Changyu Zheng

Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, NIH, DHHS

Affiliated withNational Institute of Dental and Craniofacial Research, NIH, DHHS

Research Area

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 17	2011
Publication title Cited by 5	2016

Other Publications

Article	Year
Long-term expression after infection by the hybrid vector AdLTR-luc is from integrated transgene. Biochemical and biophysical research communications\| PubMed ID: 11829458	2002
Gene transfer to salivary glands. International review of cytology\| PubMed ID: 11837896	2002
Integration efficiency of a hybrid adenoretroviral vector. Biochemical and biophysical research communications\| PubMed ID: 12480529	2003
Distribution and toxicity resulting from adenoviral vector administration to a single salivary gland in adult rats. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology\| PubMed ID: 12846788	2003
Inclusion of Moloney murine leukemia virus elements upstream of the transgene cassette in an E1-deleted adenovirus leads to an unusual genomic integration in epithelial cells. Virology\| PubMed ID: 12954213	2003
Advances in vector-mediated gene transfer. Immunology letters\| PubMed ID: 14687716	2003
Reengineered salivary glands are stable endogenous bioreactors for systemic gene therapeutics. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 14978265	2004
Combined alpha tumor necrosis factor gene therapy and engineered dendritic cell vaccine in combating well-established tumors. The journal of gene medicine\| PubMed ID: 15293344	2004
Intratumoral administration of immature dendritic cells following the adenovirus vector encoding CD40 ligand elicits significant regression of established myeloma. Cancer gene therapy\| PubMed ID: 15565183	2005
Salivary glands as a potential gene transfer target for gene therapeutics of some monogenetic endocrine disorders. The Journal of endocrinology\| PubMed ID: 15930162	2005
Significant tumor regression induced by microencapsulation of recombinant tumor cells secreting fusion protein. Cancer biotherapy & radiopharmaceuticals\| PubMed ID: 15989471	2005
Evaluation of viral and mammalian promoters for use in gene delivery to salivary glands. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 16099414	2005
Vaccine of engineered tumor cells secreting stromal cell-derived factor-1 induces T-cell dependent antitumor responses. Cancer biotherapy & radiopharmaceuticals\| PubMed ID: 16114988	2005
Transfer of the AQP1 cDNA for the correction of radiation-induced salivary hypofunction. Biochimica et biophysica acta\| PubMed ID: 16368071	2006
Toxicity and biodistribution of a first-generation recombinant adenoviral vector, encoding aquaporin-1, after retroductal delivery to a single rat submandibular gland. Human gene therapy\| PubMed ID: 17069536	2006
Adeno-associated virus serotype 2-mediated gene transfer to the parotid glands of nonhuman primates. Human gene therapy\| PubMed ID: 17328682	2007
Female mice are more susceptible to developing inflammatory disorders due to impaired transforming growth factor beta signaling in salivary glands. Arthritis and rheumatism\| PubMed ID: 17530708	2007
Sorting of transgenic secretory proteins in miniature pig parotid glands following adenoviral-mediated gene transfer. The journal of gene medicine\| PubMed ID: 17654745	2007
Adeno-associated virus type 12 (AAV12): a novel AAV serotype with sialic acid- and heparan sulfate proteoglycan-independent transduction activity. Journal of virology\| PubMed ID: 18045941	2008
Sorting behavior of a transgenic erythropoietin-growth hormone fusion protein in murine salivary glands. Human gene therapy\| PubMed ID: 18303958	2008
Extended transgene expression from a nonintegrating adenoviral vector containing retroviral elements. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 18388914	2008
Evaluation of promoters for use in tissue-specific gene delivery. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 18470647	2008
Sorting of growth hormone-erythropoietin fusion proteins in rat salivary glands. Biochemical and biophysical research communications\| PubMed ID: 18544341	2008
Sorting of transgenic secretory proteins in rhesus macaque parotid glands after adenovirus-mediated gene transfer. Human gene therapy\| PubMed ID: 18764738	2008
Aquaporin-1 gene transfer to correct radiation-induced salivary hypofunction. Handbook of experimental pharmacology\| PubMed ID: 19096789	2009
Long-term transduction of miniature pig parotid glands using serotype 2 adeno-associated viral vectors. The journal of gene medicine\| PubMed ID: 19326368	2009
In vivo secretion of the mouse immunoglobulin G Fc fragment from rat submandibular glands. The journal of gene medicine\| PubMed ID: 19424985	2009
Prevention of radiation-induced oral mucositis after adenoviral vector-mediated transfer of the keratinocyte growth factor cDNA to mouse submandibular glands. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 19584147	2009
Adenoviral mediated transduction of adenoid cystic carcinoma by human TRAIL gene driven with hTERT tumor specific promoter induces apoptosis. Cancer biology & therapy\| PubMed ID: 19587531	2009
Development of a gene transfer-based treatment for radiation-induced salivary hypofunction. Oral oncology\| PubMed ID: 19892587	2010
Transient detection of E1-containing adenovirus in saliva after the delivery of a first-generation adenoviral vector to human parotid gland. The journal of gene medicine\| PubMed ID: 19941317	2010
Production and sorting of transgenic, modified human parathyroid hormone in vivo in rat salivary glands. Biochemical and biophysical research communications\| PubMed ID: 19944067	2010
Conditional overexpression of TGF-beta1 disrupts mouse salivary gland development and function. Laboratory investigation; a journal of technical methods and pathology\| PubMed ID: 20142803	2010
Salivary epithelial cells: an unassuming target site for gene therapeutics. The international journal of biochemistry & cell biology\| PubMed ID: 20219693	2010
Systemic delivery of bioactive glucagon-like peptide 1 after adenoviral-mediated gene transfer in the murine salivary gland. Endocrinology\| PubMed ID: 20610567	2010
Gene therapy of salivary diseases. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 20717774	2010
Effect of irradiation on microvascular endothelial cells of parotid glands in the miniature pig. International journal of radiation oncology, biology, physics\| PubMed ID: 20832188	2010
Prevention of radiation-induced salivary hypofunction following hKGF gene delivery to murine submandibular glands. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 21367751	2011
Assessment of the safety and biodistribution of a regulated AAV2 gene transfer vector after delivery to murine submandibular glands. Toxicological sciences : an official journal of the Society of Toxicology\| PubMed ID: 21625005	2011
Pharmacological Protection from Radiation Â± Cisplatin-induced Oral Mucositis. International journal of radiation oncology, biology, physics\| PubMed ID: 22197226	2011
Antitumor effect of human TRAIL on adenoid cystic carcinoma using magnetic nanoparticle-mediated gene expression. Nanomedicine : nanotechnology, biology, and medicine\| PubMed ID: 22633896	2013
Sialin (SLC17A5) functions as a nitrate transporter in the plasma membrane. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22778404	2012
Sustained exendin-4 secretion through gene therapy targeting salivary glands in two different rodent models of obesity/type 2 diabetes. PloS one\| PubMed ID: 22808093	2012
A novel hybrid adenoretroviral vector with more extensive E3 deletion extends transgene expression in submandibular glands. Human gene therapy methods\| PubMed ID: 22817829	2012
Early responses to adenoviral-mediated transfer of the aquaporin-1 cDNA for radiation-induced salivary hypofunction. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23129637	2012
Impairment of TRPC1-STIM1 channel assembly and AQP5 translocation compromise agonist-stimulated fluid secretion in mice lacking caveolin1. Journal of cell science\| PubMed ID: 23203809	2013
Recovery of radiation-induced dry eye and corneal damage by pretreatment with adenoviral vector-mediated transfer of erythropoietin to the salivary glands in mice. Human gene therapy\| PubMed ID: 23402345	2013
Loss of TRPM2 function protects against irradiation-induced salivary gland dysfunction. Nature communications\| PubMed ID: 23443543	2013
Irbit mediates synergy between ca(2+) and cAMP signaling pathways during epithelial transport in mice. Gastroenterology\| PubMed ID: 23542070	2013
Expression and secretion of human proinsulin-B10 from mouse salivary glands: implications for the treatment of type I diabetes mellitus. PloS one\| PubMed ID: 23554999	2013
miR-150 promotes renal fibrosis in lupus nephritis by downregulating SOCS1. Journal of the American Society of Nephrology : JASN\| PubMed ID: 23723424	2013
Using poly(lactic-co-glycolic acid) microspheres to encapsulate plasmid of bone morphogenetic protein 2/polyethylenimine nanoparticles to promote bone formation in vitro and in vivo. International journal of nanomedicine\| PubMed ID: 23990717	2013
Enhancement of osteoinduction by continual simvastatin release from poly(lactic-co-glycolic acid)-hydroxyapatite-simvastatin nano-fibrous scaffold. Journal of biomedical nanotechnology\| PubMed ID: 24059091	2013
Antitumor effect of TRAIL on oral squamous cell carcinoma using magnetic nanoparticle-mediated gene expression. Cell biochemistry and biophysics\| PubMed ID: 24563116	2014
Toxicity and biodistribution of the serotype 2 recombinant adeno-associated viral vector, encoding Aquaporin-1, after retroductal delivery to a single mouse parotid gland. PloS one\| PubMed ID: 24667436	2014
All human EF1α promoters are not equal: markedly affect gene expression in constructs from different sources. International journal of medical sciences\| PubMed ID: 24688302	2014
Efficiently engineered cell sheet using a complex of polyethylenimine-alginate nanocomposites plus bone morphogenetic protein 2 gene to promote new bone formation. International journal of nanomedicine\| PubMed ID: 24855355	2014
Integration of the hybrid adenoretroviral vector AdLTR-luc involves both MoMLV elements flanking the transgene. International journal of medical sciences\| PubMed ID: 24936143	2014
Assessment of transfection of AdCMV-EGFP to rat submandibular gland cells. Cell biochemistry and biophysics\| PubMed ID: 25108736	2015
STIM2 enhances receptor-stimulated Ca²⁺ signaling by promoting recruitment of STIM1 to the endoplasmic reticulum-plasma membrane junctions. Science signaling\| PubMed ID: 25587190	2015
Advances in salivary gland gene therapy - oral and systemic implications. Expert opinion on biological therapy\| PubMed ID: 26149284	2015
Inhibition of autophagy by 3-MA enhances IL-24-induced apoptosis in human oral squamous cell carcinoma cells. Journal of experimental & clinical cancer research : CR\| PubMed ID: 26361755	2015
Essential role of carbonic anhydrase XII in secretory gland fluid and HCO3 (-) secretion revealed by disease causing human mutation. The Journal of physiology\| PubMed ID: 26486891	2015
Effects of human vascular endothelial growth factor on reparative dentin formation. Molecular medicine reports\| PubMed ID: 26647730	2016