Thomas Eschenhagen

Department of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf and DZHK (German Center for Cardiovascular Research)

Affiliated withUniversity Medical Center Hamburg-Eppendorf and DZHK (German Center for Cardiovascular Research)German Centre for Cardiovascular Research (DZHK)University Medical Center Hamburg-Eppendorf

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 4	Year
Publication title Cited by 4	2011
Publication title Cited by 38	2017
Publication title Cited by 16	2019
Publication title	2020

Other Publications

Article	Year
Activation of the cardiac endothelin system in left ventricular hypertrophy before onset of heart failure in TG(mREN2)27 rats. Cardiovascular research\| PubMed ID: 11827687	2002
Inhibition of left ventricular fibrosis by tranilast in rats with renovascular hypertension. Journal of hypertension\| PubMed ID: 11910312	2002
Physiological antagonism between ventricular beta 1-adrenoceptors and alpha 1-adrenoceptors but no evidence for beta 2- and beta 3-adrenoceptor function in murine heart. British journal of pharmacology\| PubMed ID: 12010770	2002
Specific beta(2)AR blocker ICI 118,551 actively decreases contraction through a G(i)-coupled form of the beta(2)AR in myocytes from failing human heart. Circulation\| PubMed ID: 12034656	2002
Cardiac ankyrin repeat protein, a negative regulator of cardiac gene expression, is augmented in human heart failure. Biochemical and biophysical research communications\| PubMed ID: 12054667	2002
Intracellular beta-blockade: overexpression of Galpha(i2) depresses the beta-adrenergic response in intact myocardium. Cardiovascular research\| PubMed ID: 12123769	2002
Effect of the CYP2D6 genotype on metoprolol metabolism persists during long-term treatment. Pharmacogenetics\| PubMed ID: 12172215	2002
Expression of ten RGS proteins in human myocardium: functional characterization of an upregulation of RGS4 in heart failure. Cardiovascular research\| PubMed ID: 12176127	2002
Cardiac tissue engineering. Transplant immunology\| PubMed ID: 12180846	2002
Augmented expression of cardiotrophin-1 in failing human hearts is accompanied by diminished glycoprotein 130 receptor protein abundance. Circulation\| PubMed ID: 12234945	2002
Cardiac grafting of engineered heart tissue in syngenic rats. Circulation\| PubMed ID: 12354725	2002
Increased frequency of cytochrome P450 2D6 poor metabolizers among patients with metoprolol-associated adverse effects. Clinical pharmacology and therapeutics\| PubMed ID: 12386645	2002
3D engineered heart tissue for replacement therapy. Basic research in cardiology\| PubMed ID: 12479248	2002
Evidence for protein phosphatase inhibitor-1 playing an amplifier role in beta-adrenergic signaling in cardiac myocytes. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 12514122	2003
Overexpression of wild-type Galpha(i)-2 suppresses beta-adrenergic signaling in cardiac myocytes. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 12631586	2003
Cardiac tissue engineering for replacement therapy. Heart failure reviews\| PubMed ID: 12878835	2003
Beta-adrenergic stimulation induces cardiac ankyrin repeat protein expression: involvement of protein kinase A and calmodulin-dependent kinase. Cardiovascular research\| PubMed ID: 14499857	2003
Heme oxygenase-1 and its reaction product, carbon monoxide, prevent inflammation-related apoptotic liver damage in mice. Hepatology (Baltimore, Md.)\| PubMed ID: 14512878	2003
Differential coupling of m-cholinoceptors to Gi/Go-proteins in failing human myocardium. Journal of molecular and cellular cardiology\| PubMed ID: 14519434	2003
What is the role of beta-adrenergic signaling in heart failure? Circulation research\| PubMed ID: 14615493	2003
Tissue engineering of aortic heart valves. Cardiovascular research\| PubMed ID: 14659789	2003
Inhibitory G-proteins and their role in desensitization of the adenylyl cyclase pathway in heart failure. Cardiovascular research\| PubMed ID: 14659793	2003
Engineered heart tissue for regeneration of diseased hearts. Biomaterials\| PubMed ID: 14697865	2004
Decreased protein and phosphorylation level of the protein phosphatase inhibitor-1 in failing human hearts. Cardiovascular research\| PubMed ID: 14732205	2004
Human homozygous R403W mutant cardiac myosin presents disproportionate enhancement of mechanical and enzymatic properties. Journal of molecular and cellular cardiology\| PubMed ID: 15010274	2004
Formation of molecular complexes by N-methyl-D-aspartate receptor subunit NR2B and ryanodine receptor 2 in neonatal rat myocard. The Journal of biological chemistry\| PubMed ID: 15010472	2004
Effects of chronic endothelin-1 stimulation on cardiac myocyte contractile function. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 15020300	2004
S100A1 gene transfer: a strategy to strengthen engineered cardiac grafts. The journal of gene medicine\| PubMed ID: 15079813	2004
Ouabain treatment is associated with upregulation of phosphatase inhibitor-1 and Na+/Ca(2+)-exchanger and beta-adrenergic sensitization in rat hearts. Biochemical and biophysical research communications\| PubMed ID: 15110776	2004
CYP2D6 genotype: impact on adverse effects and nonresponse during treatment with antidepressants-a pilot study. Clinical pharmacology and therapeutics\| PubMed ID: 15116051	2004
Norepinephrine upregulates vascular endothelial growth factor in rat cardiac myocytes by a paracrine mechanism. Angiogenesis\| PubMed ID: 15166499	2003
Effect of amiodarone on the plasma levels of metoprolol. The American journal of cardiology\| PubMed ID: 15541258	2004
Key role of myosin light chain (MLC) kinase-mediated MLC2a phosphorylation in the alpha 1-adrenergic positive inotropic effect in human atrium. Cardiovascular research\| PubMed ID: 15621049	2005
[Beta blockers in cardiac insufficiency. When, how much and which substance]. Medizinische Monatsschrift fÃ¼r Pharmazeuten\| PubMed ID: 15646690	2004
Impairment of the ubiquitin-proteasome system by truncated cardiac myosin binding protein C mutants. Cardiovascular research\| PubMed ID: 15769446	2005
Differential functional effects of two 5-HT4 receptor isoforms in adult cardiomyocytes. Journal of molecular and cellular cardiology\| PubMed ID: 15950987	2005
Endothelin-1 and isoprenaline co-stimulation causes contractile failure which is partially reversed by MEK inhibition. Cardiovascular research\| PubMed ID: 16040022	2005
Questioning the relevance of circulating cardiac progenitor cells in cardiac regeneration. Cardiovascular research\| PubMed ID: 16253213	2005
Engineering myocardial tissue. Circulation research\| PubMed ID: 16339494	2005
Alterations of the preproenkephalin system in cardiac hypertrophy and its role in atrioventricular conduction. Cardiovascular research\| PubMed ID: 16376326	2006
Atorvastatin desensitizes beta-adrenergic signaling in cardiac myocytes via reduced isoprenylation of G-protein gamma-subunits. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 16467371	2006
Electrical coupling of cardiac myocyte cell sheets to the heart. Circulation research\| PubMed ID: 16543504	2006
Engineered heart tissue grafts improve systolic and diastolic function in infarcted rat hearts. Nature medicine\| PubMed ID: 16582915	2006
Heart muscle engineering: an update on cardiac muscle replacement therapy. Cardiovascular research\| PubMed ID: 16697358	2006
Role of calcineurin and protein phosphatase-2A in the regulation of phosphatase inhibitor-1 in cardiac myocytes. Biochemical and biophysical research communications\| PubMed ID: 16774736	2006
The MLCK-mediated alpha1-adrenergic inotropic effect in atrial myocardium is negatively modulated by PKCepsilon signaling. British journal of pharmacology\| PubMed ID: 16783412	2006
Optimizing engineered heart tissue for therapeutic applications as surrogate heart muscle. Circulation\| PubMed ID: 16820649	2006
Molecular determinants of altered Ca2+ handling in human chronic atrial fibrillation. Circulation\| PubMed ID: 16894034	2006
High-dose methotrexate in pediatric acute lymphoblastic leukemia: impact of ABCC2 polymorphisms on plasma concentrations. Clinical pharmacology and therapeutics\| PubMed ID: 17112803	2006
The 2988G>A polymorphism affects splicing of a CYP2D6 minigene. Clinical pharmacology and therapeutics\| PubMed ID: 17112815	2006
Reduced contractile response to alpha1-adrenergic stimulation in atria from mice with chronic cardiac calmodulin kinase II inhibition. Journal of molecular and cellular cardiology\| PubMed ID: 17292391	2007
Regulation of cardiac cAMP synthesis and contractility by nucleoside diphosphate kinase B/G protein beta gamma dimer complexes. Circulation research\| PubMed ID: 17363702	2007
Embryonic stem cells for cardiac muscle engineering. Trends in cardiovascular medicine\| PubMed ID: 17482096	2007
Reproducibility of transthoracic echocardiography in small animals using clinical equipment. Coronary artery disease\| PubMed ID: 17496492	2007
Decreased phosphorylation levels of cardiac myosin-binding protein-C in human and experimental heart failure. Journal of molecular and cellular cardiology\| PubMed ID: 17560599	2007
Adenovirus-delivered short hairpin RNA targeting PKCalpha improves contractile function in reconstituted heart tissue. Journal of molecular and cellular cardiology\| PubMed ID: 17628588	2007
Cardiac myosin-binding protein C is required for complete relaxation in intact myocytes. Circulation research\| PubMed ID: 17823372	2007
Development of a biological ventricular assist device: preliminary data from a small animal model. Circulation\| PubMed ID: 17846298	2007
Real-time myocardial contrast echocardiography for assessing perfusion and function in healthy and infarcted wistar rats. Ultrasound in medicine & biology\| PubMed ID: 17854980	2008
Long-term beta-adrenergic stimulation leads to downregulation of protein phosphatase inhibitor-1 in the heart. European journal of heart failure\| PubMed ID: 17921049	2007
Thyroid hormone regulates developmental titin isoform transitions via the phosphatidylinositol-3-kinase/ AKT pathway. Circulation research\| PubMed ID: 18096819	2008
Inhibition of aldehyde dehydrogenase type 2 attenuates vasodilatory action of nitroglycerin in human veins. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 18272654	2008
ATP-binding cassette transporters in human heart failure. Naunyn-Schmiedeberg's archives of pharmacology\| PubMed ID: 18392808	2008
Beta-adrenergic signaling in heart failure-adapt or die. Nature medicine\| PubMed ID: 18463653	2008
The slow force response to stretch in atrial and ventricular myocardium from human heart: functional relevance and subcellular mechanisms. Progress in biophysics and molecular biology\| PubMed ID: 18466959	2008
Angiotensin II and myosin light-chain phosphorylation contribute to the stretch-induced slow force response in human atrial myocardium. Cardiovascular research\| PubMed ID: 18503051	2008
Bisoprolol vs. carvedilol in elderly patients with heart failure: rationale and design of the CIBIS-ELD trial. Clinical research in cardiology : official journal of the German Cardiac Society\| PubMed ID: 18542839	2008
Phosphatase inhibitor-1-deficient mice are protected from catecholamine-induced arrhythmias and myocardial hypertrophy. Cardiovascular research\| PubMed ID: 18689792	2008
Unloaded rat hearts in vivo express a hypertrophic phenotype of cardiac repolarization. Journal of molecular and cellular cardiology\| PubMed ID: 18721926	2008
Activation of negative regulators of the hypoxia-inducible factor (HIF) pathway in human end-stage heart failure. Biochemical and biophysical research communications\| PubMed ID: 18782560	2008
Mechanical unloading of the rat heart involves marked changes in the protein kinase-phosphatase balance. Journal of molecular and cellular cardiology\| PubMed ID: 18848565	2008
Beta-adrenergic stimulation and myocardial function in the failing heart. Heart failure reviews\| PubMed ID: 19110970	2009
Treatment with atorvastatin partially protects the rat heart from harmful catecholamine effects. Cardiovascular research\| PubMed ID: 19136528	2009
Capturing adenylyl cyclases as potential drug targets. Nature reviews. Drug discovery\| PubMed ID: 19337273	2009
A new polymorphism in human calmodulin III gene promoter is a potential modifier gene for familial hypertrophic cardiomyopathy. European heart journal\| PubMed ID: 19429631	2009
Nonsense-mediated mRNA decay and ubiquitin-proteasome system regulate cardiac myosin-binding protein C mutant levels in cardiomyopathic mice. Circulation research\| PubMed ID: 19590044	2009
The ubiquitin-proteasome system and nonsense-mediated mRNA decay in hypertrophic cardiomyopathy. Cardiovascular research\| PubMed ID: 19617224	2010
Hepatocyte growth factor or vascular endothelial growth factor gene transfer maximizes mesenchymal stem cell-based myocardial salvage after acute myocardial infarction. Circulation\| PubMed ID: 19752375	2009
Atrogin-1 and MuRF1 regulate cardiac MyBP-C levels via different mechanisms. Cardiovascular research\| PubMed ID: 19850579	2010
Constitutively active phosphatase inhibitor-1 improves cardiac contractility in young mice but is deleterious after catecholaminergic stress and with aging. The Journal of clinical investigation\| PubMed ID: 20071777	2010
Myeloperoxidase acts as a profibrotic mediator of atrial fibrillation. Nature medicine\| PubMed ID: 20305660	2010
[Vernakalant: a novel antiarrhythmic drug for the rapid conversion of atrial fibrillation to sinus rhythm]. Deutsche medizinische Wochenschrift (1946)\| PubMed ID: 20446233	2010
Development of a drug screening platform based on engineered heart tissue. Circulation research\| PubMed ID: 20448218	2010
Phosphatase-1-inhibitor-1: amplifier or attenuator of catecholaminergic stress? Basic research in cardiology\| PubMed ID: 20526608	2010
Myomasp/LRRC39, a heart- and muscle-specific protein, is a novel component of the sarcomeric M-band and is involved in stretch sensing. Circulation research\| PubMed ID: 20847312	2010
Distinction between two populations of islet-1-positive cells in hearts of different murine strains. Stem cells and development\| PubMed ID: 20942609	2011
The new HNO donor, 1-nitrosocyclohexyl acetate, increases contractile force in normal and Î²-adrenergically desensitized ventricular myocytes. Biochemical and biophysical research communications\| PubMed ID: 20946877	2010
Engineering bioartificial tracheal tissue using hybrid fibroblast-mesenchymal stem cell cultures in collagen hydrogels. Interactive cardiovascular and thoracic surgery\| PubMed ID: 21098511	2011
Is ryanodine receptor phosphorylation key to the fight or flight response and heart failure? The Journal of clinical investigation\| PubMed ID: 21099119	2010
MicroRNA-199b targets the nuclear kinase Dyrk1a in an auto-amplification loop promoting calcineurin/NFAT signalling. Nature cell biology\| PubMed ID: 21102440	2010
Common microRNA signatures in cardiac hypertrophic and atrophic remodeling induced by changes in hemodynamic load. PloS one\| PubMed ID: 21151612	2010
Cardiovascular side effects of cancer therapies: a position statement from the Heart Failure Association of the European Society of Cardiology. European journal of heart failure\| PubMed ID: 21169385	2011
Phosphatase-1 inhibitor-1 in physiological and pathological Î²-adrenoceptor signalling. Cardiovascular research\| PubMed ID: 21354993	2011
Titration to target dose of bisoprolol vs. carvedilol in elderly patients with heart failure: the CIBIS-ELD trial. European journal of heart failure\| PubMed ID: 21429992	2011
Cardiac tissue engineering: a clinical perspective. Future cardiology\| PubMed ID: 21526914	2007
The effect of mesenchymal stem cell osteoblastic differentiation on the mechanical properties of engineered bone-like tissue. Tissue engineering. Part A\| PubMed ID: 21548844	2011
Follistatin-like 1 in chronic systolic heart failure: a marker of left ventricular remodeling. Circulation. Heart failure\| PubMed ID: 21622850	2011
The beat goes on: human heart muscle from pluripotent stem cells. Circulation research\| PubMed ID: 21700948	2011
Terminal differentiation, advanced organotypic maturation, and modeling of hypertrophic growth in engineered heart tissue. Circulation research\| PubMed ID: 21921264	2011
Human engineered heart tissue as a versatile tool in basic research and preclinical toxicology. PloS one\| PubMed ID: 22028871	2011
Adrenergic stress reveals septal hypertrophy and proteasome impairment in heterozygous Mybpc3-targeted knock-in mice. Journal of muscle research and cell motility\| PubMed ID: 22076249	2011
Defective proteolytic systems in Mybpc3-targeted mice with cardiac hypertrophy. Basic research in cardiology\| PubMed ID: 22189562	2012
Localization of Islet-1-positive cells in the healthy and infarcted adult murine heart. Circulation research\| PubMed ID: 22427341	2012
Increased myofilament Ca2+ sensitivity and diastolic dysfunction as early consequences of Mybpc3 mutation in heterozygous knock-in mice. Journal of molecular and cellular cardiology\| PubMed ID: 22465693	2012
Evidence for FHL1 as a novel disease gene for isolated hypertrophic cardiomyopathy. Human molecular genetics\| PubMed ID: 22523091	2012
Complex interactions between human myoblasts and the surrounding 3D fibrin-based matrix. PloS one\| PubMed ID: 22558372	2012
Physiological aspects of cardiac tissue engineering. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 22582087	2012
Increased myocardial SERCA expression in early type 2 diabetes mellitus is insulin dependent: In vivo and in vitro data. Cardiovascular diabetology\| PubMed ID: 22621761	2012
Progesterone receptor variants associated with the PROGINS haplotype exhibit functional properties similar to those of wild-type progesterone receptor. Pharmacogenetics and genomics\| PubMed ID: 22722322	2012
The German Centre for Cardiovascular Research. European heart journal\| PubMed ID: 22893891	2012
Increased afterload induces pathological cardiac hypertrophy: a new in vitro model. Basic research in cardiology\| PubMed ID: 23099820	2012
A novel genetic variant in the transcription factor Islet-1 exerts gain of function on myocyte enhancer factor 2C promoter activity. European journal of heart failure\| PubMed ID: 23152444	2013
Pharmacological characterization of 1-nitrosocyclohexyl acetate, a long-acting nitroxyl donor that shows vasorelaxant and antiaggregatory effects. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 23211362	2013
New tissue for failing hearts. European journal of heart failure\| PubMed ID: 23243121	2013
A frequent gene polymorphism affecting the heart-rate response to carvedilol. Pharmacogenomics\| PubMed ID: 23327570	2013
[Personalized therapy in cardiology. Biomarkers, pharmacogenetics and therapy of monogenic diseases]. Der Internist\| PubMed ID: 23371262	2013
Parthenogenetic stem cells for tissue-engineered heart repair. The Journal of clinical investigation\| PubMed ID: 23434590	2013
PDE4 in the human heart - major player or little helper? British journal of pharmacology\| PubMed ID: 23489196	2013
Nicotinic acid adenine dinucleotide phosphate (NAADP)-mediated calcium signaling and arrhythmias in the heart evoked by β-adrenergic stimulation. The Journal of biological chemistry\| PubMed ID: 23564460	2013
Impact of ANKRD1 mutations associated with hypertrophic cardiomyopathy on contraction parameters of engineered heart tissue. Basic research in cardiology\| PubMed ID: 23572067	2013
Heterozygous LmnadelK32 mice develop dilated cardiomyopathy through a combined pathomechanism of haploinsufficiency and peptide toxicity. Human molecular genetics\| PubMed ID: 23575224	2013
Development of a colorimetric and a fluorescence phosphatase-inhibitor assay suitable for drug discovery approaches. Journal of biomolecular screening\| PubMed ID: 23606651	2013
Rescue of cardiomyopathy through U7snRNA-mediated exon skipping in Mybpc3-targeted knock-in mice. EMBO molecular medicine\| PubMed ID: 23716398	2013
Phosphodiesterase-2 is Upregulated in Human Failing Hearts and Blunts Î²-Adrenergic Responses in Cardiomyocytes. Journal of the American College of Cardiology\| PubMed ID: 23810893	2013
Repair of Mybpc3 mRNA by 5'-trans-splicing in a Mouse Model of Hypertrophic Cardiomyopathy. Molecular therapy. Nucleic acids\| PubMed ID: 23820890	2013
Contractile abnormalities and altered drug response in engineered heart tissue from Mybpc3-targeted knock-in mice. Journal of molecular and cellular cardiology\| PubMed ID: 23896226	2013
Functional microRNA library screening identifies the hypoxamir miR-24 as a potent regulator of smooth muscle cell proliferation and vascularization. Antioxidants & redox signaling\| PubMed ID: 24063572	2014
Melusin protects from cardiac rupture and improves functional remodelling after myocardial infarction. Cardiovascular research\| PubMed ID: 24130190	2014
In vitro perfusion of engineered heart tissue through endothelialized channels. Tissue engineering. Part A\| PubMed ID: 24156346	2014
Nfat and miR-25 cooperate to reactivate the transcription factor Hand2 in heart failure. Nature cell biology\| PubMed ID: 24161931	2013
B-scan ultrasonographic monitoring of orthotopic xenografted plexiform neurofibroma in mice. In vivo (Athens, Greece)\| PubMed ID: 24292574	2013
[Interview by Anne-Katrin Döbler]. Deutsche medizinische Wochenschrift (1946)\| PubMed ID: 24350367	2013
Paradoxical effects on force generation after efficient β1-adrenoceptor knockdown in reconstituted heart tissue. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 24431469	2014
Cardiac tissue engineering: state of the art. Circulation research\| PubMed ID: 24436431	2014
Automated analysis of contractile force and Ca2+ transients in engineered heart tissue. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 24585781	2014
Myocardial tissue engineering: in vitro models. Cold Spring Harbor perspectives in medicine\| PubMed ID: 24591534	2014
Dichloroacetate prevents restenosis in preclinical animal models of vessel injury. Nature\| PubMed ID: 24747400	2014
Functional improvement and maturation of rat and human engineered heart tissue by chronic electrical stimulation. Journal of molecular and cellular cardiology\| PubMed ID: 24852842	2014
Guanabenz interferes with ER stress and exerts protective effects in cardiac myocytes. PloS one\| PubMed ID: 24892553	2014
Prostaglandin E2 does not attenuate adrenergic-induced cardiac contractile response. Naunyn-Schmiedeberg's archives of pharmacology\| PubMed ID: 24974239	2014
Generation of strip-format fibrin-based engineered heart tissue (EHT). Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 25070332	2014
Cardiac arrhythmia induced by genetic silencing of 'funny' (f) channels is rescued by GIRK4 inactivation. Nature communications\| PubMed ID: 25144323	2014
The continuum of personalized cardiovascular medicine: a position paper of the European Society of Cardiology. European heart journal\| PubMed ID: 25148837	2014
Effects of proarrhythmic drugs on relaxation time and beating pattern in rat engineered heart tissue. Basic research in cardiology\| PubMed ID: 25209140	2014
FHL2 expression and variants in hypertrophic cardiomyopathy. Basic research in cardiology\| PubMed ID: 25358972	2014
Development of phosphatase inhibitor-1 peptides acting as indirect activators of phosphatase 1. Naunyn-Schmiedeberg's archives of pharmacology\| PubMed ID: 25416155	2015
Assessment of DNA synthesis in Islet-1⁺ cells in the adult murine heart. Biochemical and biophysical research communications\| PubMed ID: 25450620	2015
Mybpc3 gene therapy for neonatal cardiomyopathy enables long-term disease prevention in mice. Nature communications\| PubMed ID: 25463264	2014
Modelling sarcomeric cardiomyopathies in the dish: from human heart samples to iPSC cardiomyocytes. Cardiovascular research\| PubMed ID: 25618410	2015
Deciphering the microRNA signature of pathological cardiac hypertrophy by engineered heart tissue- and sequencing-technology. Journal of molecular and cellular cardiology\| PubMed ID: 25633833	2015
Prolonged action potentials in HCM-derived iPSC--biology or artefact? Cardiovascular research\| PubMed ID: 25691543	2015
LQT1-phenotypes in hiPSC: Are we measuring the right thing? Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 25795242	2015
Immunobiology of fibrin-based engineered heart tissue. Stem cells translational medicine\| PubMed ID: 25947338	2015
Human engineered heart tissue as a model system for drug testing. Advanced drug delivery reviews\| PubMed ID: 26026976	2016
The E3 ubiquitin ligase Asb2β is downregulated in a mouse model of hypertrophic cardiomyopathy and targets desmin for proteasomal degradation. Journal of molecular and cellular cardiology\| PubMed ID: 26343497	2015
Development of Long Noncoding RNA-Based Strategies to Modulate Tissue Vascularization. Journal of the American College of Cardiology\| PubMed ID: 26516004	2015
β 1 Adrenoceptor antagonistic effects of the supposedly selective β 2 adrenoceptor antagonist ICI 118,551 on the positive inotropic effect of adrenaline in murine hearts. Pharmacology research & perspectives\| PubMed ID: 26516580	2015
Pharmacokinetics of the Experimental Non-Nucleosidic DNA Methyl Transferase Inhibitor N-Phthalyl-L-Tryptophan (RG 108) in Rats. Basic & clinical pharmacology & toxicology\| PubMed ID: 26525153	2016
Ranolazine antagonizes catecholamine-induced dysfunction in isolated cardiomyocytes, but lacks long-term therapeutic effects in vivo in a mouse model of hypertrophic cardiomyopathy. Cardiovascular research\| PubMed ID: 26531128	2016
General practitioners' adherence to chronic heart failure guidelines regarding medication: the GP-HF study. Clinical research in cardiology : official journal of the German Cardiac Society\| PubMed ID: 26552905	2016
Heart regeneration. Biochimica et biophysica acta\| PubMed ID: 26597703	2016
Knock-out of nexilin in mice leads to dilated cardiomyopathy and endomyocardial fibroelastosis. Basic research in cardiology\| PubMed ID: 26659360	2016
DNA methylation in an engineered heart tissue model of cardiac hypertrophy: common signatures and effects of DNA methylation inhibitors. Basic research in cardiology\| PubMed ID: 26680771	2016
Spontaneous Formation of Extensive Vessel-Like Structures in Murine Engineered Heart Tissue. Tissue engineering. Part A\| PubMed ID: 26763667	2016
S-glutathiolation impairs phosphoregulation and function of cardiac myosin-binding protein C in human heart failure. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 26839380	2016
Analysis of Tyrosine Kinase Inhibitor-Mediated Decline in Contractile Force in Rat Engineered Heart Tissue. PloS one\| PubMed ID: 26840448	2016
A New Animal Model for Investigation of Mechanical Unloading in Hypertrophic and Failing Hearts: Combination of Transverse Aortic Constriction and Heterotopic Heart Transplantation. PloS one\| PubMed ID: 26841021	2016
Myocardial tissue engineering for cardiac repair. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation\| PubMed ID: 26856673	2016
Ataxin-10 is part of a cachexokine cocktail triggering cardiac metabolic dysfunction in cancer cachexia. Molecular metabolism\| PubMed ID: 26909315	2016
Position Paper of the European Society of Cardiology Working Group Cellular Biology of the Heart: cell-based therapies for myocardial repair and regeneration in ischemic heart disease and he... European heart journal\| PubMed ID: 27055812	2016
Comparison of the effects of a truncating and a missense MYBPC3 mutation on contractile parameters of engineered heart tissue. Journal of molecular and cellular cardiology\| PubMed ID: 27108529	2016
Human Engineered Heart Tissue: Analysis of Contractile Force. Stem cell reports\| PubMed ID: 27211213	2016
Outcomes of Patients in Long-Term Opioid Maintenance Treatment. Substance use & misuse\| PubMed ID: 27355105	2016
[Not Available]. MMW Fortschritte der Medizin\| PubMed ID: 27372484	2008
Block of Na(+)/Ca(2+) exchanger by SEA0400 in human right atrial preparations from patients in sinus rhythm and in atrial fibrillation. European journal of pharmacology\| PubMed ID: 27373849	2016
Exogenous Nitric Oxide Protects Human Embryonic Stem Cell-Derived Cardiomyocytes against Ischemia/Reperfusion Injury. Oxidative medicine and cellular longevity\| PubMed ID: 27403231	2016
Is Stimulation of Cardiomyocyte Renewal a Facette of Reversible Catecholamine Toxicity? Circulation research\| PubMed ID: 27635079	2016
Ca(2+)-Currents in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Effects of Two Different Culture Conditions. Frontiers in pharmacology\| PubMed ID: 27672365	2016
Cardiac repair in guinea pigs with human engineered heart tissue from induced pluripotent stem cells. Science translational medicine\| PubMed ID: 27807283	2016
Towards a Tissue-Engineered Contractile Fontan-Conduit: The Fate of Cardiac Myocytes in the Subpulmonary Circulation. PloS one\| PubMed ID: 27875570	2016
Epigallocatechin-3-Gallate Accelerates Relaxation and Ca(2+) Transient Decay and Desensitizes Myofilaments in Healthy and Mybpc3-Targeted Knock-in Cardiomyopathic Mice. Frontiers in physiology\| PubMed ID: 27994558	2016
Diltiazem prevents stress-induced contractile deficits in cardiomyocytes, but does not reverse the cardiomyopathy phenotype in Mybpc3-knock-in mice. The Journal of physiology\| PubMed ID: 28090637	2017
Thymosin β4 Improves Differentiation and Vascularization of EHTs. Stem cells international\| PubMed ID: 28191018	2017
Engineering Cardiac Muscle Tissue: A Maturating Field of Research. Circulation research\| PubMed ID: 28450366	2017
Blinded Contractility Analysis in hiPSC-Cardiomyocytes in Engineered Heart Tissue Format: Comparison With Human Atrial Trabeculae. Toxicological sciences : an official journal of the Society of Toxicology\| PubMed ID: 28453742	2017
Differentiation of cardiomyocytes and generation of human engineered heart tissue. Nature protocols\| PubMed ID: 28492526	2017
Evaluation of MYBPC3 trans-Splicing and Gene Replacement as Therapeutic Options in Human iPSC-Derived Cardiomyocytes. Molecular therapy. Nucleic acids\| PubMed ID: 28624223	2017
Cardiomyocyte Regeneration: A Consensus Statement. Circulation\| PubMed ID: 28684531	2017
Human iPSC-derived cardiomyocytes cultured in 3D engineered heart tissue show physiological upstroke velocity and sodium current density. Scientific reports\| PubMed ID: 28710467	2017
Prominent differences in left ventricular performance and myocardial properties between right ventricular and left ventricular-based pacing modes in rats. Scientific reports\| PubMed ID: 28725029	2017
I-1-deficiency negatively impacts survival in a cardiomyopathy mouse model. International journal of cardiology. Heart & vasculature\| PubMed ID: 28785686	2015
Cardiovascular Research in Germany. Circulation research\| PubMed ID: 28819038	2017
MUSCLEMOTION: A Versatile Open Software Tool to Quantify Cardiomyocyte and Cardiac Muscle Contraction In Vitro and In Vivo. Circulation research\| PubMed ID: 29282212	2018
Low Resting Membrane Potential and Low Inward Rectifier Potassium Currents Are Not Inherent Features of hiPSC-Derived Cardiomyocytes. Stem cell reports\| PubMed ID: 29429959	2018
Contractile Work Contributes to Maturation of Energy Metabolism in hiPSC-Derived Cardiomyocytes. Stem cell reports\| PubMed ID: 29503093	2018
[Cardiology 2018 : From basic science to high efficiency medicine]. Herz\| PubMed ID: 29516153	2018
A new concept of fibroblast dynamics in post-myocardial infarction remodeling. The Journal of clinical investigation\| PubMed ID: 29664015	2018
Three-Dimensional Human iPSC-Derived Artificial Skeletal Muscles Model Muscular Dystrophies and Enable Multilineage Tissue Engineering. Cell reports\| PubMed ID: 29669293	2018
CRISPR/Cas9 editing in human pluripotent stem cell-cardiomyocytes highlights arrhythmias, hypocontractility, and energy depletion as potential therapeutic targets for hypertrophic cardiomyop... European heart journal\| PubMed ID: 29741611	2018
Pharmacological inhibition of DNA methylation attenuates pressure overload-induced cardiac hypertrophy in rats. Journal of molecular and cellular cardiology\| PubMed ID: 29792884	2018
No effect of thymosin beta-4 on the expression of the transcription factor Islet-1 in the adult murine heart. Pharmacology research & perspectives\| PubMed ID: 29864245	2018
Clonal dynamics studied in cultured induced pluripotent stem cells reveal major growth imbalances within a few weeks. Stem cell research & therapy\| PubMed ID: 29914569	2018
Exaggerated Cardiotoxicity of Sunitinib in Stressed 3-Dimensional Heart Muscles. JACC. Basic to translational science\| PubMed ID: 30062213	2018
From basic science to high performance medicine. European heart journal\| PubMed ID: 30165623	2018
Rat atrial engineered heart tissue: a new in vitro model to study atrial biology. Basic research in cardiology\| PubMed ID: 30178427	2018
Satellite cells delivered in their niche efficiently generate functional myotubes in three-dimensional cell culture. PloS one\| PubMed ID: 30222770	2018
Treatments targeting inotropy. European heart journal\| PubMed ID: 30295807	2019
Cardiomyopathy phenotypes in human-induced pluripotent stem cell-derived cardiomyocytes-a systematic review. Pflugers Archiv : European journal of physiology\| PubMed ID: 30324321	2018
Piezo-bending actuators for isometric or auxotonic contraction analysis of engineered heart tissue. Journal of tissue engineering and regenerative medicine\| PubMed ID: 30334614	2019
Normalization of force to muscle cross-sectional area: A helpful attempt to reduce data scattering in contractility studies? Acta physiologica (Oxford, England)\| PubMed ID: 30338659	2018
Atrial-like Engineered Heart Tissue: An In Vitro Model of the Human Atrium. Stem cell reports\| PubMed ID: 30416051	2018
Mechanistic role of the CREB-regulated transcription coactivator 1 in cardiac hypertrophy. Journal of molecular and cellular cardiology\| PubMed ID: 30521840	2019
ESC Working Group on Cellular Biology of the Heart: position paper for Cardiovascular Research: tissue engineering strategies combined with cell therapies for cardiac repair in ischaemic hea... Cardiovascular research\| PubMed ID: 30657875	2019
Toward Second-Generation Cardiomyogenic and Anti-cardiofibrotic 1,4-Dihydropyridine-Class TGFβ Inhibitors. ChemMedChem\| PubMed ID: 30768867	2019
Heart Repair With Myocytes. Circulation research\| PubMed ID: 30870126	2019
Dissecting hiPSC-CM pacemaker function in a cardiac organoid model. Biomaterials\| PubMed ID: 30933775	2019
Analysis of fibrosis in control or pressure overloaded rat hearts after mechanical unloading by heterotopic heart transplantation. Scientific reports\| PubMed ID: 30952943	2019
Human pluripotent stem cell-derived cardiomyocytes for studying energy metabolism. Biochimica et biophysica acta. Molecular cell research\| PubMed ID: 30954570	2020
Human iPS cell-derived engineered heart tissue does not affect ventricular arrhythmias in a guinea pig cryo-injury model. Scientific reports\| PubMed ID: 31285568	2019
Author Correction: Differentiation of cardiomyocytes and generation of human engineered heart tissue. Nature protocols\| PubMed ID: 31384055	2019
Blockade of miR-140-3p prevents functional deterioration in afterload-enhanced engineered heart tissue. Scientific reports\| PubMed ID: 31391475	2019
Unlocking Personalized Biomedicine and Drug Discovery with Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes: Fit for Purpose or Forever Elusive? Annual review of pharmacology and toxicology\| PubMed ID: 31506008	2020
Simultaneous measurement of excitation-contraction coupling parameters identifies mechanisms underlying contractile responses of hiPSC-derived cardiomyocytes. Nature communications\| PubMed ID: 31541103	2019
Chronic intermittent tachypacing by an optogenetic approach induces arrhythmia vulnerability in human engineered heart tissue. Cardiovascular research\| PubMed ID: 31598634	2019
Long Noncoding RNA-Enriched Vesicles Secreted by Hypoxic Cardiomyocytes Drive Cardiac Fibrosis. Molecular therapy. Nucleic acids\| PubMed ID: 31634682	2019
A magnetics-based approach for fine-tuning afterload in engineered heart tissues. ACS biomaterials science & engineering\| PubMed ID: 31637285	2019
Disease modeling of a mutation in α-actinin 2 guides clinical therapy in hypertrophic cardiomyopathy. EMBO molecular medicine\| PubMed ID: 31680489	2019
Phosphomimetic cardiac myosin-binding protein C partially rescues a cardiomyopathy phenotype in murine engineered heart tissue. Scientific reports\| PubMed ID: 31796859	2019
Force and Calcium Transients Analysis in Human Engineered Heart Tissues Reveals Positive Force-Frequency Relation at Physiological Frequency. Stem cell reports\| PubMed ID: 31956082	2020
Case Report on: Very Early Afterdepolarizations in HiPSC-Cardiomyocytes-An Artifact by Big Conductance Calcium Activated Potassium Current (I). Cells\| PubMed ID: 31968557	2020
Regulation of I and force by PDEs in human-induced pluripotent stem cell-derived cardiomyocytes. British journal of pharmacology\| PubMed ID: 32092149	2020
An epidemiological study exploring a possible impact of treatment with ACE inhibitors or angiotensin receptor blockers on ACE2 plasma concentrations. Journal of molecular and cellular cardiology\| PubMed ID: 32268149	2020
Aging-regulated anti-apoptotic long non-coding RNA Sarrah augments recovery from acute myocardial infarction. Nature communications\| PubMed ID: 32341350	2020
Toward standardization of echocardiography for the evaluation of left ventricular function in adult rodents: a position paper of the ESC Working Group on Myocardial Function. Cardiovascular research\| PubMed ID: 32365197	2020