Howard L. Weiner

Center for Neurologic Diseases, Harvard Medical School

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 3	Year
Publication title Cited by 37	2012
Publication title	2020
Publication title Cited by 7	2019

Other Publications

Article	Year
PloS one\| PubMed ID: 20221429	2010
Immunology. How does the immune system tolerate food? Science (New York, N.Y.)\| PubMed ID: 26912876	2016
Oral tolerance, an active immunologic process mediated by multiple mechanisms. The Journal of clinical investigation\| PubMed ID: 11032852	2000
CNS drugs\| PubMed ID: 11772115	2002
International immunology\| PubMed ID: 11809732	2002
Journal of magnetic resonance imaging : JMRI\| PubMed ID: 11836778	2002
Neurosurgery\| PubMed ID: 11904022	2002
European journal of immunology\| PubMed ID: 11920578	2002
Journal of neuroimmunology\| PubMed ID: 11960649	2002
Plastic and reconstructive surgery\| PubMed ID: 11994607	2002
Journal of neuroimmunology\| PubMed ID: 12020972	2002
Clinical immunology (Orlando, Fla.)\| PubMed ID: 12027417	2002
Nature medicine\| PubMed ID: 16715091	2006
Cutting edge: oral type I IFN-tau promotes a Th2 bias and enhances suppression of autoimmune encephalomyelitis by oral glatiramer acetate. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 12193686	2002
Circulation\| PubMed ID: 12270867	2002
Cancer research\| PubMed ID: 12438220	2002
The American journal of pathology\| PubMed ID: 12466141	2002
Nature\| PubMed ID: 12490962	2002
Journal of child neurology\| PubMed ID: 12503646	2002
Induction of low dose oral tolerance in monocyte chemoattractant protein-1- and CCR2-deficient mice. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 12594253	2003
Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 12594277	2003
Neurology\| PubMed ID: 12601106	2003
Journal of autoimmunity\| PubMed ID: 12657527	2003
FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 12724345	2003
Markers of cellular proliferation are expressed in cortical tubers. Annals of neurology\| PubMed ID: 12731003	2003
Myelin oligodendrocyte glycoprotein-specific T cell receptor transgenic mice develop spontaneous autoimmune optic neuritis. The Journal of experimental medicine\| PubMed ID: 12732654	2003
Journal of pediatric hematology/oncology\| PubMed ID: 12759623	2003
Increased T cell reactivity to amyloid beta protein in older humans and patients with Alzheimer disease. The Journal of clinical investigation\| PubMed ID: 12897209	2003
Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 12928365	2003
Journal of autoimmunity\| PubMed ID: 12935782	2003
Science (New York, N.Y.)\| PubMed ID: 14593170	2003
Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 14662856	2003
IFN-inducible protein 10/CXC chemokine ligand 10-independent induction of experimental autoimmune encephalomyelitis. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 14688366	2004
Journal of neuroimmunology\| PubMed ID: 14698862	2004
Immunologic research\| PubMed ID: 14713719	2003
International immunology\| PubMed ID: 14734610	2004
Pediatric clinics of North America\| PubMed ID: 15062675	2004
The Journal of experimental medicine\| PubMed ID: 15067033	2004
Journal of neuroimaging : official journal of the American Society of Neuroimaging\| PubMed ID: 15228759	2004
Journal of the neurological sciences\| PubMed ID: 15261554	2004
Epilepsia\| PubMed ID: 15281957	2004
Archives of neurology\| PubMed ID: 15477521	2004
Induction of low dose oral tolerance in IL-10 deficient mice with experimental autoimmune encephalomyelitis. Journal of autoimmunity\| PubMed ID: 15501390	2004
Development of a safe oral Abeta vaccine using recombinant adeno-associated virus vector for Alzheimer's disease. Journal of Alzheimer's disease : JAD\| PubMed ID: 15505369	2004
Journal of child neurology\| PubMed ID: 15563015	2004
Cellular immunology\| PubMed ID: 15598424	2004
Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 15611503	2004
Neurologic clinics\| PubMed ID: 15661097	2005
Neurosurgery\| PubMed ID: 15670380	2005
Annals of the New York Academy of Sciences\| PubMed ID: 15681760	2004
Archives of neurology\| PubMed ID: 15883268	2005
Journal of neuroimmunology\| PubMed ID: 15885317	2005
Journal of the neurological sciences\| PubMed ID: 15894335	2005
Journal of neurosurgery\| PubMed ID: 16028775	2005
Immunological reviews\| PubMed ID: 16048553	2005
The Journal of clinical investigation\| PubMed ID: 16100572	2005
The ICOS molecule plays a crucial role in the development of mucosal tolerance. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16301640	2005
Epileptic disorders : international epilepsy journal with videotape\| PubMed ID: 16338674	2005
Neurosurgical focus\| PubMed ID: 16398472	2005
Journal of autoimmunity\| PubMed ID: 16426816	2006
Induction of oral tolerization in CD86 deficient mice: a role for CD86 and B cells in the up-regulation of TGF-beta. Journal of autoimmunity\| PubMed ID: 16439314	2006
Neurosurgical focus\| PubMed ID: 16459994	2006
Journal of neuroimmunology\| PubMed ID: 16533538	2006
International immunology\| PubMed ID: 16540527	2006
Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16549802	2006
Annals of neurology\| PubMed ID: 16634007	2006
Nature reviews. Immunology\| PubMed ID: 16639431	2006
Nature\| PubMed ID: 16648838	2006
Pediatrics\| PubMed ID: 16651302	2006
Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16751425	2006
Journal of neuroimmunology\| PubMed ID: 16806500	2006
Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16887994	2006
Inflammation & allergy drug targets\| PubMed ID: 16918481	2006
Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16951385	2006
A model for the comprehensive investigation of a chronic autoimmune disease: the multiple sclerosis CLIMB study. Autoimmunity reviews\| PubMed ID: 17027888	2006
Clinical & developmental immunology\| PubMed ID: 17162357	2006
Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17182552	2007
Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17182553	2007
Cutting Edge: Immature human dendritic cells express latency-associated peptide and inhibit T cell activation in a TGF-beta-dependent manner. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17371954	2007
Natalizumab treatment for multiple sclerosis: recommendations for patient selection and monitoring. Lancet neurology\| PubMed ID: 17434098	2007
Diabetes\| PubMed ID: 17456848	2007
Epilepsia\| PubMed ID: 17484758	2007
Journal of the neurological sciences\| PubMed ID: 17521671	2007
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics\| PubMed ID: 17599713	2007
Epilepsy & behavior : E&B\| PubMed ID: 17613275	2007
What does the future hold for cell-based tolerogenic therapy? Nature reviews. Immunology\| PubMed ID: 17653127	2007
Neurosurgery\| PubMed ID: 17762730	2007
Nature immunology\| PubMed ID: 17994022	2007
Journal of autoimmunity\| PubMed ID: 18191540	2008
Epilepsia\| PubMed ID: 18226172	2008
Nature biotechnology\| PubMed ID: 18259174	2008
Journal of neurology\| PubMed ID: 18317671	2008
The Journal of clinical investigation\| PubMed ID: 18340379	2008
Annals of neurology\| PubMed ID: 18360829	2008
Nature\| PubMed ID: 18362915	2008
Journal of neuroimmunology\| PubMed ID: 18378324	2008
Increased IL-23 secretion and altered chemokine production by dendritic cells upon CD46 activation in patients with multiple sclerosis. Journal of neuroimmunology\| PubMed ID: 18403025	2008
Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 18490732	2008
Journal of cellular and molecular medicine\| PubMed ID: 18505469	2008
Brain : a journal of neurology\| PubMed ID: 18567923	2008
Glioma-like proliferation within tissues excised as tubers in patients with tuberous sclerosis complex. Acta neuropathologica\| PubMed ID: 18581125	2008
Neurosurgery\| PubMed ID: 18596454	2008
Lancet neurology\| PubMed ID: 18635014	2008
Neurosurgical focus\| PubMed ID: 18759614	2008
Journal of the neurological sciences\| PubMed ID: 18804221	2008
Nasal anti-CD3 antibody ameliorates lupus by inducing an IL-10-secreting CD4+ CD25- LAP+ regulatory T cell and is associated with down-regulation of IL-17+ CD4+ ICOS+ CXCR5+ follicular helpe... Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 18941193	2008
Nature reviews. Drug discovery\| PubMed ID: 18974749	2008
Predicting clinical progression in multiple sclerosis with the magnetic resonance disease severity scale. Archives of neurology\| PubMed ID: 19001162	2008
Increased osteopontin expression in dendritic cells amplifies IL-17 production by CD4+ T cells in experimental autoimmune encephalomyelitis and in multiple sclerosis. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 19017937	2008
Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19028871	2008
Journal of the American Statistical Association\| PubMed ID: 19081806	2007
Journal of autoimmunity\| PubMed ID: 19181483	2009
Deep gray matter involvement on brain MRI scans is associated with clinical progression in multiple sclerosis. Journal of neuroimaging : official journal of the American Society of Neuroimaging\| PubMed ID: 19192042	2009
Rate of brain atrophy in benign vs early multiple sclerosis. Archives of neurology\| PubMed ID: 19204160	2009
The role of the CD58 locus in multiple sclerosis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19237575	2009
NeuroImage\| PubMed ID: 19281850	2009
European journal of immunology\| PubMed ID: 19283716	2009
The challenge of multiple sclerosis: how do we cure a chronic heterogeneous disease? Annals of neurology\| PubMed ID: 19334069	2009
Pediatric neurosurgery\| PubMed ID: 19440004	2009
International immunology\| PubMed ID: 19515797	2009
Nature genetics\| PubMed ID: 19525953	2009
Journal of neurosurgery. Pediatrics\| PubMed ID: 19569916	2009
Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 19625647	2009
Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 19675171	2009
Nature immunology\| PubMed ID: 19684606	2009
Journal of clinical immunology\| PubMed ID: 19756989	2010
Epilepsy & behavior : E&B\| PubMed ID: 19767244	2009
European journal of immunology\| PubMed ID: 19768696	2009
Brain MRI lesion load at 1.5T and 3T versus clinical status in multiple sclerosis. Journal of neuroimaging : official journal of the American Society of Neuroimaging\| PubMed ID: 19888926	2011
Journal of neuroimmunology\| PubMed ID: 19931190	2010
The association between cognitive impairment and quality of life in patients with early multiple sclerosis. Journal of the neurological sciences\| PubMed ID: 19944429	2010
Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 20368276	2010
T and B cell hyperactivity and autoimmunity associated with niche-specific defects in apoptotic body clearance in TIM-4-deficient mice. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20368430	2010
Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20445103	2010
Epilepsia\| PubMed ID: 20491878	2010
Identification of an IL-27/osteopontin axis in dendritic cells and its modulation by IFN-gamma limits IL-17-mediated autoimmune inflammation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20534530	2010
Journal of neuroimmunology\| PubMed ID: 20580440	2010
Journal of neurosurgery. Pediatrics\| PubMed ID: 20672932	2010
Nature immunology\| PubMed ID: 20676092	2010
Nature immunology\| PubMed ID: 20676095	2010
Mucosal anti-CD3 monoclonal antibody attenuates collagen-induced arthritis that is associated with induction of LAP+ regulatory T cells and is enhanced by administration of an emulsome-based... Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 20720210	2010
Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 20720212	2010
Journal of immunological methods\| PubMed ID: 20837018	2010
Archives of neurology\| PubMed ID: 20837847	2010
Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery\| PubMed ID: 20853002	2011
Ocular immunology and inflammation\| PubMed ID: 20887202	2010
Annals of neurology\| PubMed ID: 21061396	2010
Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21068375	2010
Neurosurgery\| PubMed ID: 21099705	2011
Population structure and HLA DRB1 1501 in the response of subjects with multiple sclerosis to first-line treatments. Journal of neuroimmunology\| PubMed ID: 21115201	2011
PloS one\| PubMed ID: 21124798	2010
Nature medicine\| PubMed ID: 21131957	2011
A putative Alzheimer's disease risk allele in PCK1 influences brain atrophy in multiple sclerosis. PloS one\| PubMed ID: 21152065	2010
Epilepsy & behavior : E&B\| PubMed ID: 21288778	2011
Neurobiology of aging\| PubMed ID: 21371785	2012
Patient reported outcomes in benign multiple sclerosis. Multiple sclerosis (Houndmills, Basingstoke, England)\| PubMed ID: 21372114	2011
Journal of neurology, neurosurgery, and psychiatry\| PubMed ID: 21429902	2011
The relationship between normal cerebral perfusion patterns and white matter lesion distribution in 1,249 patients with multiple sclerosis. Journal of neuroimaging : official journal of the American Society of Neuroimaging\| PubMed ID: 21447022	2012
Journal of neurosurgery. Pediatrics\| PubMed ID: 21456917	2011
Oral tolerance. Immunological reviews\| PubMed ID: 21488901	2011
PloS one\| PubMed ID: 21494571	2011
Journal of neurosurgery. Pediatrics\| PubMed ID: 21631205	2011
Epilepsia\| PubMed ID: 21671922	2011
Immunobiology\| PubMed ID: 21676485	2011
Cognitive deterioration in patients with early multiple sclerosis: a 5-year study. Journal of neurology, neurosurgery, and psychiatry\| PubMed ID: 21746743	2012
Natalizumab treatment for multiple sclerosis: updated recommendations for patient selection and monitoring. Lancet neurology\| PubMed ID: 21777829	2011
Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 21788439	2011
In vivo induction of Tr1 cells via mucosal dendritic cells and AHR signaling. PloS one\| PubMed ID: 21886804	2011
Gut-tropic T cells that express integrin Î±4Î²7 and CCR9 are required for induction of oral immune tolerance in mice. Gastroenterology\| PubMed ID: 21925467	2011
European journal of immunology\| PubMed ID: 22002875	2012
PloS one\| PubMed ID: 22039443	2011
Induction of immunological tolerance by oral anti-CD3. Clinical & developmental immunology\| PubMed ID: 22162715	2012
Magnetic resonance disease severity scale (MRDSS) for patients with multiple sclerosis: a longitudinal study. Journal of the neurological sciences\| PubMed ID: 22209496	2012
Epilepsy control following intracranial monitoring without resection in young children. Epilepsia\| PubMed ID: 22242686	2012
IL-27 induction of IL-21 from human CD8+ T cells induces granzyme B in an autocrine manner. Immunology and cell biology\| PubMed ID: 22430249	2012
Journal of neurosurgery. Pediatrics\| PubMed ID: 22462706	2012
Journal of neurosurgery. Pediatrics\| PubMed ID: 22462708	2012
Journal of neuroimmunology\| PubMed ID: 22579051	2012
Glia\| PubMed ID: 22653784	2012
Immunological reviews\| PubMed ID: 22725961	2012
Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22745170	2012
PloS one\| PubMed ID: 22768094	2012
The short isoform of the CEACAM1 receptor in intestinal T cells regulates mucosal immunity and homeostasis via Tfh cell induction. Immunity\| PubMed ID: 23123061	2012
IFN-γ limits Th9-mediated autoimmune inflammation through dendritic cell modulation of IL-27. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 23125412	2012
Clinical relevance and functional consequences of the TNFRSF1A multiple sclerosis locus. Neurology\| PubMed ID: 24174586	2013
Brain MRI of nasal MOG therapeutic effect in relapsing-progressive EAE. Experimental neurology\| PubMed ID: 24552689	2014
In vivo anti-LAP mAb enhances IL-17/IFN-γ responses and abrogates anti-CD3-induced oral tolerance. International immunology\| PubMed ID: 25194146	2015
MicroRNA-21 promotes Th17 differentiation and mediates experimental autoimmune encephalomyelitis. The Journal of clinical investigation\| PubMed ID: 25642768	2015
MicroRNA-21, T helper lineage and autoimmunity. Oncotarget\| PubMed ID: 25991670	2015
Identification of a novel mechanism of action of fingolimod (FTY720) on human effector T cell function through TCF-1 upregulation. Journal of neuroinflammation\| PubMed ID: 26714756	2015
The Host Shapes the Gut Microbiota via Fecal MicroRNA. Cell host & microbe\| PubMed ID: 26764595	2016
Power estimation for non-standardized multisite studies. NeuroImage\| PubMed ID: 27039700	2016
Dysregulation of regulatory CD56(bright) NK cells/T cells interactions in multiple sclerosis. Journal of autoimmunity\| PubMed ID: 27157273	2016
IL-10-dependent Tr1 cells attenuate astrocyte activation and ameliorate chronic central nervous system inflammation. Brain : a journal of neurology\| PubMed ID: 27246324	2016
Mucosal administration of CD3-specific monoclonal antibody inhibits diabetes in NOD mice and in a preclinical mouse model transgenic for the CD3 epsilon chain. Journal of autoimmunity\| PubMed ID: 27745778	2017
Survivin controls biogenesis of microRNA in smokers: A link to pathogenesis of rheumatoid arthritis. Biochimica et biophysica acta. Molecular basis of disease\| PubMed ID: 27915033	2017
IL-6 Inhibits Upregulation of Membrane-Bound TGF-β 1 on CD4+ T Cells and Blocking IL-6 Enhances Oral Tolerance. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 28039301	2017
Targeting latency-associated peptide promotes antitumor immunity. Science immunology\| PubMed ID: 28763794	2017
History and mechanisms of oral tolerance. Seminars in immunology\| PubMed ID: 28774470	2017
A two-year study using cerebral gray matter volume to assess the response to fingolimod therapy in multiple sclerosis. Journal of the neurological sciences\| PubMed ID: 29146095	2017
Transcriptional signature of human pro-inflammatory T17 cells identifies reduced IL10 gene expression in multiple sclerosis. Nature communications\| PubMed ID: 29150604	2017
Microbiota Signaling Pathways that Influence Neurologic Disease. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics\| PubMed ID: 29340928	2018
Multiple Sclerosis: Mechanisms and Immunotherapy. Neuron\| PubMed ID: 29470968	2018
Microglial signatures and their role in health and disease. Nature reviews. Neuroscience\| PubMed ID: 30206328	2018
Acute microglia ablation induces neurodegeneration in the somatosensory system. Nature communications\| PubMed ID: 30385785	2018
The sex-specific interaction of the microbiome in neurodegenerative diseases. Brain research\| PubMed ID: 31419428	2019
Smad7 Controls Immunoregulatory PDL2/1-PD1 Signaling in Intestinal Inflammation and Autoimmunity. Cell reports\| PubMed ID: 31553906	2019
Oral Administration of miR-30d from Feces of MS Patients Suppresses MS-like Symptoms in Mice by Expanding Akkermansia muciniphila. Cell host & microbe\| PubMed ID: 31784260	2019
A One-Two Punch in the Gut May Trigger Multiple Sclerosis. Immunity\| PubMed ID: 33053328	2020