Michael Hudecek

Medizinische Klinik und Poliklinik II und Lehrstuhl für Zelluläre Immuntherapie, Universitätsklinikum Würzburg

Affiliated withUniversitätsklinikum Würzburg Außenstelle Würzburg Zelluläre Immuntherapie Universitätsklinikum Würzburg

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 4	Year
Publication title Cited by 7	2024
Publication title	2026
Publication title	2026
Publication title	2026

Other Publications

Article	Year
Myeloma CARs are rolling into the clinical arena. Blood\| PubMed ID: 27688779	2016
Targeted antibody-mediated depletion of murine CD19 CAR T cells permanently reverses B cell aplasia. The Journal of clinical investigation\| PubMed ID: 27760047	2016
Minicircle-Based Engineering of Chimeric Antigen Receptor (CAR) T Cells. Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer\| PubMed ID: 28101686	2016
Going non-viral: the Sleeping Beauty transposon system breaks on through to the clinical side. Critical reviews in biochemistry and molecular biology\| PubMed ID: 28402189	2017
Panobinostat induces CD38 upregulation and augments the antimyeloma efficacy of daratumumab. Blood\| PubMed ID: 28476749	2017
Mining Naïve Rabbit Antibody Repertoires by Phage Display for Monoclonal Antibodies of Therapeutic Utility. Journal of molecular biology\| PubMed ID: 28818634	2017
SLAMF7-CAR T cells eliminate myeloma and confer selective fratricide of SLAMF7 normal lymphocytes. Blood\| PubMed ID: 29089311	2017
CAR T-cells targeting FLT3 have potent activity against FLT3ITD AML and act synergistically with the FLT3-inhibitor crenolanib. Leukemia\| PubMed ID: 29472720	2018
Novel targets and technologies for CAR-T cells in multiple myeloma and acute myeloid leukemia. Current research in translational medicine\| PubMed ID: 29655962	2018
CARs and other T cell therapies for MM: The clinical experience. Best practice & research. Clinical haematology\| PubMed ID: 29909915	2018
Non-viral therapeutic cell engineering with the Sleeping Beauty transposon system. Current opinion in genetics & development\| PubMed ID: 29957586	2018
CAR T cells targeting αβ integrin are effective against advanced cancer in preclinical models. Advances in cell and gene therapy\| PubMed ID: 30420973	2018
Chimeric Antigen Receptor Library Screening Using a Novel NF-κB/NFAT Reporter Cell Platform. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 30573301	2019
Clinical Utilization of Chimeric Antigen Receptor T Cells in B Cell Acute Lymphoblastic Leukemia: An Expert Opinion from the European Society for Blood and Marrow Transplantation and the Ame... Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation\| PubMed ID: 30576834	2019
Clinical utilization of Chimeric Antigen Receptor T-cells (CAR-T) in B-cell acute lymphoblastic leukemia (ALL)-an expert opinion from the European Society for Blood and Marrow Transplantatio... Bone marrow transplantation\| PubMed ID: 31092900	2019
The tyrosine kinase inhibitor dasatinib acts as a pharmacologic on/off switch for CAR T cells. Science translational medicine\| PubMed ID: 31270272	2019
Super-resolution microscopy reveals ultra-low CD19 expression on myeloma cells that triggers elimination by CD19 CAR-T. Nature communications\| PubMed ID: 31316055	2019
ROR1-CAR T cells are effective against lung and breast cancer in advanced microphysiologic 3D tumor models. JCI insight\| PubMed ID: 31415244	2019
γ-Secretase inhibition increases efficacy of BCMA-specific chimeric antigen receptor T cells in multiple myeloma. Blood\| PubMed ID: 31558469	2019
A highly soluble Sleeping Beauty transposase improves control of gene insertion. Nature biotechnology\| PubMed ID: 31685959	2019
Management of adults and children undergoing chimeric antigen receptor T-cell therapy: best practice recommendations of the European Society for Blood and Marrow Transplantation (EBMT) and t... Haematologica\| PubMed ID: 31753925	2020
Antibody-Based CAR T Cells Produced by Lentiviral Transduction. Current protocols in immunology\| PubMed ID: 32150338	2020
β-. Journal for immunotherapy of cancer\| PubMed ID: 32303620	2020
Chemically Programmable and Switchable CAR-T Therapy. Angewandte Chemie (International ed. in English)\| PubMed ID: 32329959	2020
Upregulation of CD38 expression on multiple myeloma cells by novel HDAC6 inhibitors is a class effect and augments the efficacy of daratumumab. Leukemia\| PubMed ID: 32350373	2021
Inefficient CAR-proximal signaling blunts antigen sensitivity. Nature immunology\| PubMed ID: 32632291	2020
New targets and technologies for CAR-T cells. Current opinion in oncology\| PubMed ID: 32657796	2020
What is the future of immunotherapy in multiple myeloma? Blood\| PubMed ID: 32735639	2020
Overcoming key challenges in cancer immunotherapy with engineered T cells. Current opinion in oncology\| PubMed ID: 32796230	2020
Immune-based Therapies for Hematological Malignancies: An Update by the EHA SWG on Immunotherapy of Hematological Malignancies. HemaSphere\| PubMed ID: 32904089	2020
BATF3 programs CD8 T cell memory. Nature immunology\| PubMed ID: 32989328	2020
Immunocompetent cancer-on-chip models to assess immuno-oncology therapy. Advanced drug delivery reviews\| PubMed ID: 33798643	2021
Composite CD79A/CD40 co-stimulatory endodomain enhances CD19CAR-T cell proliferation and survival. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 33940156	2021
Microbial short-chain fatty acids modulate CD8 T cell responses and improve adoptive immunotherapy for cancer. Nature communications\| PubMed ID: 34210970	2021
Siglec-6 is a novel target for CAR T-cell therapy in acute myeloid leukemia. Blood\| PubMed ID: 34289026	2021
T-Cell Metabolism in Graft Host Disease. Frontiers in immunology\| PubMed ID: 34777373	2021
Publisher Correction: Upregulation of CD38 expression on multiple myeloma cells by novel HDAC6 inhibitors is a class effect and augments the efficacy of daratumumab. Leukemia\| PubMed ID: 34845317	2022
Current Limitations and Perspectives of Chimeric Antigen Receptor-T-Cells in Acute Myeloid Leukemia. Cancers\| PubMed ID: 34944782	2021
CD40- and 41BB-specific antibody fusion proteins with PDL1 blockade-restricted agonism. Theranostics\| PubMed ID: 35198053	2022
Time to evolve: predicting engineered T cell-associated toxicity with next-generation models. Journal for immunotherapy of cancer\| PubMed ID: 35577500	2022
Time 2EVOLVE: predicting efficacy of engineered T-cells - how far is the bench from the bedside? Journal for immunotherapy of cancer\| PubMed ID: 35577501	2022
The era of in vivo T cell engineering. Med (New York, N.Y.)\| PubMed ID: 35590210	2022
Toward Rapid, Widely Available Autologous CAR-T Cell Therapy - Artificial Intelligence and Automation Enabling the Smart Manufacturing Hospital. Frontiers in medicine\| PubMed ID: 35733863	2022
Highjacking myeloma's niche with beefed-up CAR-Ts. Blood\| PubMed ID: 35771562	2022
ROR1-targeting switchable CAR-T cells for cancer therapy. Oncogene\| PubMed ID: 35859167	2022
Automated, scaled, transposon-based production of CAR T cells. Journal for immunotherapy of cancer\| PubMed ID: 36096530	2022
CAR T cells targeting are effective at treating invasive pulmonary aspergillosis in preclinical models. Science translational medicine\| PubMed ID: 36170447	2022
Engineering CD20 CARs with a Twist. Cancer immunology research\| PubMed ID: 36633575	2023
All-trans retinoic acid works synergistically with the γ-secretase inhibitor crenigacestat to augment BCMA on multiple myeloma and the efficacy of BCMA-CAR T cells. Haematologica\| PubMed ID: 36722406	2023
Genome Editing in Engineered T Cells for Cancer Immunotherapy. Human gene therapy\| PubMed ID: 37694593	2023
Learning from the microbes: exploiting the microbiome to enforce T cell immunotherapy. Frontiers in immunology\| PubMed ID: 37799719	2023
BCMA CAR-T cells in multiple myeloma-ready for take-off? Leukemia & lymphoma\| PubMed ID: 37997705	2024
CAR T-cell therapy in multiple myeloma: mission accomplished? Blood\| PubMed ID: 38033289	2024
Accelerating development of engineered T cell therapies in the EU: current regulatory framework for studying multiple product versions and T2EVOLVE recommendations. Frontiers in immunology\| PubMed ID: 38077331	2023
Lymphodepletion - an essential but undervalued part of the chimeric antigen receptor T-cell therapy cycle. Frontiers in immunology\| PubMed ID: 38187393	2023
Trust in and Acceptance of Artificial Intelligence Applications in Medicine: Mixed Methods Study. JMIR human factors\| PubMed ID: 38231544	2024
Mutation-specific CAR T cells as precision therapy for IGLV3-21 expressing high-risk chronic lymphocytic leukemia. Nature communications\| PubMed ID: 38307904	2024
Correction: ROR1-targeting switchable CAR-T cells for cancer therapy. Oncogene\| PubMed ID: 38383728	2024
Breast cancer-on-chip for patient-specific efficacy and safety testing of CAR-T cells. Cell stem cell\| PubMed ID: 38754430	2024
Next-generation BCMA-targeted chimeric antigen receptor CARTemis-1: the impact of manufacturing procedure on CAR T-cell features. Cellular oncology (Dordrecht, Netherlands)\| PubMed ID: 39192092	2024
CAR-T cells and TRUCKs that recognize an EBNA-3C-derived epitope presented on HLA-B*35 control Epstein-Barr virus-associated lymphoproliferation. Journal for immunotherapy of cancer\| PubMed ID: 33127653	2020
Elotuzumab for the treatment of extramedullary myeloma: a retrospective analysis of clinical efficacy and SLAMF7 expression patterns. Annals of hematology\| PubMed ID: 33575947	2021
Cytotoxicity of CD19-CAR-NK92 cells is primarily mediated via perforin/granzyme pathway. Cancer immunology, immunotherapy : CII\| PubMed ID: 37052701	2023
TCR/CD3-based synthetic antigen receptors (TCC) convey superior antigen sensitivity combined with high fidelity of activation. Science advances\| PubMed ID: 39231214	2024
Metabolization of microbial postbiotic pentanoate drives anti-cancer CAR T cells. bioRxiv : the preprint server for biology\| PubMed ID: 39314273	2025
Optimizing CAR-T treatment: A TEVOLVE guide to raw and starting material selection. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 39533710	2025
Accelerating CAR-T Cell Therapies with Small-Molecule Inhibitors. BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy\| PubMed ID: 39589646	2025
Cellular Therapies for Multiple Myeloma: Engineering Hope. Cancers\| PubMed ID: 39594822	2024
Novel strategies to assess cytokine release mediated by chimeric antigen receptor T cells based on the adverse outcome pathway concept. Journal of immunotoxicology\| PubMed ID: 39655500	2024
Current Non-Viral-Based Strategies to Manufacture CAR-T Cells. International journal of molecular sciences\| PubMed ID: 39769449	2024
Short-Chain Fatty Acids Modulate Anti-ROR1 CAR T-Cell Function and Exhaustion in an Intestinal Adenocarcinoma-on-Chip Model. Advanced healthcare materials\| PubMed ID: 40249196	2025
European survey on CAR T-Cell analytical methods from apheresis to post-infusion immunomonitoring. Frontiers in immunology\| PubMed ID: 40342422	2025
Impact of Serum/Xeno-Free Medium and Cytokine Supplementation on CAR-T Cell Therapy Manufacturing in Stirred Tank Bioreactors. Biotechnology journal\| PubMed ID: 40923846	2025
Next-generation T cell immunotherapies engineered with CRISPR base and prime editing: challenges and opportunities. Nature reviews. Clinical oncology\| PubMed ID: 40973826	2025
Patient-reported outcomes in patients with hematologic malignancies treated with CAR T-cell therapy in Europe. Blood advances\| PubMed ID: 40991391	2025
ROR2-specific CAR T cells are effective against hematologic and solid tumors and well tolerated in mice. Cell reports. Medicine\| PubMed ID: 41056951	2025
Fine tuning towards the next generation of engineered T cells. Nature biomedical engineering\| PubMed ID: 41073806	2025
Call for preserving specialized knowledge and contributions of the CAT to advancing ATMPs in Europe. Cytotherapy\| PubMed ID: 41217312	2025
Endothelial dysfunction and proinflammatory state determine severe hematotoxicity and inferior outcome of CAR-T therapy. HemaSphere\| PubMed ID: 41368079	2025
Current capacity and gaps in viral vector manufacturing: a survey of centers associated with CTIWP of EBMT, NXTGEN-hightech, DARE-NL, T2EVOLVE, and GoCART coalition. Bone marrow transplantation\| PubMed ID: 41408458	2026
The European CAR-T map-Current status and future directions to improve access to CAR T-cell therapy for hematologic malignancies. HemaSphere\| PubMed ID: 41799248	2026
The German National Strategy for Gene- and Cell-Based Therapies: Generating Impact by Employing a Novel Multi-Stakeholder Approach. Human gene therapy\| PubMed ID: 42411062	2026
From monoclonal to polyfunctional immunotherapy: Reprogramming CAR-T-cell therapy with oncolytic viruses in B-cell malignancies. HemaSphere\| PubMed ID: 42416331	2026