Martin Tolstrup

Department of Clinical Medicine, Aarhus University

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 6	2020

Other Publications

Article	Year
Short-Course Toll-Like Receptor 9 Agonist Treatment Impacts Innate Immunity and Plasma Viremia in Individuals With Human Immunodeficiency Virus Infection. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America\| PubMed ID: 28329286	2017
Full fusion competence rescue of the enfuvirtide resistant HIV-1 gp41 genotype (43D) by a prevalent polymorphism (137K). AIDS (London, England)\| PubMed ID: 17301572	2007
Entecavir therapy induces de novo HIV reverse-transcriptase M184V mutation in an antiretroviral therapy-naive patient. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America\| PubMed ID: 18419429	2008
Population-based study of diagnostic assays for Borrelia infection: comparison of purified flagella antigen assay (Ideia, Dako Cytomation) and recombinant antigen assay (Liaison, DiaSorin). BMC clinical pathology\| PubMed ID: 18423001	2008
Transmission of HIV-1 drug-resistant variants: prevalence and effect on treatment outcome. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America\| PubMed ID: 20085464	2010
Tenofovir selectively regulates production of inflammatory cytokines and shifts the IL-12/IL-10 balance in human primary cells. Journal of acquired immune deficiency syndromes (1999)\| PubMed ID: 21471820	2011
Endotoxemia is associated with altered innate and adaptive immune responses in untreated HIV-1 infected individuals. PloS one\| PubMed ID: 21731690	2011
Induction of humoral and cellular immune responses against the HIV-1 envelope protein using γ-retroviral virus-like particles. Virology journal\| PubMed ID: 21806819	2011
Evaluation of cardiovascular biomarkers in HIV-infected patients switching to abacavir or tenofovir based therapy. BMC infectious diseases\| PubMed ID: 21970555	2011
Timing of Toll-like receptor 9 agonist administration in pneumococcal vaccination impacts both humoral and cellular immune responses as well as nasopharyngeal colonization in mice. Infection and immunity\| PubMed ID: 22371375	2012
Comparison of bone and renal effects in HIV-infected adults switching to abacavir or tenofovir based therapy in a randomized trial. PloS one\| PubMed ID: 22479327	2012
Construction of a gammaretrovirus with a novel tropism and wild-type replication kinetics capable of using human APJ as entry receptor. Journal of virology\| PubMed ID: 22811542	2012
TLR9-adjuvanted pneumococcal conjugate vaccine induces antibody-independent memory responses in HIV-infected adults. Human vaccines & immunotherapeutics\| PubMed ID: 22854665	2012
The impact of B-cell perturbations on pneumococcal conjugate vaccine response in HIV-infected adults. PloS one\| PubMed ID: 22860110	2012
Antiviral and immunological effects of tenofovir microbicide in vaginal herpes simplex virus 2 infection. AIDS research and human retroviruses\| PubMed ID: 22867119	2012
Comparison of HDAC inhibitors in clinical development: effect on HIV production in latently infected cells and T-cell activation. Human vaccines & immunotherapeutics\| PubMed ID: 23370291	2013
Eliminating the latent HIV reservoir by reactivation strategies: advancing to clinical trials. Human vaccines & immunotherapeutics\| PubMed ID: 23563519	2013
Administration of a Toll-like receptor 9 agonist decreases the proviral reservoir in virologically suppressed HIV-infected patients. PloS one\| PubMed ID: 23637967	2013
Anti-inflammatory effect of a retrovirus-derived immunosuppressive peptide in mouse models. BMC immunology\| PubMed ID: 24245569	2013
Comparison of the immunogenicity and reactogenicity of Cervarix and Gardasil human papillomavirus vaccines in HIV-infected adults: a randomized, double-blind clinical trial. The Journal of infectious diseases\| PubMed ID: 24273179	2014
Editorial commentary: Reversing latency in HIV-infected patients. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America\| PubMed ID: 24336824	2014
T cells detect intracellular DNA but fail to induce type I IFN responses: implications for restriction of HIV replication. PloS one\| PubMed ID: 24404168	2014
Comparison of the immunogenicity of Cervarix® and Gardasil® human papillomavirus vaccines for oncogenic non-vaccine serotypes HPV-31, HPV-33, and HPV-45 in HIV-infected adults. Human vaccines & immunotherapeutics\| PubMed ID: 24553190	2014
Polymers fight HIV: potent (pro)drugs identified through parallel automated synthesis. Advanced healthcare materials\| PubMed ID: 24811313	2015
Highly active macromolecular prodrugs inhibit expression of the hepatitis C virus genome in the host cells. Advanced healthcare materials\| PubMed ID: 25132665	2015
Vaccination against oncogenic human papillomavirus infection in HIV-infected populations: review of current status and future perspectives. Sexual health\| PubMed ID: 25218800	2014
Disulfide reshuffling triggers the release of a thiol-free anti-HIV agent to make up fast-acting, potent macromolecular prodrugs. Chemical communications (Cambridge, England)\| PubMed ID: 25285337	2014
The histone deacetylase inhibitor panobinostat lowers biomarkers of cardiovascular risk and inflammation in HIV patients. AIDS (London, England)\| PubMed ID: 25870990	2015
Interleukin-37 Expression Is Increased in Chronic HIV-1-Infected Individuals and Is Associated with Inflammation and the Size of the Total Viral Reservoir. Molecular medicine (Cambridge, Mass.)\| PubMed ID: 25879630	2015
High level of HIV-1 drug resistance among patients with HIV-1 and HIV-1/2 dual infections in Guinea-Bissau. Virology journal\| PubMed ID: 25889017	2015
Histone deacetylase inhibitor romidepsin inhibits de novo HIV-1 infections. Antimicrobial agents and chemotherapy\| PubMed ID: 25896701	2015
Activation of latent human immunodeficiency virus by the histone deacetylase inhibitor panobinostat: a pilot study to assess effects on the central nervous system. Open forum infectious diseases\| PubMed ID: 26034779	2015
HIV Reactivation from Latency after Treatment Interruption Occurs on Average Every 5-8 Days--Implications for HIV Remission. PLoS pathogens\| PubMed ID: 26133551	2015
Innate Immune Activity Correlates with CD4 T Cell-Associated HIV-1 DNA Decline during Latency-Reversing Treatment with Panobinostat. Journal of virology\| PubMed ID: 26223643	2015
The Depsipeptide Romidepsin Reverses HIV-1 Latency In Vivo. PLoS pathogens\| PubMed ID: 26379282	2015
Panobinostat, a histone deacetylase inhibitor, for latent-virus reactivation in HIV-infected patients on suppressive antiretroviral therapy: a phase 1/2, single group, clinical trial. The lancet. HIV\| PubMed ID: 26423811	2014
HIV-1 transcriptional activity during frequent longitudinal sampling in aviremic patients on antiretroviral therapy. AIDS (London, England)\| PubMed ID: 26595541	2016
Reversal of Latency as Part of a Cure for HIV-1. Trends in microbiology\| PubMed ID: 26690612	2016
Administration of Panobinostat Is Associated with Increased IL-17A mRNA in the Intestinal Epithelium of HIV-1 Patients. Mediators of inflammation\| PubMed ID: 26696749	2015
Polyanionic Macromolecular Prodrugs of Ribavirin: Antiviral Agents with a Broad Spectrum of Activity. Advanced healthcare materials\| PubMed ID: 26789641	2016
ART influences HIV persistence in the female reproductive tract and cervicovaginal secretions. The Journal of clinical investigation\| PubMed ID: 26854925	2016
Using animal models to overcome temporal, spatial and combinatorial challenges in HIV persistence research. Journal of translational medicine\| PubMed ID: 26861779	2016
A Novel Toll-Like Receptor 9 Agonist, MGN1703, Enhances HIV-1 Transcription and NK Cell-Mediated Inhibition of HIV-1-Infected Autologous CD4+ T Cells. Journal of virology\| PubMed ID: 26889036	2016
Human Papillomavirus neutralizing and cross-reactive antibodies induced in HIV-positive subjects after vaccination with quadrivalent and bivalent HPV vaccines. Vaccine\| PubMed ID: 26896686	2016
The potential role for romidepsin as a component in early HIV-1 curative efforts. Expert review of anti-infective therapy\| PubMed ID: 26953620	2016
New insights on the phenotype of HIV reservoirs. AIDS (London, England)\| PubMed ID: 27243776	2016
Triple Activity of Lamivudine Releasing Sulfonated Polymers against HIV-1. Molecular pharmaceutics\| PubMed ID: 27244595	2016
International AIDS Society global scientific strategy: towards an HIV cure 2016. Nature medicine\| PubMed ID: 27400264	2016
Immune checkpoints and the HIV-1 reservoir: proceed with caution. Journal of virus eradication\| PubMed ID: 27482460	2016
Modeling of Experimental Data Supports HIV Reactivation from Latency after Treatment Interruption on Average Once Every 5-8 Days. PLoS pathogens\| PubMed ID: 27560972	2016
Broad activation of latent HIV-1 in vivo. Nature communications\| PubMed ID: 27605062	2016
Combined effect of Vacc-4x, recombinant human granulocyte macrophage colony-stimulating factor vaccination, and romidepsin on the HIV-1 reservoir (REDUC): a single-arm, phase 1B/2A trial. The lancet. HIV\| PubMed ID: 27658863	2016
Macromolecular Prodrugs of Ribavirin: Structure-Function Correlation as Inhibitors of Influenza Infectivity. Molecular pharmaceutics\| PubMed ID: 28043136	2017
Romidepsin-induced HIV-1 viremia during effective antiretroviral therapy contains identical viral sequences with few deleterious mutations. AIDS (London, England)\| PubMed ID: 28272134	2017
Beyond antiretroviral therapy: early interventions to control HIV-1 infection. AIDS (London, England)\| PubMed ID: 28463884	2017
Anti-HIV-1 ADCC Antibodies following Latency Reversal and Treatment Interruption. Journal of virology\| PubMed ID: 28539449	2017
Macromolecular prodrugs of ribavirin: towards a treatment for co-infection with HIV and HCV. Chemical science\| PubMed ID: 28580095	2015
The TLR9 agonist MGN1703 triggers a potent type I interferon response in the sigmoid colon. Mucosal immunology\| PubMed ID: 28766555	2018
HDAC inhibition induces HIV-1 protein and enables immune-based clearance following latency reversal. JCI insight\| PubMed ID: 28814661	2017
Macromolecular Antiviral Agents against Zika, Ebola, SARS, and Other Pathogenic Viruses. Advanced healthcare materials\| PubMed ID: 28945945	2017
Estimating Initial Viral Levels during Simian Immunodeficiency Virus/Human Immunodeficiency Virus Reactivation from Latency. Journal of virology\| PubMed ID: 29118123	2018
Cellular immunogenicity of human papillomavirus vaccines Cervarix and Gardasil in adults with HIV infection. Human vaccines & immunotherapeutics\| PubMed ID: 29172992	2018
Macromolecular prodrugs of ribavirin: Polymer backbone defines blood safety, drug release, and efficacy of anti-inflammatory effects. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 29432822	2018
Treatment of HIV-Infected Individuals with the Histone Deacetylase Inhibitor Panobinostat Results in Increased Numbers of Regulatory T Cells and Limits Lipopolysaccharide-Induced Inflammato... mSphere\| PubMed ID: 29468194	2018
Levels of regulatory B cells do not predict serological responses to hepatitis B vaccine. Human vaccines & immunotherapeutics\| PubMed ID: 29474139	2018
Multiple Homozygous Variants in the STING-Encoding Gene in HIV Long-Term Nonprogressors. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 29632140	2018
Genetic characterization of the HIV-1 reservoir after Vacc-4x and romidepsin therapy in HIV-1-infected individuals. AIDS (London, England)\| PubMed ID: 29762162	2018
HIV anti-latency treatment mediated by macromolecular prodrugs of histone deacetylase inhibitor, panobinostat. Chemical science\| PubMed ID: 29997778	2016
Differences in antiretroviral regimens do not impact safety or level of latency reversal in persons receiving romidepsin. AIDS (London, England)\| PubMed ID: 30001247	2018
Whole Exome Sequencing of HIV-1 long-term non-progressors identifies rare variants in genes encoding innate immune sensors and signaling molecules. Scientific reports\| PubMed ID: 30323326	2018
Characterization of the HIV-1 transcription profile after romidepsin administration in ART-suppressed individuals. AIDS (London, England)\| PubMed ID: 30531314	2019
Non-covalent hitchhiking on endogenous carriers as a protraction mechanism for antiviral macromolecular prodrugs. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 30552954	2019
Characterization of Intact Proviruses in Blood and Lymph Node from HIV-Infected Individuals Undergoing Analytical Treatment Interruption. Journal of virology\| PubMed ID: 30700598	2019
In-vivo administration of histone deacetylase inhibitors does not impair natural killer cell function in HIV+ individuals. AIDS (London, England)\| PubMed ID: 30830886	2019
cAIMP administration in humanized mice induces a chimerization-level-dependent STING response. Immunology\| PubMed ID: 30919991	2019
Effects of 24-week Toll-like receptor 9 agonist treatment in HIV type 1+ individuals. AIDS (London, England)\| PubMed ID: 30932955	2019
Nucleic Acids as a Nature-Inspired Scaffold for Macromolecular Prodrugs of Nucleoside Analogues. Advanced science (Weinheim, Baden-Wurttemberg, Germany)\| PubMed ID: 30937274	2019
TLR9 agonist MGN1703 enhances B cell differentiation and function in lymph nodes. EBioMedicine\| PubMed ID: 31300344	2019
IL-1R3 blockade broadly attenuates the functions of six members of the IL-1 family, revealing their contribution to models of disease. Nature immunology\| PubMed ID: 31427775	2019
Impacts of HIV Cure Interventions on Viral Reservoirs in Tissues. Frontiers in microbiology\| PubMed ID: 31497010	2019
Fimepinostat, a novel dual inhibitor of HDAC and PI3K, effectively reverses HIV-1 latency without T cell activation. Journal of virus eradication\| PubMed ID: 31700655	2019
Fimepinostat, a novel dual inhibitor of HDAC and PI3K, effectively reverses HIV-1 latency without T cell activation. Journal of virus eradication\| PubMed ID: 31700656	2019