Roger J. Hajjar

Cardiovascular Research Center, Mount Sinai School of Medicine

Affiliated withMount Sinai School of Medicine

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 3	Year
Publication title Cited by 21	2011
Publication title Cited by 7	2020
Publication title Cited by 27	2019

Other Publications

Article	Year
Targeting phospholamban by gene transfer in human heart failure. Circulation\| PubMed ID: 11864915	2002
Novel technique of aortic banding followed by gene transfer during hypertrophy and heart failure. Physiological genomics\| PubMed ID: 11948290	2002
Functional consequences of caspase activation in cardiac myocytes. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 11972044	2002
Effects of Na(+)/Ca(2+)-exchanger overexpression on excitation-contraction coupling in adult rabbit ventricular myocytes. Journal of molecular and cellular cardiology\| PubMed ID: 11991729	2002
Type 1 phosphatase, a negative regulator of cardiac function. Molecular and cellular biology\| PubMed ID: 12024026	2002
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 17-2002. A 55-year-old man with second-degree atrioventricular block and chest pain. The New England journal of medicine\| PubMed ID: 12037154	2002
Titin isoform switch in ischemic human heart disease. Circulation\| PubMed ID: 12221049	2002
New efficient catheter-based system for myocardial gene delivery. Circulation\| PubMed ID: 12356625	2002
Adrenergic-receptor polymorphisms and heart failure. The New England journal of medicine\| PubMed ID: 12374881	2002
Interaction between increased SERCA2a activity and beta -adrenoceptor stimulation in adult rabbit myocytes. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 12388307	2002
Targeting Ca2+ cycling proteins and the action potential in heart failure by gene transfer. Basic research in cardiology\| PubMed ID: 12479247	2002
Myofibrillar responsiveness to cAMP, PKA, and caffeine in an animal model of heart failure. Biochemical and biophysical research communications\| PubMed ID: 12504124	2003
Targeting calcium cycling proteins in heart failure through gene transfer. The Journal of physiology\| PubMed ID: 12509478	2003
Modulating signaling pathways in hypertrophy and heart failure by gene transfer. Journal of cardiac failure\| PubMed ID: 12555151	2002
Efficient viral gene transfer to rodent hearts in vivo. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 12597008	2003
Decreased efficiency of adenovirus-mediated gene transfer in aging cardiomyocytes. Circulation\| PubMed ID: 12615797	2003
Targeting signaling pathways in heart failure by gene transfer. Current atherosclerosis reports\| PubMed ID: 12667429	2003
Genetic editing of dysfunctional myocardium. The Medical clinics of North America\| PubMed ID: 12693739	2003
Chronic treatment with carvedilol improves ventricular function and reduces myocyte apoptosis in an animal model of heart failure. BMC physiology\| PubMed ID: 12873352	2003
Functional near-infrared fluorescence imaging for cardiac surgery and targeted gene therapy. Molecular imaging\| PubMed ID: 12940233	2002
Gene therapy for the treatment of heart failure--calcium signaling. Seminars in thoracic and cardiovascular surgery\| PubMed ID: 12973704	2003
Apoptosis in heart failure and the senescent heart. Cardiovascular toxicology\| PubMed ID: 14555785	2003
Damped elastic recoil of the titin spring in myofibrils of human myocardium. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 14563922	2003
Contractile effects of adenovirally-mediated increases in SERCA2a activity: a comparison between adult rat and rabbit ventricular myocytes. Molecular and cellular biochemistry\| PubMed ID: 14575311	2003
Titin--springing back to youth? Science of aging knowledge environment : SAGE KE\| PubMed ID: 14603021	2002
Reversal of cardiac dysfunction after long-term expression of SERCA2a by gene transfer in a pre-clinical model of heart failure. Journal of the American College of Cardiology\| PubMed ID: 18342232	2008
Abrogation of ventricular arrhythmias in a model of ischemia and reperfusion by targeting myocardial calcium cycling. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15044708	2004
Gene transfer in cardiac myocytes. The Surgical clinics of North America\| PubMed ID: 15053187	2004
Gene transfer of parvalbumin improves diastolic dysfunction in senescent myocytes. Circulation\| PubMed ID: 15173024	2004
Transcriptional changes following restoration of SERCA2a levels in failing rat hearts. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 15247151	2004
Cardiac-specific gene expression facilitated by an enhanced myosin light chain promoter. Molecular imaging\| PubMed ID: 15296671	2004
Antisense strategies for treatment of heart failure. Methods in molecular medicine\| PubMed ID: 15375313	2005
Targeted gene transfer in heart failure: implications for novel gene identification. Current opinion in molecular therapeutics\| PubMed ID: 15468597	2004
In vivo cardiac gene transfer of Kv4.3 abrogates the hypertrophic response in rats after aortic stenosis. Circulation\| PubMed ID: 15557376	2004
In vivo tracking of stem cells for clinical trials in cardiovascular disease. Circulation\| PubMed ID: 15557385	2004
Inhibition of ErbB2 causes mitochondrial dysfunction in cardiomyocytes: implications for herceptin-induced cardiomyopathy. Journal of the American College of Cardiology\| PubMed ID: 15582322	2004
Genetic maneuvers to ameliorate ventricular function in heart failure: therapeutic potential and future implications. Expert review of cardiovascular therapy\| PubMed ID: 15723577	2005
Mesenchymal stem cells in the infarcted heart. Coronary artery disease\| PubMed ID: 15735401	2005
Enhancement of cardiac function and suppression of heart failure progression by inhibition of protein phosphatase 1. Circulation research\| PubMed ID: 15746443	2005
Increased leakage of sarcoplasmic reticulum Ca2+ contributes to abnormal myocyte Ca2+ handling and shortening in sepsis. Critical care medicine\| PubMed ID: 15753753	2005
In vivo gene transfer of parvalbumin improves diastolic function in aged rat hearts. Cardiovascular research\| PubMed ID: 15820200	2005
Catheter-based ventricle-coronary vein bypass. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions\| PubMed ID: 15822113	2005
Altered Ca2+ sparks and gating properties of ryanodine receptors in aging cardiomyocytes. Cell calcium\| PubMed ID: 15862349	2005
Catheter-based antegrade intracoronary viral gene delivery with coronary venous blockade. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 15897329	2005
Angiotensin II-induced negative inotropy in rat ventricular myocytes: role of reactive oxygen species and p38 MAPK. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 16055523	2006
Sarco/endoplasmic reticulum Ca2+-ATPase gene transfer reduces vascular smooth muscle cell proliferation and neointima formation in the rat. Circulation research\| PubMed ID: 16081870	2005
In vivo volumetric analysis of coronary stent using optical coherence tomography with a novel balloon occlusion-flushing catheter: a comparison with intravascular ultrasound. Ultrasound in medicine & biology\| PubMed ID: 16223637	2005
Tracking stem cells in the cardiovascular system. Trends in cardiovascular medicine\| PubMed ID: 16297767	2005
Magnetic resonance assessment of myocardial perfusion via catheter-based ventricle-coronary vein bypass in porcine myocardial infarction model. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions\| PubMed ID: 16345049	2006
Gene and cell therapy in heart failure. Le Journal mÃ©dical libanais. The Lebanese medical journal\| PubMed ID: 16398210	2005
Xanthine oxidase inhibition and heart failure: novel therapeutic strategy for ventricular dysfunction? Circulation research\| PubMed ID: 16456108	2006
Mechanical and metabolic rescue in a type II diabetes model of cardiomyopathy by targeted gene transfer. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 16503203	2006
SERCA2a in heart failure: role and therapeutic prospects. Journal of bioenergetics and biomembranes\| PubMed ID: 16691468	2005
PICOT inhibits cardiac hypertrophy and enhances ventricular function and cardiomyocyte contractility. Circulation research\| PubMed ID: 16809552	2006
Delayed erythropoietin therapy reduces post-MI cardiac remodeling only at a dose that mobilizes endothelial progenitor cells. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 16997893	2007
CXCR4 modulates contractility in adult cardiac myocytes. Journal of molecular and cellular cardiology\| PubMed ID: 17010372	2006
Transcoronary gene transfer of SERCA2a increases coronary blood flow and decreases cardiomyocyte size in a type 2 diabetic rat model. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 17012346	2007
Localization and quantification of platelet-rich thrombi in large blood vessels with near-infrared fluorescence imaging. Circulation\| PubMed ID: 17179017	2007
Comparison of nonuniform rotational distortion between mechanical IVUS and OCT using a phantom model. Ultrasound in medicine & biology\| PubMed ID: 17189048	2007
CaMKII inhibition protects against necrosis and apoptosis in irreversible ischemia-reperfusion injury. Cardiovascular research\| PubMed ID: 17217936	2007
Targeted gene transfer increases contractility and decreases oxygen cost of contractility in normal rat hearts. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 17220178	2007
Mechanisms of abnormal calcium homeostasis in mutations responsible for catecholaminergic polymorphic ventricular tachycardia. Circulation research\| PubMed ID: 17234962	2007
Toll-like receptor 2 activation by bacterial peptidoglycan-associated lipoprotein activates cardiomyocyte inflammation and contractile dysfunction. Critical care medicine\| PubMed ID: 17255871	2007
Restoration of mechanical and energetic function in failing aortic-banded rat hearts by gene transfer of calcium cycling proteins. Journal of molecular and cellular cardiology\| PubMed ID: 17300800	2007
Gene profiling during regression of pressure overload-induced cardiac hypertrophy. Physiological genomics\| PubMed ID: 17327491	2007
Transgenic models of heart failure: elucidation of the molecular mechanisms of heart disease. Heart failure clinics\| PubMed ID: 17386848	2005
Targeting genes and cells in the progression to heart failure. Heart failure clinics\| PubMed ID: 17386853	2005
Gene therapy in the treatment of heart failure. Physiology (Bethesda, Md.)\| PubMed ID: 17420300	2007
In vivo tracking in cardiac stem cell-based therapy. Progress in cardiovascular diseases\| PubMed ID: 17498521	2007
Periostin induces proliferation of differentiated cardiomyocytes and promotes cardiac repair. Nature medicine\| PubMed ID: 17632525	2007
Early repair of moderate ischemic mitral regurgitation reverses left ventricular remodeling: a functional and molecular study. Circulation\| PubMed ID: 17846319	2007
Preservation of mechanical and energetic function after adenoviral gene transfer in normal rat hearts. Clinical and experimental pharmacology & physiology\| PubMed ID: 17973872	2007
Combining neuroendocrine inhibitors in heart failure: reflections on safety and efficacy. The American journal of medicine\| PubMed ID: 18060931	2007
Cardiac sodium channel gene variants and sudden cardiac death in women. Circulation\| PubMed ID: 18071069	2008
A novel mutant cardiac troponin C disrupts molecular motions critical for calcium binding affinity and cardiomyocyte contractility. Biophysical journal\| PubMed ID: 18212018	2008
Mitral regurgitation augments post-myocardial infarction remodeling failure of hypertrophic compensation. Journal of the American College of Cardiology\| PubMed ID: 18222360	2008
PICOT attenuates cardiac hypertrophy by disrupting calcineurin-NFAT signaling. Circulation research\| PubMed ID: 18258855	2008
Human cardiac-specific cDNA array for idiopathic dilated cardiomyopathy: sex-related differences. Physiological genomics\| PubMed ID: 18303083	2008
Progressive nature of chronic mitral regurgitation and the role of tissue Doppler-derived indexes. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 18326805	2008
Fingerprint profile of alcohol-associated heart failure in human hearts. Alcoholism, clinical and experimental research\| PubMed ID: 18336640	2008
Intracellular devastation in heart failure. Heart failure reviews\| PubMed ID: 18347978	2008
Quantitation of CXCR4 expression in myocardial infarction using 99mTc-labeled SDF-1alpha. Journal of nuclear medicine : official publication, Society of Nuclear Medicine\| PubMed ID: 18483105	2008
Design of a phase 1/2 trial of intracoronary administration of AAV1/SERCA2a in patients with heart failure. Journal of cardiac failure\| PubMed ID: 18514926	2008
Role of resistin in cardiac contractility and hypertrophy. Journal of molecular and cellular cardiology\| PubMed ID: 18597775	2008
Imaging in cardiac cell-based therapy: in vivo tracking of the biological fate of therapeutic cells. Nature clinical practice. Cardiovascular medicine\| PubMed ID: 18641613	2008
Prevention of ventricular arrhythmias with sarcoplasmic reticulum Ca2+ ATPase pump overexpression in a porcine model of ischemia reperfusion. Circulation\| PubMed ID: 18645052	2008
The cardiac sarcoplasmic/endoplasmic reticulum calcium ATPase: a potent target for cardiovascular diseases. Nature clinical practice. Cardiovascular medicine\| PubMed ID: 18665137	2008
Ventricular arrhythmias after left ventricular assist device implantation. Pacing and clinical electrophysiology : PACE\| PubMed ID: 18811803	2008
Interplay between impaired calcium regulation and insulin signaling abnormalities in diabetic cardiomyopathy. Nature clinical practice. Cardiovascular medicine\| PubMed ID: 18813212	2008
PICOT is a critical regulator of cardiac hypertrophy and cardiomyocyte contractility. Journal of molecular and cellular cardiology\| PubMed ID: 18929570	2008
Rescue of Ca2+ overload-induced left ventricular dysfunction by targeted ablation of phospholamban. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 19074672	2009
Mechanical work and energetic analysis of eccentric cardiac remodeling in a volume overload heart failure in rats. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 19201995	2009
Long-term cardiac-targeted RNA interference for the treatment of heart failure restores cardiac function and reduces pathological hypertrophy. Circulation\| PubMed ID: 19237664	2009
The transcription factor Eya2 prevents pressure overload-induced adverse cardiac remodeling. Journal of molecular and cellular cardiology\| PubMed ID: 19272299	2009
Inducible expression of active protein phosphatase-1 inhibitor-1 enhances basal cardiac function and protects against ischemia/reperfusion injury. Circulation research\| PubMed ID: 19299645	2009
Calcium upregulation by percutaneous administration of gene therapy in cardiac disease (CUPID Trial), a first-in-human phase 1/2 clinical trial. Journal of cardiac failure\| PubMed ID: 19327618	2009
Cardionomics: a new integrative approach for screening cardiotoxicity of drug candidates. Expert opinion on drug metabolism & toxicology\| PubMed ID: 19442031	2009
Role of protein phosphatase-1 inhibitor-1 in cardiac physiology and pathophysiology. Journal of molecular and cellular cardiology\| PubMed ID: 19481088	2009
Gene remodeling in type 2 diabetic cardiomyopathy and its phenotypic rescue with SERCA2a. PloS one\| PubMed ID: 19649297	2009
In vivo myocardial distribution of multipotent progenitor cells following intracoronary delivery in a swine model of myocardial infarction. European heart journal\| PubMed ID: 19687154	2009
Treatment of heart failure by calcium cycling gene therapy. Future cardiology\| PubMed ID: 19804232	2007
Mechanoelectrical remodeling and arrhythmias during progression of hypertrophy. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 19825979	2010
Targeted SERCA2a gene expression identifies molecular mechanism and therapeutic target for arrhythmogenic cardiac alternans. Circulation. Arrhythmia and electrophysiology\| PubMed ID: 19948504	2009
Sarcoplasmic reticulum Ca(2+) ATPase as a therapeutic target for heart failure. Expert opinion on biological therapy\| PubMed ID: 20078230	2010
Ca2+ cycling and new therapeutic approaches for heart failure. Circulation\| PubMed ID: 20124124	2010
Effects of CXCR4 gene transfer on cardiac function after ischemia-reperfusion injury. The American journal of pathology\| PubMed ID: 20133817	2010
The opposing effects of CCN2 and CCN5 on the development of cardiac hypertrophy and fibrosis. Journal of molecular and cellular cardiology\| PubMed ID: 20430035	2010
SERCA2a gene transfer enhances eNOS expression and activity in endothelial cells. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 20461063	2010
Expression of active protein phosphatase 1 inhibitor-1 attenuates chronic beta-agonist-induced cardiac apoptosis. Basic research in cardiology\| PubMed ID: 20512582	2010
Advances in gene-based therapy for heart failure. Journal of cardiovascular translational research\| PubMed ID: 20559907	2008
Gene delivery of sarcoplasmic reticulum calcium ATPase inhibits ventricular remodeling in ischemic mitral regurgitation. Circulation. Heart failure\| PubMed ID: 20634484	2010
Amniotic fluid cells are more efficiently reprogrammed to pluripotency than adult cells. Cellular reprogramming\| PubMed ID: 20677926	2010
Î²2-Adrenergic receptor signaling in the cardiac myocyte is modulated by interactions with CXCR4. Journal of cardiovascular pharmacology\| PubMed ID: 20729750	2010
Neonatal gene transfer of Serca2a delays onset of hypertrophic remodeling and improves function in familial hypertrophic cardiomyopathy. Journal of molecular and cellular cardiology\| PubMed ID: 20854827	2010
Regression of cardiac hypertrophy by cyclic guanosine monophosphate-dependent protein kinase signaling are myocytes active sources or mere beneficiaries? Journal of the American College of Cardiology\| PubMed ID: 20970281	2010
Multimodality imaging of chronic ischemia. Cardiology research and practice\| PubMed ID: 20981290	2010
Gene therapy for heart failure. Archives of cardiovascular diseases\| PubMed ID: 21074127	2010
Cardiac gene therapy. Seminars in thoracic and cardiovascular surgery\| PubMed ID: 21092890	2010
Cardiac gene therapy with SERCA2a: from bench to bedside. Journal of molecular and cellular cardiology\| PubMed ID: 21093451	2011
Adeno-associated virus serotype 8 ApoA-I gene transfer reduces progression of atherosclerosis in ApoE-KO mice: comparison of intramuscular and intravenous administration. Journal of cardiovascular pharmacology\| PubMed ID: 21164355	2011
Refilling Intracellular Calcium Stores. Drug discovery today. Disease mechanisms\| PubMed ID: 21170146	2010
Method of gene delivery in large animal models of cardiovascular diseases. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 21194040	2011
SERCA2a controls the mode of agonist-induced intracellular Ca2+ signal, transcription factor NFAT and proliferation in human vascular smooth muscle cells. Journal of molecular and cellular cardiology\| PubMed ID: 21195084	2011
Mitigation of muscular dystrophy in mice by SERCA overexpression in skeletal muscle. The Journal of clinical investigation\| PubMed ID: 21285509	2011
Rescuing the failing heart by targeted gene transfer. Journal of the American College of Cardiology\| PubMed ID: 21371634	2011
SERCA2a gene transfer decreases sarcoplasmic reticulum calcium leak and reduces ventricular arrhythmias in a model of chronic heart failure. Circulation. Arrhythmia and electrophysiology\| PubMed ID: 21406682	2011
Cyclosporine attenuates cardiomyocyte hypertrophy induced by RAF1 mutants in Noonan and LEOPARD syndromes. Journal of molecular and cellular cardiology\| PubMed ID: 21440552	2011
Resistin promotes cardiac hypertrophy via the AMP-activated protein kinase/mammalian target of rapamycin (AMPK/mTOR) and c-Jun N-terminal kinase/insulin receptor substrate 1 (JNK/IRS1) pathw... The Journal of biological chemistry\| PubMed ID: 21478152	2011
A small molecule binding to the coactivator CREB-binding protein blocks apoptosis in cardiomyocytes. Chemistry & biology\| PubMed ID: 21513889	2011
Assessment of cardiovascular fibrosis using novel fluorescent probes. PloS one\| PubMed ID: 21533060	2011
Long-term in vivo resistin overexpression induces myocardial dysfunction and remodeling in rats. Journal of molecular and cellular cardiology\| PubMed ID: 21549710	2011
American journal of physiology. Heart and circulatory physiology\| PubMed ID: 21551276	2011
Targeted gene therapy for the treatment of heart failure. The Canadian journal of cardiology\| PubMed ID: 21601767	2011
A new model of congestive heart failure in rats. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 21685270	2011
Calcium Upregulation by Percutaneous Administration of Gene Therapy in Cardiac Disease (CUPID): a phase 2 trial of intracoronary gene therapy of sarcoplasmic reticulum Ca2+-ATPase in patient... Circulation\| PubMed ID: 21709064	2011
AKT signalling in the failing heart. European journal of heart failure\| PubMed ID: 21724622	2011
Aortic implantation of mesenchymal stem cells after aneurysm injury in a porcine model. The Journal of surgical research\| PubMed ID: 21764076	2011
Critical role for stromal interaction molecule 1 in cardiac hypertrophy. Circulation\| PubMed ID: 21810664	2011
SUMO1-dependent modulation of SERCA2a in heart failure. Nature\| PubMed ID: 21900893	2011
Neutralizing antibodies against AAV serotypes 1, 2, 6, and 9 in sera of commonly used animal models. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 21915102	2012
Gene delivery methods in cardiac gene therapy. The journal of gene medicine\| PubMed ID: 21954037	2011
Inhibition of PKCÎ±/Î² with ruboxistaurin antagonizes heart failure in pigs after myocardial infarction injury. Circulation research\| PubMed ID: 21998327	2011
Shrink-film configurable multiscale wrinkles for functional alignment of human embryonic stem cells and their cardiac derivatives. Advanced materials (Deerfield Beach, Fla.)\| PubMed ID: 22065428	2011
Distinct roles of microRNA-1 and -499 in ventricular specification and functional maturation of human embryonic stem cell-derived cardiomyocytes. PloS one\| PubMed ID: 22110643	2011
Cardiac gene therapy: from concept to reality. Current heart failure reports\| PubMed ID: 22143928	2012
Transcription coactivator Eya2 is a critical regulator of physiological hypertrophy. Journal of molecular and cellular cardiology\| PubMed ID: 22197309	2011
Concomitant Intravenous Nitroglycerin With Intracoronary Delivery of AAV1.SERCA2a Enhances Gene Transfer in Porcine Hearts. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 22215018	2012
Temporal changes of strain parameters in the progress of chronic ischemia: with comparison to transmural infarction. The international journal of cardiovascular imaging\| PubMed ID: 22231467	2012
Tracking cell therapy: bioluminescence lighting the way. JACC. Cardiovascular imaging\| PubMed ID: 22239893	2012
Assessing left ventricular systolic dysfunction after myocardial infarction: are the ejection fraction and the dP/dt maximum complementary or redundant? American journal of physiology. Heart and circulatory physiology\| PubMed ID: 22307667	2012