Susan R. Weiss

Department of Microbiology, University of Pennsylvania

Affiliated withUniversity of Pennsylvania

Research Area

Biography

i have been wroking on coronavirus replication and pathogenesis for forty years.

JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 6	2023

Other Publications

Article	Year
Intracellular processing of the N-terminal ORF 1a proteins of the coronavirus MHV-A59 requires multiple proteolytic events. Virology\| PubMed ID: 1318604	1992
Mouse hepatitis virus A59 increases steady-state levels of MHC mRNAs in primary glial cell cultures and in the murine central nervous system. Microbial pathogenesis\| PubMed ID: 1338798	1992
Mouse hepatitis virus ORF 2a is expressed in the cytosol of infected mouse fibroblasts. Virology\| PubMed ID: 2154893	1990
Induction of MHC class I antigens on glial cells is dependent on persistent mouse hepatitis virus infection. Journal of neuroimmunology\| PubMed ID: 2538490	1989
Molecular cloning of the gene encoding the putative polymerase of mouse hepatitis coronavirus, strain A59. Virology\| PubMed ID: 2545027	1989
A general method for the induction and screening of antisera for cDNA-encoded polypeptides: antibodies specific for a coronavirus putative polymerase-encoding gene. Gene\| PubMed ID: 2560756	1989
Detection of a murine coronavirus nonstructural protein encoded in a downstream open reading frame. Virology\| PubMed ID: 2834866	1988
Coronavirus mouse hepatitis virus (MHV)-A59 causes a persistent, productive infection in primary glial cell cultures. Microbial pathogenesis\| PubMed ID: 2849019	1987
In vitro synthesis of two polypeptides from a nonstructural gene of coronavirus mouse hepatitis virus strain A59. Virology\| PubMed ID: 3029985	1987
Coronaviruses SD and SK share extensive nucleotide homology with murine coronavirus MHV-A59, more than that shared between human and murine coronaviruses. Virology\| PubMed ID: 6687965	1983
Mouse hepatitis virus A59-induced demyelination can occur in the absence of CD8+ T cells. Microbial pathogenesis\| PubMed ID: 7565015	1995
Identification and characterization of a 65-kDa protein processed from the gene 1 polyprotein of the murine coronavirus MHV-A59. Virology\| PubMed ID: 7871746	1995
Mouse hepatitis virus strain A59 RNA polymerase gene ORF 1a: heterogeneity among MHV strains. Virology\| PubMed ID: 8291254	1994
The ns 4 gene of mouse hepatitis virus (MHV), strain A 59 contains two ORFs and thus differs from ns 4 of the JHM and S strains. Archives of virology\| PubMed ID: 8385918	1993
Syncytia formation induced by coronavirus infection is associated with fragmentation and rearrangement of the Golgi apparatus. Virology\| PubMed ID: 8661443	1996
Efficient autoproteolytic processing of the MHV-A59 3C-like proteinase from the flanking hydrophobic domains requires membranes. Virology\| PubMed ID: 9143287	1997
Altered pathogenesis of a mutant of the murine coronavirus MHV-A59 is associated with a Q159L amino acid substitution in the spike protein. Virology\| PubMed ID: 9426441	1997
The spike protein of murine coronavirus mouse hepatitis virus strain A59 is not cleaved in primary glial cells and primary hepatocytes. Journal of virology\| PubMed ID: 9445064	1998
Roles in cell-to-cell fusion of two conserved hydrophobic regions in the murine coronavirus spike protein. Virology\| PubMed ID: 9601516	1998
Targeted recombination within the spike gene of murine coronavirus mouse hepatitis virus-A59: Q159 is a determinant of hepatotropism. Journal of virology\| PubMed ID: 9811696	1998
Cellular reservoirs for coronavirus infection of the brain in beta2-microglobulin knockout mice. Pathobiology : journal of immunopathology, molecular and cellular biology\| PubMed ID: 10023135	1999
Expression of murine coronavirus recombinant papain-like proteinase: efficient cleavage is dependent on the lengths of both the substrate and the proteinase polypeptides. Journal of virology\| PubMed ID: 10074111	1999
Pathogenesis of chimeric MHV4/MHV-A59 recombinant viruses: the murine coronavirus spike protein is a major determinant of neurovirulence. Journal of virology\| PubMed ID: 10438865	1999
Amino acid substitutions within the leucine zipper domain of the murine coronavirus spike protein cause defects in oligomerization and the ability to induce cell-to-cell fusion. Journal of virology\| PubMed ID: 10482565	1999
Further requirements for cleavage by the murine coronavirus 3C-like proteinase: identification of a cleavage site within ORF1b. Virology\| PubMed ID: 10544119	1999
Demyelination determinants map to the spike glycoprotein gene of coronavirus mouse hepatitis virus. Journal of virology\| PubMed ID: 10982367	2000
Murine coronavirus spike protein determines the ability of the virus to replicate in the liver and cause hepatitis. Journal of virology\| PubMed ID: 11160748	2001
Multiple regions of the murine coronavirus spike glycoprotein influence neurovirulence. Journal of neurovirology\| PubMed ID: 11582514	2001
Further in vitro characterization of mouse hepatitis virus papain-like proteinase 1: cleavage sequence requirements within pp1a. Journal of neurovirology\| PubMed ID: 11935466	2002
Murine coronavirus spike glycoprotein mediates degree of viral spread, inflammation, and virus-induced immunopathology in the central nervous system. Virology\| PubMed ID: 12359451	2002
Systematic assembly of a full-length infectious cDNA of mouse hepatitis virus strain A59. Journal of virology\| PubMed ID: 12368349	2002
Perforin-mediated CTL cytolysis counteracts direct cell-cell spread of Listeria monocytogenes. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 12391238	2002
Enhanced green fluorescent protein expression may be used to monitor murine coronavirus spread in vitro and in the mouse central nervous system. Journal of neurovirology\| PubMed ID: 12402164	2002
The virulence of mouse hepatitis virus strain A59 is not dependent on efficient spike protein cleavage and cell-to-cell fusion. Journal of neurovirology\| PubMed ID: 12402166	2002
Conformational changes in the spike glycoprotein of murine coronavirus are induced at 37 degrees C either by soluble murine CEACAM1 receptors or by pH 8. Journal of virology\| PubMed ID: 12502799	2003
The N-terminal domain of the murine coronavirus spike glycoprotein determines the CEACAM1 receptor specificity of the virus strain. Journal of virology\| PubMed ID: 12502800	2003
Murine coronavirus-induced hepatitis: JHM genetic background eliminates A59 spike-determined hepatotropism. Journal of virology\| PubMed ID: 12663803	2003
Amino acid substitutions within the heptad repeat domain 1 of murine coronavirus spike protein restrict viral antigen spread in the central nervous system. Virology\| PubMed ID: 12919742	2003
The glycosylation status of the murine hepatitis coronavirus M protein affects the interferogenic capacity of the virus in vitro and its ability to replicate in the liver but not the brain. Virology\| PubMed ID: 12919744	2003
Effects of an epitope-specific CD8+ T-cell response on murine coronavirus central nervous system disease: protection from virus replication and antigen spread and selection of epitope escape... Journal of virology\| PubMed ID: 14722270	2004
SARS: lessons learned from other coronaviruses. Viral immunology\| PubMed ID: 14733734	2003
Coronavirus replication and pathogenesis: Implications for the recent outbreak of severe acute respiratory syndrome (SARS), and the challenge for vaccine development. Journal of neurovirology\| PubMed ID: 15204926	2004
Increased epitope-specific CD8+ T cells prevent murine coronavirus spread to the spinal cord and subsequent demyelination. Journal of virology\| PubMed ID: 15731231	2005
Single-amino-acid substitutions in open reading frame (ORF) 1b-nsp14 and ORF 2a proteins of the coronavirus mouse hepatitis virus are attenuating in mice. Journal of virology\| PubMed ID: 15731233	2005
Identification of murine CD8 T cell epitopes in codon-optimized SARS-associated coronavirus spike protein. Virology\| PubMed ID: 15823604	2005
Murine coronavirus evolution in vivo: functional compensation of a detrimental amino acid substitution in the receptor binding domain of the spike glycoprotein. Journal of virology\| PubMed ID: 15919915	2005
Expression and purification of SARS coronavirus proteins using SUMO-fusions. Protein expression and purification\| PubMed ID: 15939295	2005
Contributions of the viral genetic background and a single amino acid substitution in an immunodominant CD8+ T-cell epitope to murine coronavirus neurovirulence. Journal of virology\| PubMed ID: 15994805	2005
Enhanced expression and purification of membrane proteins by SUMO fusion in Escherichia coli. Journal of structural and functional genomics\| PubMed ID: 16211506	2005
Expression of hemagglutinin esterase protein from recombinant mouse hepatitis virus enhances neurovirulence. Journal of virology\| PubMed ID: 16306577	2005
Coronavirus pathogenesis and the emerging pathogen severe acute respiratory syndrome coronavirus. Microbiology and molecular biology reviews : MMBR\| PubMed ID: 16339739	2005
Endosomal proteolysis by cathepsins is necessary for murine coronavirus mouse hepatitis virus type 2 spike-mediated entry. Journal of virology\| PubMed ID: 16731916	2006
Both spike and background genes contribute to murine coronavirus neurovirulence. Journal of virology\| PubMed ID: 16809289	2006
CD8+ T-cell priming during a central nervous system infection with mouse hepatitis virus. Advances in experimental medicine and biology\| PubMed ID: 17037564	2006
Murine hepatitis virus strain 1 produces a clinically relevant model of severe acute respiratory syndrome in A/J mice. Journal of virology\| PubMed ID: 17041219	2006
Replicase genes of murine coronavirus strains A59 and JHM are interchangeable: differences in pathogenesis map to the 3' one-third of the genome. Journal of virology\| PubMed ID: 17079303	2007
Inhibition of the alpha/beta interferon response by mouse hepatitis virus at multiple levels. Journal of virology\| PubMed ID: 17459917	2007
The spike glycoprotein of murine coronavirus MHV-JHM mediates receptor-independent infection and spread in the central nervous systems of Ceacam1a-/- Mice. Journal of virology\| PubMed ID: 18003729	2008
The SARS-CoV ferret model in an infection-challenge study. Virology\| PubMed ID: 18234270	2008
Chemokine expression during mouse-hepatitis-virus-induced encephalitis: contributions of the spike and background genes. Journal of neurovirology\| PubMed ID: 18300071	2008
Demyelinating and nondemyelinating strains of mouse hepatitis virus differ in their neural cell tropism. Journal of virology\| PubMed ID: 18385249	2008
Priming of CD8+ T cells during central nervous system infection with a murine coronavirus is strain dependent. Journal of virology\| PubMed ID: 18417581	2008
Murine coronavirus mouse hepatitis virus is recognized by MDA5 and induces type I interferon in brain macrophages/microglia. Journal of virology\| PubMed ID: 18667505	2008
Organ-specific attenuation of murine hepatitis virus strain A59 by replacement of catalytic residues in the putative viral cyclic phosphodiesterase ns2. Journal of virology\| PubMed ID: 19176619	2009
The murine coronavirus nucleocapsid gene is a determinant of virulence. Journal of virology\| PubMed ID: 20007284	2010
Murine Coronavirus Cell Type Dependent Interaction with the Type I Interferon Response. Viruses\| PubMed ID: 20221421	2009
Murine coronavirus delays expression of a subset of interferon-stimulated genes. Journal of virology\| PubMed ID: 20357099	2010
Pathogenesis of murine coronavirus in the central nervous system. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology\| PubMed ID: 20369302	2010
Genetic determinants of mouse hepatitis virus strain 1 pneumovirulence. Journal of virology\| PubMed ID: 20631137	2010
Murine coronavirus receptors are differentially expressed in the central nervous system and play virus strain-dependent roles in neuronal spread. Journal of virology\| PubMed ID: 20739537	2010
Murine coronavirus neuropathogenesis: determinants of virulence. Journal of neurovirology\| PubMed ID: 21073281	2010
Pathogenesis of neurotropic murine coronavirus is multifactorial. Trends in pharmacological sciences\| PubMed ID: 21144598	2011
Characteristics of opioid prescriptions in 2009. JAMA\| PubMed ID: 21467282	2011
Cell-type-specific type I interferon antagonism influences organ tropism of murine coronavirus. Journal of virology\| PubMed ID: 21752905	2011
The role of interferon antagonist, non-structural proteins in the pathogenesis and emergence of arboviruses. Viruses\| PubMed ID: 21994750	2011
Coronavirus pathogenesis. Advances in virus research\| PubMed ID: 22094080	2011
A novel full-length isoform of murine pregnancy-specific glycoprotein 16 (psg16) is expressed in the brain but does not mediate murine coronavirus (MHV) entry. Journal of neurovirology\| PubMed ID: 22302612	2012
Antagonism of the interferon-induced OAS-RNase L pathway by murine coronavirus ns2 protein is required for virus replication and liver pathology. Cell host & microbe\| PubMed ID: 22704621	2012
Novel inhibitors of severe acute respiratory syndrome coronavirus entry that act by three distinct mechanisms. Journal of virology\| PubMed ID: 23678171	2013
Cell-type-specific activation of the oligoadenylate synthetase-RNase L pathway by a murine coronavirus. Journal of virology\| PubMed ID: 23698313	2013
Homologous 2',5'-phosphodiesterases from disparate RNA viruses antagonize antiviral innate immunity. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23878220	2013
Analysis of the host transcriptome from demyelinating spinal cord of murine coronavirus-infected mice. PloS one\| PubMed ID: 24058676	2013
Cell-type-specific effects of RNase L on viral induction of beta interferon. mBio\| PubMed ID: 24570368	2014
Evaluation of SSYA10-001 as a replication inhibitor of severe acute respiratory syndrome, mouse hepatitis, and Middle East respiratory syndrome coronaviruses. Antimicrobial agents and chemotherapy\| PubMed ID: 24841268	2014
Viral phosphodiesterases that antagonize double-stranded RNA signaling to RNase L by degrading 2-5A. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research\| PubMed ID: 24905202	2014
Murine AKAP7 has a 2',5'-phosphodiesterase domain that can complement an inactive murine coronavirus ns2 gene. mBio\| PubMed ID: 24987090	2014
Coronavirus-induced demyelination of neural pathways triggers neurogenic bladder overactivity in a mouse model of multiple sclerosis. American journal of physiology. Renal physiology\| PubMed ID: 25007876	2014
The nsp1, nsp13, and M proteins contribute to the hepatotropism of murine coronavirus JHM.WU. Journal of virology\| PubMed ID: 25589656	2015
Structural basis for 2'-5'-oligoadenylate binding and enzyme activity of a viral RNase L antagonist. Journal of virology\| PubMed ID: 25878106	2015
MDA5 Is Critical to Host Defense during Infection with Murine Coronavirus. Journal of virology\| PubMed ID: 26423942	2015
RNase L is a negative regulator of cell migration. Oncotarget\| PubMed ID: 26517238	2015
Activation of RNase L by Murine Coronavirus in Myeloid Cells Is Dependent on Basal Oas Gene Expression and Independent of Virus-Induced Interferon. Journal of virology\| PubMed ID: 26739051	2016
Crystal structure of the mouse hepatitis virus ns2 phosphodiesterase domain that antagonizes RNase L activation. The Journal of general virology\| PubMed ID: 26757803	2016
Primary Role for Toll-Like Receptor-Driven Tumor Necrosis Factor Rather than Cytosolic Immune Detection in Restricting Coxiella burnetii Phase II Replication within Mouse Macrophages. Infection and immunity\| PubMed ID: 26787725	2016
Activation of RNase L is dependent on OAS3 expression during infection with diverse human viruses. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 26858407	2016
Middle East Respiratory Syndrome Coronavirus NS4b Protein Inhibits Host RNase L Activation. mBio\| PubMed ID: 27025250	2016
Antagonism of RNase L Is Required for Murine Coronavirus Replication in Kupffer Cells and Liver Sinusoidal Endothelial Cells but Not in Hepatocytes. Journal of virology\| PubMed ID: 27558415	2016
Lineage A Betacoronavirus NS2 Proteins and the Homologous Torovirus Berne pp1a Carboxy-Terminal Domain Are Phosphodiesterases That Antagonize Activation of RNase L. Journal of virology\| PubMed ID: 28003490	2017
Neurovirulent Murine Coronavirus JHM.SD Uses Cellular Zinc Metalloproteases for Virus Entry and Cell-Cell Fusion. Journal of virology\| PubMed ID: 28148786	2017
Early endonuclease-mediated evasion of RNA sensing ensures efficient coronavirus replication. PLoS pathogens\| PubMed ID: 28158275	2017
Ribonuclease L mediates the cell-lethal phenotype of double-stranded RNA editing enzyme ADAR1 deficiency in a human cell line. eLife\| PubMed ID: 28362255	2017
Role of the inflammasome-related cytokines Il-1 and Il-18 during infection with murine coronavirus. Journal of neurovirology\| PubMed ID: 28895072	2017
Replication defective viral genomes exploit a cellular pro-survival mechanism to establish paramyxovirus persistence. Nature communications\| PubMed ID: 28986577	2017
Origins and pathogenesis of Middle East respiratory syndrome-associated coronavirus: recent advances. F1000Research\| PubMed ID: 29026532	2017
Murine Hepatitis Virus nsp14 Exoribonuclease Activity Is Required for Resistance to Innate Immunity. Journal of virology\| PubMed ID: 29046453	2018
A novel mechanism of RNase L inhibition: Theiler's virus L* protein prevents 2-5A from binding to RNase L. PLoS pathogens\| PubMed ID: 29652922	2018
Third Tofo Advanced Study Week on Emerging and Re-emerging Viruses, 2018. Antiviral research\| PubMed ID: 30597184	2019
Real-time 2-5A kinetics suggest that interferons β and λ evade global arrest of translation by RNase L. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 30655338	2019
OAS-RNase L innate immune pathway mediates the cytotoxicity of a DNA-demethylating drug. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 30814222	2019
Antagonism of dsRNA-Induced Innate Immune Pathways by NS4a and NS4b Accessory Proteins during MERS Coronavirus Infection. mBio\| PubMed ID: 30914508	2019
Zika Virus Production Is Resistant to RNase L Antiviral Activity. Journal of virology\| PubMed ID: 31142667	2019
Activation of RNase L in Egyptian Rousette Bat-Derived RoNi/7 Cells Is Dependent Primarily on OAS3 and Independent of MAVS Signaling. mBio\| PubMed ID: 31719180	2019
No credible evidence supporting claims of the laboratory engineering of SARS-CoV-2. Emerging microbes & infections\| PubMed ID: 32102621	2020
Forty years with coronaviruses. The Journal of experimental medicine\| PubMed ID: 32232339	2020
Broad Anti-coronavirus Activity of Food and Drug Administration-Approved Drugs against SARS-CoV-2 and SARS-CoV . Journal of virology\| PubMed ID: 32817221	2020
A phenolic small molecule inhibitor of RNase L prevents cell death from ADAR1 deficiency. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 32958664	2020
Physiologic RNA targets and refined sequence specificity of coronavirus EndoU. RNA (New York, N.Y.)\| PubMed ID: 32989044	2020
SARS-CoV-2 Genomic Variation in Space and Time in Hospitalized Patients in Philadelphia. mBio\| PubMed ID: 33468702	2021
Molecular determinants and mechanism for antibody cocktail preventing SARS-CoV-2 escape. Nature communications\| PubMed ID: 33473140	2021
Copan eNAT Transport System To Address Challenges in COVID-19 Diagnostics in Regions with Limited Testing Access. Journal of clinical microbiology\| PubMed ID: 33579730	2021
Activation of STING Signaling Pathway Effectively Blocks Human Coronavirus Infection. Journal of virology\| PubMed ID: 33789998	2021
Femtomolar SARS-CoV-2 Antigen Detection Using the Microbubbling Digital Assay with Smartphone Readout Enables Antigen Burden Quantitation and Dynamics Tracking. medRxiv : the preprint server for health sciences\| PubMed ID: 33791710	2021
SARS-CoV-2 induces double-stranded RNA-mediated innate immune responses in respiratory epithelial-derived cells and cardiomyocytes. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 33811184	2021
Discrimination of SARS-CoV-2 infected patient samples by detection dogs: A proof of concept study. PloS one\| PubMed ID: 33852639	2021
Zika virus employs the host antiviral RNase L protein to support replication factory assembly. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 34031250	2021
Detection of SARS-CoV-2 RNA using RT-LAMP and molecular beacons. Genome biology\| PubMed ID: 34082799	2021
Author Correction: Molecular determinants and mechanism for antibody cocktail preventing SARS-CoV-2 escape. Nature communications\| PubMed ID: 34210985	2021
Femtomolar SARS-CoV-2 Antigen Detection Using the Microbubbling Digital Assay with Smartphone Readout Enables Antigen Burden Quantitation and Tracking. Clinical chemistry\| PubMed ID: 34383886	2021
Multiplexed detection of SARS-CoV-2 genomic and subgenomic RNA using hybridization. bioRxiv : the preprint server for biology\| PubMed ID: 34401878	2021
The origins of SARS-CoV-2: A critical review. Cell\| PubMed ID: 34480864	2021
Single- and Two-Stage, Closed-Tube, Point-of-Care, Molecular Detection of SARS-CoV-2. Analytical chemistry\| PubMed ID: 34541844	2021
Adenovirus prevents dsRNA formation by promoting efficient splicing of viral RNA. Nucleic acids research\| PubMed ID: 34671803	2022
Subcellular Detection of SARS-CoV-2 RNA in Human Tissue Reveals Distinct Localization in Alveolar Type 2 Pneumocytes and Alveolar Macrophages. mBio\| PubMed ID: 35130722	2021
Detection and Interspecies Comparison of SARS-CoV-2 Delta Variant (AY.3) in Feces from a Domestic Cat and Human Samples. bioRxiv : the preprint server for biology\| PubMed ID: 35132417	2022
SARS-CoV-2 Delta Variant (AY.3) in the Feces of a Domestic Cat. Viruses\| PubMed ID: 35216014	2022
MERS-CoV endoribonuclease and accessory proteins jointly evade host innate immunity during infection of lung and nasal epithelial cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 35594398	2022
SARS-CoV-2 diverges from other betacoronaviruses in only partially activating the IRE1α/XBP1 ER stress pathway in human lung-derived cells. bioRxiv : the preprint server for biology\| PubMed ID: 35821981	2022
Targeted Mutations in the Fusion Peptide Region of La Crosse Virus Attenuate Neuroinvasion and Confer Protection against Encephalitis. Viruses\| PubMed ID: 35891445	2022
SARS-CoV-2 disrupts host epigenetic regulation via histone mimicry. Nature\| PubMed ID: 36198800	2022
Infection of primary nasal epithelial cells differentiates among lethal and seasonal human coronaviruses. bioRxiv : the preprint server for biology\| PubMed ID: 36299422	2022
Inborn errors of OAS-RNase L in SARS-CoV-2-related multisystem inflammatory syndrome in children. Science (New York, N.Y.)\| PubMed ID: 36538032	2023
Publisher Correction: SARS-CoV-2 disrupts host epigenetic regulation via histone mimicry. Nature\| PubMed ID: 36624294	2023
Author Correction: SARS-CoV-2 disrupts host epigenetic regulation via histone mimicry. Nature\| PubMed ID: 36747034	2023
Infection of primary nasal epithelial cells differentiates among lethal and seasonal human coronaviruses. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 37023127	2023
Detection of blood-brain barrier disruption in brains of patients with COVID-19, but no evidence of brain penetration by SARS-CoV-2. Acta neuropathologica\| PubMed ID: 37624381	2023
Comparison of SARS-CoV-2 variants in primary human nasal cultures indicates Delta as most cytopathic and Omicron as fastest replicating. bioRxiv : the preprint server for biology\| PubMed ID: 37662273	2023