Rakesh Karmacharya

Center for Genomic Medicine, Massachusetts General Hospital

Affiliated withMassachusetts General Hospital Broad Institute of MIT and Harvard Harvard Medical School

Research Area

Biography

Dr. Karmacharya is working at the intersection of chemical biology and stem cell biology to investigate the cellular-molecular underpinnings of psychiatric disorders

JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 12	2020
Publication title Cited by 18	2021

Other Publications

Article	Year
Principles and neurobiological correlates of concentrative, diffuse, and insight meditation. Harvard review of psychiatry\| PubMed ID: 24651509	2013
HDAC6 inhibitors modulate Lys49 acetylation and membrane localization of β-catenin in human iPSC-derived neuronal cells. ACS chemical biology\| PubMed ID: 25546293	2015
Niche-Based Screening in Multiple Myeloma Identifies a Kinesin-5 Inhibitor with Improved Selectivity over Hematopoietic Progenitors. Cell reports\| PubMed ID: 25660025	2015
Effects of LEP, LEPR, ADIPOQ, MC4R and FTO polymorphisms on dyslipidemia in Korean patients with schizophrenia who are taking clozapine. Psychiatry research\| PubMed ID: 25841316	2015
Disease signatures for schizophrenia and bipolar disorder using patient-derived induced pluripotent stem cells. Molecular and cellular neurosciences\| PubMed ID: 26777134	2016
Stem cell models of neuropsychiatric disorders. Molecular and cellular neurosciences\| PubMed ID: 27013423	2016
Gene Expression-Based Screen for Parkinson's Disease Identifies GW8510 as a Neuroprotective Agent. ACS chemical neuroscience\| PubMed ID: 27270122	2016
Perturbational Profiling of Metabolites in Patient Fibroblasts Implicates α-Aminoadipate as a Potential Biomarker for Bipolar Disorder. Molecular neuropsychiatry\| PubMed ID: 27606323	2016
Unbiased Metabolite Profiling of Schizophrenia Fibroblasts under Stressful Perturbations Reveals Dysregulation of Plasmalogens and Phosphatidylcholines. Journal of proteome research\| PubMed ID: 28152600	2017
Stem cell-derived neurons in the development of targeted treatment for schizophrenia and bipolar disorder. Pharmacogenomics\| PubMed ID: 28346060	2017
Lysine Deacetylation by HDAC6 Regulates the Kinase Activity of AKT in Human Neural Progenitor Cells. ACS chemical biology\| PubMed ID: 28628306	2017
Increased synapse elimination by microglia in schizophrenia patient-derived models of synaptic pruning. Nature neuroscience\| PubMed ID: 30718903	2019
Identifying depression early in adolescence. The Lancet. Child & adolescent health\| PubMed ID: 30878111	2019
HDAC6 Modulates Signaling Pathways Relevant to Synaptic Biology and Neuronal Differentiation in Human Stem-Cell-Derived Neurons. International journal of molecular sciences\| PubMed ID: 30935091	2019
Protocol for a systematic review of the development of depression among adolescents and young adults: psychological, biological, and contextual perspectives around the world. Systematic reviews\| PubMed ID: 31325965	2019
Synaptic deficits in iPSC-derived cortical interneurons in schizophrenia are mediated by NLGN2 and rescued by N-acetylcysteine. Translational psychiatry\| PubMed ID: 31780643	2019
Transcriptomic Landscape and Functional Characterization of Induced Pluripotent Stem Cell-Derived Cerebral Organoids in Schizophrenia. JAMA psychiatry\| PubMed ID: 32186681	2020
Transcriptome analysis and functional characterization of cerebral organoids in bipolar disorder. Genome medicine\| PubMed ID: 32306996	2020
Integrating stem cell-based experiments in clinical research. European psychiatry : the journal of the Association of European Psychiatrists\| PubMed ID: 32536357	2020
Advances toward precision medicine for bipolar disorder: mechanisms & molecules. Molecular psychiatry\| PubMed ID: 32636474	2020
Mental Health Units in Correctional Facilities in the United States. Harvard review of psychiatry\| PubMed ID: 32692089	2020
Comparative Transcriptomic Analysis of Cerebral Organoids and Cortical Neuron Cultures Derived from Human Induced Pluripotent Stem Cells. Stem cells and development\| PubMed ID: 32862797	2020
A systematic review of the association between biological markers and environmental stress risk factors for adolescent depression. Journal of psychiatric research\| PubMed ID: 33857787	2021
The Identifying Depression Early in Adolescence Risk Stratified Cohort (IDEA-RiSCo): Rationale, Methods, and Baseline Characteristics. Frontiers in psychiatry\| PubMed ID: 34234702	2021