Assam El-Osta

Department of Pathology, The University of Melbourne

Affiliated withThe University of Melbourne The Alfred Medical Research and Education Precinct University of Melbourne

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Biography

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JoVE Journal Publications

ArticleTotal : 4	Year
Publication title Cited by 23	2010
Publication title Cited by 7	2010
Publication title Cited by 7	2010
Publication title Cited by 223	2011

Other Publications

Article	Year
Precipitous release of methyl-CpG binding protein 2 and histone deacetylase 1 from the methylated human multidrug resistance gene (MDR1) on activation. Molecular and cellular biology\| PubMed ID: 11865062	2002
FMR1 silencing and the signals to chromatin: a unified model of transcriptional regulation. Biochemical and biophysical research communications\| PubMed ID: 12099676	2002
On the use of DNA methylation inhibitors and the reversal of transcriptional silencing. Blood\| PubMed ID: 12560246	2003
The rise of DNA methylation and the importance of chromatin on multidrug resistance in cancer. Experimental cell research\| PubMed ID: 14567978	2003
DNMT cooperativity--the developing links between methylation, chromatin structure and cancer. BioEssays : news and reviews in molecular, cellular and developmental biology\| PubMed ID: 14579248	2003
The rise and fall of genomic methylation in cancer. Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K\| PubMed ID: 14628069	2004
Epigenetic changes activate widespread signals in response to double-strand breaks. Cancer biology & therapy\| PubMed ID: 15136760	2004
Understanding the consequences of epigenetic mechanisms and its effects on transcription in health and disease. Cancer biology & therapy\| PubMed ID: 15326369	2004
MDR1, chemotherapy and chromatin remodeling. Cancer biology & therapy\| PubMed ID: 15326379	2004
Expression analysis of the epigenetic methyltransferases and methyl-CpG binding protein families in the normal B-cell and B-cell chronic lymphocytic leukemia (CLL). Cancer biology & therapy\| PubMed ID: 15467427	2004
Demethylation using the epigenetic modifier, 5-azacytidine, increases the efficiency of transient transfection of macrophages. Journal of lipid research\| PubMed ID: 15520456	2005
siRNAs: mechanism of RNA interference, in vivo and potential clinical applications. Cancer biology & therapy\| PubMed ID: 15539939	2004
DNA damage detection and repair, and the involvement of epigenetic states. Human mutation\| PubMed ID: 15643607	2005
Brahma links the SWI/SNF chromatin-remodeling complex with MeCP2-dependent transcriptional silencing. Nature genetics\| PubMed ID: 15696166	2005
RNA interference and potential therapeutic applications of short interfering RNAs. Cancer gene therapy\| PubMed ID: 15891770	2005
Modulation of soluble receptor for advanced glycation end products by angiotensin-converting enzyme-1 inhibition in diabetic nephropathy. Journal of the American Society of Nephrology : JASN\| PubMed ID: 15930093	2005
The histone deacetylase inhibitor, Trichostatin A, enhances radiation sensitivity and accumulation of gammaH2A.X. Cancer biology & therapy\| PubMed ID: 16082178	2005
Epigenetic changes to the MDR1 locus in response to chemotherapeutic drugs. Oncogene\| PubMed ID: 16091741	2005
Mechanisms of abnormal gene expression in tumor cells. EXS\| PubMed ID: 16383026	2006
The paradox of histone deacetylase inhibitor-mediated modulation of cellular responses to radiation. Cell cycle (Georgetown, Tex.)\| PubMed ID: 16418577	2006
The neuronal noradrenaline transporter, anxiety and cardiovascular disease. Journal of psychopharmacology (Oxford, England)\| PubMed ID: 16785272	2006
FOXO1 regulates the expression of 4E-BP1 and inhibits mTOR signaling in mammalian skeletal muscle. The Journal of biological chemistry\| PubMed ID: 17510058	2007
Clinical potential of histone deacetylase inhibitors as stand alone therapeutics and in combination with other chemotherapeutics or radiotherapy for cancer. Epigenetics : official journal of the DNA Methylation Society\| PubMed ID: 17965606	2006
The epigenetic modifier, valproic acid, enhances radiation sensitivity. Epigenetics : official journal of the DNA Methylation Society\| PubMed ID: 17965607	2006
Effect of valproic acid on radiation-induced DNA damage in euchromatic and heterochromatic compartments. Cell cycle (Georgetown, Tex.)\| PubMed ID: 18239454	2008
Epigenetic regulation and fetal programming. Best practice & research. Clinical endocrinology & metabolism\| PubMed ID: 18279777	2008
Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia. The Journal of experimental medicine\| PubMed ID: 18809715	2008
Survival motor neuron gene 2 silencing by DNA methylation correlates with spinal muscular atrophy disease severity and can be bypassed by histone deacetylase inhibition. Human molecular genetics\| PubMed ID: 18971205	2009
Human sympathetic nerve biology: parallel influences of stress and epigenetics in essential hypertension and panic disorder. Annals of the New York Academy of Sciences\| PubMed ID: 19120127	2008
Hyperglycemia induces a dynamic cooperativity of histone methylase and demethylase enzymes associated with gene-activating epigenetic marks that coexist on the lysine tail. Diabetes\| PubMed ID: 19208907	2009
The emerging role of epigenetic modifications and chromatin remodeling in spinal muscular atrophy. Journal of neurochemistry\| PubMed ID: 19383090	2009
gamma-radiation-induced gammaH2AX formation occurs preferentially in actively transcribing euchromatic loci. Cellular and molecular life sciences : CMLS\| PubMed ID: 19859659	2010
Epigenetic regulation of multidrug resistance 1 gene expression: profiling CpG methylation status using bisulphite sequencing. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 19949925	2010
Analysis of the IGF2/H19 imprinting control region uncovers new genetic defects, including mutations of OCT-binding sequences, in patients with 11p15 fetal growth disorders. Human molecular genetics\| PubMed ID: 20007505	2010
Cardiac ventricular chambers are epigenetically distinguishable. Cell cycle (Georgetown, Tex.)\| PubMed ID: 20090419	2010
Alleviating transcriptional inhibition of the norepinephrine slc6a2 transporter gene in depolarized neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 20107077	2010
GammaH2AX as a molecular marker of aging and disease. Epigenetics : official journal of the DNA Methylation Society\| PubMed ID: 20150765	2010
Downstream targets of methyl CpG binding protein 2 and their abnormal expression in the frontal cortex of the human Rett syndrome brain. BMC neuroscience\| PubMed ID: 20420693	2010
Metabolic memory and diabetic nephropathy: potential role for epigenetic mechanisms. Nature reviews. Nephrology\| PubMed ID: 20421885	2010
Glycemic memory associated epigenetic changes. Biochemical pharmacology\| PubMed ID: 20599797	2010
Trichostatin A accentuates doxorubicin-induced hypertrophy in cardiac myocytes. Aging\| PubMed ID: 20930262	2010
Epigenetic phenomena linked to diabetic complications. Nature reviews. Endocrinology\| PubMed ID: 21045787	2010
Histone modifications regulate the norepinephrine transporter gene. Cell cycle (Georgetown, Tex.)\| PubMed ID: 21088495	2010
Epigenetics: mechanisms and implications for diabetic complications. Circulation research\| PubMed ID: 21148447	2010
Atherogenic factors and their epigenetic relationships. International journal of vascular medicine\| PubMed ID: 21152193	2010
Genetic and epigenetic events in diabetic wound healing. International wound journal\| PubMed ID: 21159125	2011
Double-strand breaks and the concept of short- and long-term epigenetic memory. Chromosoma\| PubMed ID: 21174214	2011
Phosphoinositide 3-kinase as a novel functional target for the regulation of the insulin signaling pathway by SIRT1. Molecular and cellular endocrinology\| PubMed ID: 21241768	2011
Evaluation of the efficacy of radiation-modifying compounds using Î³H2AX as a molecular marker of DNA double-strand breaks. Genome integrity\| PubMed ID: 21261999	2011
Molecular model of naphthalene-induced DNA damage in the murine lung. Human & experimental toxicology\| PubMed ID: 21508073	2012
Histone deacetylase inhibitors augment doxorubicin-induced DNA damage in cardiomyocytes. Cellular and molecular life sciences : CMLS\| PubMed ID: 21584806	2011
Cardiac genes show contextual SWI/SNF interactions with distinguishable gene activities. Epigenetics : official journal of the DNA Methylation Society\| PubMed ID: 21586902	2011
Remodeling is at the heart of chromatin: the heartaches of chromatin. Epigenetics : official journal of the DNA Methylation Society\| PubMed ID: 21646860	2011
Chromatin modifying agents - the cutting edge of anticancer therapy. Drug discovery today\| PubMed ID: 21664485	2011
New insights into the pathogenesis of Beckwith-Wiedemann and Silver-Russell syndromes: contribution of small copy number variations to 11p15 imprinting defects. Human mutation\| PubMed ID: 21780245	2011
Genome-wide analysis distinguishes hyperglycemia regulated epigenetic signatures of primary vascular cells. Genome research\| PubMed ID: 21890681	2011
Genetic examination of SETD7 and SUV39H1/H2 methyltransferases and the risk of diabetes complications in patients with type 1 diabetes. Diabetes\| PubMed ID: 21896933	2011
Investigation into the biological properties of the olive polyphenol, hydroxytyrosol: mechanistic insights by genome-wide mRNA-Seq analysis. Genes & nutrition\| PubMed ID: 21953375	2011
Protective effects of valproic acid against airway hyperresponsiveness and airway remodeling in a mouse model of allergic airways disease. Epigenetics : official journal of the DNA Methylation Society\| PubMed ID: 22139576	2011
Glycemic memory. Current opinion in lipidology\| PubMed ID: 22186662	2012
Utility of Î³H2AX as a Molecular Marker of DNA Double-Strand Breaks in Nuclear Medicine: Applications to Radionuclide Therapy Employing Auger Electron-Emitting Isotopes. Current radiopharmaceuticals\| PubMed ID: 22191615	2011
Influence of Natural and Synthetic Histone Deacetylase Inhibitors on Chromatin. Antioxidants & redox signaling\| PubMed ID: 22229817	2012
Microparticles: major transport vehicles for distinct microRNAs in circulation. Cardiovascular research\| PubMed ID: 22258631	2012