Hiroshi Harada

Department of Radiation Oncology, Kyoto University Graduate School of Medicine

Affiliated withKyoto University Graduate School of Medicine

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 16	2011

Other Publications

Article	Year
Antitumor effect of TAT-oxygen-dependent degradation-caspase-3 fusion protein specifically stabilized and activated in hypoxic tumor cells. Cancer research\| PubMed ID: 11929818	2002
Alveolar adenoma of the lung: computed tomography and magnetic resonance imaging findings. Journal of thoracic imaging\| PubMed ID: 11956369	2002
Novel N-[1-(1-substituted 4-piperidinylmethyl)-4-piperidinyl]benzamides as potent colonic prokinetic agents. Bioorganic & medicinal chemistry letters\| PubMed ID: 11959005	2002
Expression of matrix metalloproteinase in the fluids of renal cystic lesions. The Journal of urology\| PubMed ID: 12050483	2002
Difference in the metabolism of vitamin K between liver and bone in vitamin K-deficient rats. The British journal of nutrition\| PubMed ID: 12064340	2002
Synthesis and structure-activity relationships of 4-amino-5-chloro-N-(1,4-dialkylhexahydro-1,4-diazepin-6-yl)-2-methoxybenzamide derivatives, novel and potent serotonin 5-HT3 and dopamine D2... Chemical & pharmaceutical bulletin\| PubMed ID: 12130853	2002
Elastic constant measurement of Ni-base superalloy with the RUS and mode selective EMAR methods. Ultrasonics\| PubMed ID: 12159934	2002
Physiological mechanisms of regulating alloimmunity: cytokines, CTLA-4, CD25+ cells, and the alloreactive T cell clone size. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 12244168	2002
New insights into the interactions between T-cell costimulatory blockade and conventional immunosuppressive drugs. Annals of surgery\| PubMed ID: 12409674	2002
Characterization of the epithelial components in pleomorphic adenoma of the salivary gland. Acta cytologica\| PubMed ID: 12462088	2002
Traumatic middle meningeal artery pseudoaneurysm and subsequent fistula formation with the cavernous sinus: case report. Surgical neurology\| PubMed ID: 12504299	2002
Modified Dumon stent for the treatment of a bronchopleural fistula after pneumonectomy. The Annals of thoracic surgery\| PubMed ID: 12537239	2003
Synthesis and structure-affinity relationships of novel N-(1-ethyl-4-methylhexahydro-1,4-diazepin-6-yl)pyridine-3-carboxamides with potent serotonin 5-HT3 and dopamine D2 receptor antagonist... Journal of medicinal chemistry\| PubMed ID: 12593651	2003
Enterolosaponins A and B, novel triterpene bisdesmosides from Enterolobium contortisiliquum, and evaluation for their macrophage-oriented cytotoxic activity. Bioorganic & medicinal chemistry letters\| PubMed ID: 12639544	2003
Appendicitis caused by caecal carcinoma: report of a case. The Kurume medical journal\| PubMed ID: 12652973	2002
[Autoimmune hepatitis, Basedow's disease and myasthenia gravis]. Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine\| PubMed ID: 12655697	2002
Novel and potent human and rat beta3-adrenergic receptor agonists containing substituted 3-indolylalkylamines. Bioorganic & medicinal chemistry letters\| PubMed ID: 12657269	2003
Hyperacute onset of haemolytic-uraemic syndrome associated with hyperacute rejection in the recipient of an ABO-incompatible kidney. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association\| PubMed ID: 12686680	2003
Cytogenetics, FISH and RT-PCR analysis of acute promyelocytic leukemia: structure of the fusion point in a case lacking classic t(15;17) translocation. Leukemia & lymphoma\| PubMed ID: 12691149	2003
CD45RB-targeting strategies for promoting long-term allograft survival and preventingchronic allograft vasculopathy. Transplantation\| PubMed ID: 12717193	2003
Detection of C-Si covalent bond in CH3 adsorbate formed by chemical reaction of CH3MgBr and H:Si(111). Journal of the American Chemical Society\| PubMed ID: 12823027	2003
The role of the ICOS-B7h T cell costimulatory pathway in transplantation immunity. The Journal of clinical investigation\| PubMed ID: 12865411	2003
Triterpenes and triterpene saponins from the stems of Akebia trifoliata. Chemical & pharmaceutical bulletin\| PubMed ID: 12913236	2003
The biological activity and tissue distribution of 2',3'-dihydrophylloquinone in rats. Biochimica et biophysica acta\| PubMed ID: 12928110	2003
Tumor hypoxia: a target for selective cancer therapy. Cancer science\| PubMed ID: 14662015	2003
Cytomorphologic features of a polymorphous low grade adenocarcinoma of the palate. A report of 2 cases with immunocytochemistry. Acta cytologica\| PubMed ID: 14674096	2003
Squamous metaplasia mimicking papillary carcinoma in the upper urinary tract. [Hokkaido igaku zasshi] The Hokkaido journal of medical science\| PubMed ID: 14978970	2004
Cytopathological features of an epithelial-myoepithelial carcinoma with predominant clear myoepithelial cells in the parotid gland. Diagnostic cytopathology\| PubMed ID: 15048967	2004
Extracellular material in adenoid cystic carcinoma of the salivary glands: a comparative cytological study with other salivary myoepithelial tumors. Diagnostic cytopathology\| PubMed ID: 15236258	2004
Distribution of lichen flora on South Korea. Journal of microbiology (Seoul, Korea)\| PubMed ID: 15357314	2004
Biotransformation of soy isoflavone-glycosides in laying hens: intestinal absorption and preferential accumulation into egg yolk of equol, a more estrogenic metabolite of daidzein. Biochimica et biophysica acta\| PubMed ID: 15374616	2004
Video-assisted thoracic surgery lobectomy for extralobar pulmonary sequestration in a child: report of a case. Surgery today\| PubMed ID: 15526132	2004
Tryptamine-based human beta3-adrenergic receptor agonists. Part 1: SAR studies of the 7-position of the indole ring. Bioorganic & medicinal chemistry letters\| PubMed ID: 15546707	2004
Tryptamine-based human beta3-adrenergic receptor agonists. Part 2: SAR of the methylene derivatives. Bioorganic & medicinal chemistry letters\| PubMed ID: 15546708	2004
Discovery of 1,7-cyclized indoles as a new class of potent and highly selective human beta3-adrenergic receptor agonists with high cell permeability. Bioorganic & medicinal chemistry\| PubMed ID: 15653351	2005
CD70 signaling is critical for CD28-independent CD8+ T cell-mediated alloimmune responses in vivo. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 15661893	2005
Discovery of a novel and potent human and rat beta3-adrenergic receptor agonist, [3-[(2R)-[[(2R)-(3-chlorophenyl)-2-hydroxyethyl]amino]propyl]-1H-indol-7-yloxy]acetic acid. Chemical & pharmaceutical bulletin\| PubMed ID: 15684518	2005
[Relationship between dose of mycophenolate mofetil and the occurrence of cytomegalovirus infection and diarrhea in renal transplant recipients]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan\| PubMed ID: 15684572	2005
Tryptamine-based human beta3-adrenergic receptor agonists. Part 3: improved oral bioavailability via modification of the sulfonamide moiety. Bioorganic & medicinal chemistry letters\| PubMed ID: 15686912	2005
Is eradication therapy useful as the first line of treatment in Helicobacter pylori-positive idiopathic thrombocytopenic purpura? Analysis of 207 eradicated chronic ITP cases in Japan. International journal of hematology\| PubMed ID: 15765787	2005
Real-time imaging of hypoxia-inducible factor-1 activity in tumor xenografts. Journal of radiation research\| PubMed ID: 15802864	2005
Aminopeptidase N/CD13 targeting fluorescent probes: synthesis and application to tumor cell imaging. Peptides\| PubMed ID: 15885853	2005
A tumor-specific gene therapy strategy targeting dysregulation of the VHL/HIF pathway in renal cell carcinomas. Cancer science\| PubMed ID: 15904470	2005
Quadruple immunosuppression with basiliximab, tacrolimus, mycophenolate mofetil and prednisone is safe and effective for renal transplantation. Clinical transplantation\| PubMed ID: 15955170	2005
p63 Expression of clear myoepithelial cells in epithelial-myoepithelial carcinoma of the salivary gland: a useful marker for naked myoepithelial cells in cytology. Cancer\| PubMed ID: 15959915	2005
Requirements for induction and maintenance of peripheral tolerance in stringent allograft models. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16150717	2005
Optical imaging of tumor hypoxia and evaluation of efficacy of a hypoxia-targeting drug in living animals. Molecular imaging\| PubMed ID: 16194450	2005
Sarpogrelate hydrochloride, an antagonist of 5-hydroxytryptamine receptor, improves skin flap survival and suppresses thrombus formation in injured microvessels of rabbits. Journal of reconstructive microsurgery\| PubMed ID: 16425124	2006
Recent developments in the design of orally bioavailable beta3-adrenergic receptor agonists. Current medicinal chemistry\| PubMed ID: 16457637	2006
Antitumor protein therapy; application of the protein transduction domain to the development of a protein drug for cancer treatment. Breast cancer (Tokyo, Japan)\| PubMed ID: 16518058	2006
[Pharmacokinetics and disposition of silodosin (KMD-3213)]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan\| PubMed ID: 16518089	2006
[Tumor-specific gene therapy strategy for renal cell carcinomas]. Nihon rinsho. Japanese journal of clinical medicine\| PubMed ID: 16523975	2006
Epididymo-orchitis caused by intravesically instillated bacillus Calmette-GuÃ©rin: genetically proven using a multiplex polymerase chain reaction method. International journal of urology : official journal of the Japanese Urological Association\| PubMed ID: 16563148	2006
Late corticosteroid withdrawal can be safely performed for kidney recipients with stable graft function under pathological confirmation. Clinical transplantation\| PubMed ID: 16848872	2006
Positive pre-transplant flow-panel reactive antibody detected after accelerated acute rejection with negative pre-transplant flow crossmatch. Clinical transplantation\| PubMed ID: 16848873	2006
Giant cell-rich osteosarcoma of the distal femur: radiographic and magnetic resonance imaging findings. Radiation medicine\| PubMed ID: 16875313	2006
Retroperitoneal lipomatous angiomyolipoma associated with amyloid deposition masquerading as well-differentiated liposarcoma. Pathology international\| PubMed ID: 16984623	2006
Mechanism of hypoxia-specific cytotoxicity of procaspase-3 fused with a VHL-mediated protein destruction motif of HIF-1alpha containing Pro564. FEBS letters\| PubMed ID: 17010341	2006
Olfactory neuroepithelioma: an immunohistochemical and ultrastructural study. Neuropathology : official journal of the Japanese Society of Neuropathology\| PubMed ID: 17080716	2006
Salivary duct carcinoma in the sinonasal tract. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery\| PubMed ID: 17203308	2007
Fine-needle aspiration cytology of basal cell adenoma of the parotid gland: characteristic cytological features and diagnostic pitfalls. Diagnostic cytopathology\| PubMed ID: 17230571	2007
Laparoscopy-assisted distal gastrectomy with 3-cm laparotomy, left hepatic lobe compression technique, and selection of automatic anastomosis device. Hepato-gastroenterology\| PubMed ID: 17419220	2007
[Clinical evaluation of biapenem for febrile neutropenia in patients with hematological disorders]. The Japanese journal of antibiotics\| PubMed ID: 17612259	2007
The combination of hypoxia-response enhancers and an oxygen-dependent proteolytic motif enables real-time imaging of absolute HIF-1 activity in tumor xenografts. Biochemical and biophysical research communications\| PubMed ID: 17624305	2007
Argon plasma coagulation for a bleeding gastrointestinal stromal tumor. Digestion\| PubMed ID: 17684366	2007
[Clinical analysis of HLA-DR-negative non-M3 AML]. [RinshÅ ketsueki] The Japanese journal of clinical hematology\| PubMed ID: 17695303	2007
Bone disorder and vitamin D after gastric cancer surgery. Hepato-gastroenterology\| PubMed ID: 17708309	2007
13C-urea breath test in patients having undergone total gastrectomy. Hepato-gastroenterology\| PubMed ID: 17708310	2007
The validity of sentinel lymph node biopsy using dye technique alone in patients with gastric cancer. Hepato-gastroenterology\| PubMed ID: 18019740	2007
Emission under hypoxia: one-electron reduction and fluorescence characteristics of an indolequinone-coumarin conjugate. Chembiochem : a European journal of chemical biology\| PubMed ID: 18224643	2008
Field testing of a remote controlled robotic tele-echo system in an ambulance using broadband mobile communication technology. Journal of medical systems\| PubMed ID: 18444361	2008
Salivary duct carcinoma cytologically diagnosed distinctly from salivary gland carcinomas with squamous differentiation. Diagnostic cytopathology\| PubMed ID: 18528886	2008
Diameter of tumor blood vessels is a good parameter to estimate HIF-1-active regions in solid tumors. Biochemical and biophysical research communications\| PubMed ID: 18586004	2008
TS-1 enhances the effect of radiotherapy by suppressing radiation-induced hypoxia-inducible factor-1 activation and inducing endothelial cell apoptosis. Cancer science\| PubMed ID: 18823375	2008
The Akt/mTOR pathway assures the synthesis of HIF-1alpha protein in a glucose- and reoxygenation-dependent manner in irradiated tumors. The Journal of biological chemistry\| PubMed ID: 19098000	2009
A liquid chromatography/tandem mass spectrometry method for detecting UGT-mediated bioactivation of drugs as their N-acetylcysteine adducts in human liver microsomes. Rapid communications in mass spectrometry : RCM\| PubMed ID: 19177506	2009
Ring-opening metathesis polymerization-based synthesis of ICG-containing amphiphilic triblock copolymers for in vivo tumor imaging. Bioconjugate chemistry\| PubMed ID: 19193062	2009
Radiolytic activation of a cytarabine prodrug possessing a 2-oxoalkyl group: one-electron reduction and cytotoxicity characteristics. Organic & biomolecular chemistry\| PubMed ID: 19194578	2009
Molecular cloning of t(2;7)(p24.3;p14.2), a novel chromosomal translocation in myelodysplastic syndrome-derived acute myeloid leukemia. Journal of human genetics\| PubMed ID: 19407829	2009
The HIF-1-active microenvironment: an environmental target for cancer therapy. Advanced drug delivery reviews\| PubMed ID: 19409433	2009
Clinicopathologic evaluation of short-term outcome after early corticosteroid discontinuation in kidney transplantation. Clinical transplantation\| PubMed ID: 19594589	2009
Successful rescue of late-onset acute T-cell mediated rejection with anti-CD25 antibody: a case report. Clinical transplantation\| PubMed ID: 19594593	2009
The intravenous anesthetics barbiturates inhibit hypoxia-inducible factor 1 activation. European journal of pharmacology\| PubMed ID: 19595685	2009
Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms. Nature\| PubMed ID: 19620960	2009
Usefulness of HIF-1 imaging for determining optimal timing of combining bevacizumab and radiotherapy. International journal of radiation oncology, biology, physics\| PubMed ID: 19735869	2009
Monitoring of biological one-electron reduction by (19)F NMR using hypoxia selective activation of an (19)F-labeled indolequinone derivative. Journal of the American Chemical Society\| PubMed ID: 19842623	2009
Ring-opening metathesis polymerization-based synthesis of polymeric nanoparticles for enhanced tumor imaging in vivo: Synergistic effect of folate-receptor targeting and PEGylation. Biomaterials\| PubMed ID: 19853909	2010
Cytological features of cystadenocarcinoma in cyst fluid of the parotid gland: Diagnostic pitfalls and literature review. Diagnostic cytopathology\| PubMed ID: 19927358	2010
A novel strategy to tag matrix metalloproteinases-positive cells for in vivo imaging of invasive and metastatic activity of tumor cells. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 20096316	2010
(99m)Tc-DTPA dynamic SPECT and CT volumetry for measuring split renal function in live kidney donors. Annals of nuclear medicine\| PubMed ID: 20213340	2010
Clinical evaluation of tocilizumab for patients with active rheumatoid arthritis refractory to anti-TNF biologics: tocilizumab in combination with methotrexate. Modern rheumatology / the Japan Rheumatism Association\| PubMed ID: 20480201	2010
A case of pregnancy-induced thrombotic thrombocytopenic purpura with a kidney allograft recipient. Clinical transplantation\| PubMed ID: 20590698	2010
Synthesis and biological evaluation of indolyl chalcones as antitumor agents. Bioorganic & medicinal chemistry letters\| PubMed ID: 20627724	2010
AHR, a novel acute hypoxia-response sequence, drives reporter gene expression under hypoxia in vitro and in vivo. Cell biology international\| PubMed ID: 20795945	2011
Direct targeting of fibroblast growth factor-inducible 14 protein protects against renal ischemia reperfusion injury. Kidney international\| PubMed ID: 20927042	2011
Polymorphisms in growth hormone gene and their associations with calf weight in Japanese Black cattle. Animal science journal = Nihon chikusan GakkaihÅ\| PubMed ID: 21108680	2010
Nuclear Î²-catenin expression in basal cell adenomas of salivary gland. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology\| PubMed ID: 21323741	2011
Effective encapsulation of a new cationic gadolinium chelate into apoferritin and its evaluation as an MRI contrast agent. Nanomedicine : nanotechnology, biology, and medicine\| PubMed ID: 21333752	2011
Angiogenic and vasoprotective effects of adrenomedullin on prevention of cognitive decline after chronic cerebral hypoperfusion in mice. Stroke; a journal of cerebral circulation\| PubMed ID: 21393586	2011
No immunotoxic effect on T cells with di (2-ethylhexyl) phthalate in male C57BL/6 mice. Environmental health and preventive medicine\| PubMed ID: 21432090	2003
Images in clinical medicine. Calcification of the aorta and common iliac arteries. The New England journal of medicine\| PubMed ID: 21488767	2011
Angiogenic roles of adrenomedullin through vascular endothelial growth factor induction. Neuroreport\| PubMed ID: 21558971	2011
Histiocytic sarcoma of the parotid gland region. Pathology international\| PubMed ID: 21615614	2011
[Remission induced by dose-reduction of immunosuppressants alone in a patient with post-transplant lymphoproliferative disorder of central nervous system origin]. [RinshÅ ketsueki] The Japanese journal of clinical hematology\| PubMed ID: 21646772	2011
High-contrast fluorescence imaging of tumors in vivo using nanoparticles of amphiphilic brush-like copolymers produced by ROMP. Angewandte Chemie (International ed. in English)\| PubMed ID: 21656616	2011
Fentanyl activates hypoxia-inducible factor 1 in neuronal SH-SY5Y cells and mice under non-hypoxic conditions in a Î¼-opioid receptor-dependent manner. European journal of pharmacology\| PubMed ID: 21703258	2011
How can we overcome tumor hypoxia in radiation therapy? Journal of radiation research\| PubMed ID: 21952313	2011
Hydrogen sulfide inhibits hypoxia- but not anoxia-induced hypoxia-inducible factor 1 activation in a von hippel-lindau- and mitochondria-dependent manner. Antioxidants & redox signaling\| PubMed ID: 22004513	2012
Influence of side chain length on fluorescence intensity of ROMP-based polymeric nanoparticles and their tumor specificity in in-vivo tumor imaging. Small (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 22038685	2011
Successful treatment with gemtuzumab ozogamicin and donor lymphocyte infusion for acute myeloid leukemia relapsing after allogeneic stem cell transplantation. International journal of hematology\| PubMed ID: 22135078	2011
An invasive adenocarcinoma of the accessory parotid gland: a rare example developing from a low-grade cribriform cystadenocarcinoma? Diagnostic pathology\| PubMed ID: 22151879	2011
[A case of an elderly breast cancer patient achieving partial response with toremifene without efficacy of letrozole as a preoperative primary endocrine therapy]. Gan to kagaku ryoho. Cancer & chemotherapy\| PubMed ID: 22189230	2011