination in metabotropic glutamate receptor subtype 2 knockout mice. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15753323	2005
Tight junctions in Schwann cells of peripheral myelinated axons: a lesson from claudin-19-deficient mice. The Journal of cell biology\| PubMed ID: 15883201	2005
[Stress and animal model of psychiatric disease]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica\| PubMed ID: 16272762	2005
NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21. Nature\| PubMed ID: 16554754	2006
Schizophrenia-relevant behavioral testing in rodent models: a uniquely human disorder? Biological psychiatry\| PubMed ID: 16797265	2006
Investigating gene-to-behavior pathways in psychiatric disorders: the use of a comprehensive behavioral test battery on genetically engineered mice. Annals of the New York Academy of Sciences\| PubMed ID: 17185513	2006
Sept4, a component of presynaptic scaffold and Lewy bodies, is required for the suppression of alpha-synuclein neurotoxicity. Neuron\| PubMed ID: 17296554	2007
Mouse liaison for integrative brain research. Neuroscience research\| PubMed ID: 17382419	2007
Enriched environments influence depression-related behavior in adult mice and the survival of newborn cells in their hippocampi. Behavioural brain research\| PubMed ID: 17397941	2007
Impact of brain-behavior phenotypying of genetically-engineered mice on research of neuropsychiatric disorders. Neuroscience research\| PubMed ID: 17524507	2007
Selective impairment of working memory in a mouse model of chronic cerebral hypoperfusion. Stroke; a journal of cerebral circulation\| PubMed ID: 17761909	2007
Altered sensitivities to morphine and cocaine in scaffold protein tamalin knockout mice. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17766434	2007
Genetic ablation of NMDA receptor subunit NR3B in mouse reveals motoneuronal and nonmotoneuronal phenotypes. The European journal of neuroscience\| PubMed ID: 17880385	2007
Increased social interaction in mice deficient of the striatal medium spiny neuron-specific phosphodiesterase 10A2. Journal of neurochemistry\| PubMed ID: 18088367	2008
Smaller dendritic spines, weaker synaptic transmission, but enhanced spatial learning in mice lacking Shank1. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 18272690	2008
Increased anxiety-like behavior in neuropsin (kallikrein-related peptidase 8) gene-deficient mice. Behavioral neuroscience\| PubMed ID: 18513120	2008
[Investigating genes-to-behavior pathways in psychiatric diseases: an approach using a comprehensive behavioral test battery on genetically engineered mice]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology\| PubMed ID: 18646600	2008
Mice lacking the schizophrenia-associated protein FEZ1 manifest hyperactivity and enhanced responsiveness to psychostimulants. Human molecular genetics\| PubMed ID: 18647754	2008
Identification of YWHAE, a gene encoding 14-3-3epsilon, as a possible susceptibility gene for schizophrenia. Human molecular genetics\| PubMed ID: 18658164	2008
Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain. Nature neuroscience\| PubMed ID: 18758458	2008
Alpha-CaMKII deficiency causes immature dentate gyrus, a novel candidate endophenotype of psychiatric disorders. Molecular brain\| PubMed ID: 18803808	2008
Comprehensive behavioral phenotyping of calpastatin-knockout mice. Molecular brain\| PubMed ID: 18803809	2008
Impaired long-term memory retention and working memory in sdy mutant mice with a deletion in Dtnbp1, a susceptibility gene for schizophrenia. Molecular brain\| PubMed ID: 18945333	2008
Mice lacking the kf-1 gene exhibit increased anxiety- but not despair-like behavior. Frontiers in behavioral neuroscience\| PubMed ID: 18958194	2008
Down-regulation of protocadherin-alpha A isoforms in mice changes contextual fear conditioning and spatial working memory. The European journal of neuroscience\| PubMed ID: 18973563	2008
Normal mitochondrial respiratory function is essential for spatial remote memory in mice. Molecular brain\| PubMed ID: 19087269	2008
Comprehensive behavioral phenotyping of ryanodine receptor type 3 (RyR3) knockout mice: decreased social contact duration in two social interaction tests. Frontiers in behavioral neuroscience\| PubMed ID: 19503748	2009
Abnormal social behavior, hyperactivity, impaired remote spatial memory, and increased D1-mediated dopaminergic signaling in neuronal nitric oxide synthase knockout mice. Molecular brain\| PubMed ID: 19538708	2009
Abnormal behavior in a chromosome-engineered mouse model for human 15q11-13 duplication seen in autism. Cell\| PubMed ID: 19563756	2009
Mice with altered myelin proteolipid protein gene expression display cognitive deficits accompanied by abnormal neuron-glia interactions and decreased conduction velocities. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 19571127	2009
Intrauterine environment-genome interaction and children's development (4): Brain-behavior phenotypying of genetically-engineered mice using a comprehensive behavioral test battery on resear... The Journal of toxicological sciences\| PubMed ID: 19571483	2009
Inhibition of calpain increases LIS1 expression and partially rescues in vivo phenotypes in a mouse model of lissencephaly. Nature medicine\| PubMed ID: 19734909	2009
Neural activity changes underlying the working memory deficit in alpha-CaMKII heterozygous knockout mice. Frontiers in behavioral neuroscience\| PubMed ID: 19750198	2009
KF-1 Ubiquitin Ligase: An Anxiety Suppressor. Frontiers in neuroscience\| PubMed ID: 19753093	2009
Abnormalities in brain structure and behavior in GSK-3alpha mutant mice. Molecular brain\| PubMed ID: 19925672	2009
Nardilysin regulates axonal maturation and myelination in the central and peripheral nervous system. Nature neuroscience\| PubMed ID: 19935654	2009
Ischemia-induced neurogenesis of neocortical layer 1 progenitor cells. Nature neuroscience\| PubMed ID: 20037576	2010
SDOP-DB: a comparative standardized-protocol database for mouse phenotypic analyses. Bioinformatics (Oxford, England)\| PubMed ID: 20194625	2010
Comprehensive behavioral analysis of calcium/calmodulin-dependent protein kinase IV knockout mice. PloS one\| PubMed ID: 20209163	2010
Reversal of hippocampal neuronal maturation by serotonergic antidepressants. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20404165	2010
A mouse model characterizing features of vascular dementia with hippocampal atrophy. Stroke; a journal of cerebral circulation\| PubMed ID: 20448204	2010
Case reports: Painful limbs/moving extremities: report of two cases. Clinical orthopaedics and related research\| PubMed ID: 20585912	2010
[Immature dentate gyrus as a candidate endophenotype of psychiatric disorders]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology\| PubMed ID: 20666142	2010
Behavioral profiles of three C57BL/6 substrains. Frontiers in behavioral neuroscience\| PubMed ID: 20676234	2010
Stress-evoked tyrosine phosphorylation of signal regulatory protein Î± regulates behavioral immobility in the forced swim test. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 20685990	2010
Expression of tryptophan 2,3-dioxygenase in mature granule cells of the adult mouse dentate gyrus. Molecular brain\| PubMed ID: 20815922	2010
Inactivation of fibroblast growth factor binding protein 3 causes anxiety-related behaviors. Molecular and cellular neurosciences\| PubMed ID: 20851768	2011
Right-hemispheric dominance of spatial memory in split-brain mice. Hippocampus\| PubMed ID: 21069782	2012
[Genes, behaviors and psychiatric disorders]. Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme\| PubMed ID: 21089339	2008
Decreased exploratory activity in a mouse model of 15q duplication syndrome; implications for disturbance of serotonin signaling. PloS one\| PubMed ID: 21179543	2010
The influence of chronic cerebral hypoperfusion on cognitive function and amyloid Î² metabolism in APP overexpressing mice. PloS one\| PubMed ID: 21305033	2011
Chronic treatment with fluoxetine for more than 6 weeks decreases neurogenesis in the subventricular zone of adult mice. Molecular brain\| PubMed ID: 21385396	2011
Synaptic E3 ligase SCRAPPER in contextual fear conditioning: extensive behavioral phenotyping of Scrapper heterozygote and overexpressing mutant mice. PloS one\| PubMed ID: 21390313	2011
Forebrain-specific constitutively active CaMKKÎ± transgenic mice show deficits in hippocampus-dependent long-term memory. Neurobiology of learning and memory\| PubMed ID: 21558011	2011
P301S mutant human tau transgenic mice manifest early symptoms of human tauopathies with dementia and altered sensorimotor gating. PloS one\| PubMed ID: 21698260	2011
Relaxin-3-deficient mice showed slight alteration in anxiety-related behavior. Frontiers in behavioral neuroscience\| PubMed ID: 21887138	2011
Expression of the AMPA Receptor Subunits GluR1 and GluR2 is Associated with Granule Cell Maturation in the Dentate Gyrus. Frontiers in neuroscience\| PubMed ID: 21927594	2011
DIP/WISH deficiency enhances synaptic function and performance in the Barnes maze. Molecular brain\| PubMed ID: 22018352	2011
Adenomatous polyposis coli heterozygous knockout mice display hypoactivity and age-dependent working memory deficits. Frontiers in behavioral neuroscience\| PubMed ID: 22347851	2011
Comprehensive behavioral analysis of ENU-induced Disc1-Q31L and -L100P mutant mice. BMC research notes\| PubMed ID: 22348257	2012
M4 muscarinic receptor knockout mice display abnormal social behavior and decreased prepulse inhibition. Molecular brain\| PubMed ID: 22463818	2012
α-Synuclein BAC transgenic mice as a model for Parkinson's disease manifested decreased anxiety-like behavior and hyperlocomotion. Neuroscience research\| PubMed ID: 22475625	2012
Increased astrocytic ATP release results in enhanced excitability of the hippocampus. Glia\| PubMed ID: 23018918	2013
Comprehensive behavioral analysis of pituitary adenylate cyclase-activating polypeptide (PACAP) knockout mice. Frontiers in behavioral neuroscience\| PubMed ID: 23060763	2012
Impaired synaptic clustering of postsynaptic density proteins and altered signal transmission in hippocampal neurons, and disrupted learning behavior in PDZ1 and PDZ2 ligand binding-deficien... Molecular brain\| PubMed ID: 23268962	2012
Behavioral abnormalities observed in Zfhx2-deficient mice. PloS one\| PubMed ID: 23300874	2012
Fluoxetine-induced cortical adult neurogenesis. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology\| PubMed ID: 23303069	2013
Deficiency of schnurri-2, an MHC enhancer binding protein, induces mild chronic inflammation in the brain and confers molecular, neuronal, and behavioral phenotypes related to schizophrenia. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology\| PubMed ID: 23389689	2013
Post-natal treatment by a blood-brain-barrier permeable calpain inhibitor, SNJ1945 rescued defective function in lissencephaly. Scientific reports\| PubMed ID: 23390575	2013
Synaptosomal-associated protein 25 mutation induces immaturity of the dentate granule cells of adult mice. Molecular brain\| PubMed ID: 23497716	2013
The immature dentate gyrus represents a shared phenotype of mouse models of epilepsy and psychiatric disease. Bipolar disorders\| PubMed ID: 23560889	2013
ENU-mutagenesis mice with a non-synonymous mutation in Grin1 exhibit abnormal anxiety-like behaviors, impaired fear memory, and decreased acoustic startle response. BMC research notes\| PubMed ID: 23688147	2013
Immature dentate gyrus: an endophenotype of neuropsychiatric disorders. Neural plasticity\| PubMed ID: 23840971	2013
Chronic overload of SEPT4, a parkin substrate that aggregates in Parkinson's disease, causes behavioral alterations but not neurodegeneration in mice. Molecular brain\| PubMed ID: 23938054	2013
Orexin receptor-1 in the locus coeruleus plays an important role in cue-dependent fear memory consolidation. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 24005305	2013
Point mutation in syntaxin-1A causes abnormal vesicle recycling, behaviors, and short term plasticity. The Journal of biological chemistry\| PubMed ID: 24136198	2013
Chronic fluoxetine treatment reduces parvalbumin expression and perineuronal nets in gamma-aminobutyric acidergic interneurons of the frontal cortex in adult mice. Molecular brain\| PubMed ID: 24228616	2013
In vivo evaluation of cellular activity in αCaMKII heterozygous knockout mice using manganese-enhanced magnetic resonance imaging (MEMRI). Frontiers in integrative neuroscience\| PubMed ID: 24273499	2013
PRICKLE1 interaction with SYNAPSIN I reveals a role in autism spectrum disorders. PloS one\| PubMed ID: 24312498	2013
Microendoscopy-assisted muscle-preserving interlaminar decompression for lumbar spinal stenosis: clinical results of consecutive 105 cases with more than 3-year follow-up. Spine\| PubMed ID: 24365896	2014
Mice lacking collapsin response mediator protein 1 manifest hyperactivity, impaired learning and memory, and impaired prepulse inhibition. Frontiers in behavioral neuroscience\| PubMed ID: 24409129	2013
Absence of BRINP1 in mice causes increase of hippocampal neurogenesis and behavioral alterations relevant to human psychiatric disorders. Molecular brain\| PubMed ID: 24528488	2014
Increased behavioral and neuronal responses to a hallucinogenic drug in PACAP heterozygous mutant mice. PloS one\| PubMed ID: 24586556	2014
Comprehensive behavioral analysis of cluster of differentiation 47 knockout mice. PloS one\| PubMed ID: 24586890	2014
Targeted deletion of the C-terminus of the mouse adenomatous polyposis coli tumor suppressor results in neurologic phenotypes related to schizophrenia. Molecular brain\| PubMed ID: 24678719	2014
Comprehensive behavioral study of mGluR3 knockout mice: implication in schizophrenia related endophenotypes. Molecular brain\| PubMed ID: 24758191	2014
Hippocampal neurogenesis regulates forgetting during adulthood and infancy. Science (New York, N.Y.)\| PubMed ID: 24812394	2014
Enhanced stability of hippocampal place representation caused by reduced magnesium block of NMDA receptors in the dentate gyrus. Molecular brain\| PubMed ID: 24893573	2014
Mechanisms for interferon-α-induced depression and neural stem cell dysfunction. Stem cell reports\| PubMed ID: 25068123	2014
[Immaturity of brain as an endophenotype of neuropsychiatric disorders]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology\| PubMed ID: 25076776	2014
Genomic responses in mouse models greatly mimic human inflammatory diseases. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 25092317	2015
SIRT1 overexpression ameliorates a mouse model of SOD1-linked amyotrophic lateral sclerosis via HSF1/HSP70i chaperone system. Molecular brain\| PubMed ID: 25167838	2014
Transient receptor potential ankyrin 1 in spinal cord dorsal horn is involved in neuropathic pain in nerve root constriction rats. Molecular pain\| PubMed ID: 25192906	2014
IL1RAPL1 knockout mice show spine density decrease, learning deficiency, hyperactivity and reduced anxiety-like behaviours. Scientific reports\| PubMed ID: 25312502	2014
Reply to Warren et al. and Shay et al.: Commonalities across species do exist and are potentially important. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 25540421	2015