Muthiah Manoharan

Alnylam Pharmaceuticals, Inc.

Affiliated withAlnylam Pharmaceuticals, Inc.

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 12	2012

Other Publications

Article	Year
A viral microRNA functions as an orthologue of cellular miR-155. Nature\| PubMed ID: 18075594	2007
The Journal of organic chemistry\| PubMed ID: 11798305	2002
Biochemistry\| PubMed ID: 11802733	2002
European journal of biochemistry / FEBS\| PubMed ID: 12027896	2002
Antisense & nucleic acid drug development\| PubMed ID: 12074364	2002
The Journal of pharmacology and experimental therapeutics\| PubMed ID: 12130724	2002
2'-O-[2-(methylthio)ethyl]-modified oligonucleotide: an analogue of 2'-O-[2-(methoxy)-ethyl]-modified oligonucleotide with improved protein binding properties and high binding affinity to ta... Biochemistry\| PubMed ID: 12269806	2002
Nature biotechnology\| PubMed ID: 12426578	2002
Improving antisense oligonucleotide binding to human serum albumin: dramatic effect of ibuprofen conjugation. Chembiochem : a European journal of chemical biology\| PubMed ID: 12465035	2002
High-affinity peptide nucleic acid oligomers containing tricyclic cytosine analogues. Organic letters\| PubMed ID: 12465896	2002
Angewandte Chemie (International ed. in English)\| PubMed ID: 12491456	2002
RNA (New York, N.Y.)\| PubMed ID: 12515389	2002
Bioconjugate chemistry\| PubMed ID: 12526688	2003
2'-O-[2-(amino)-2-oxoethyl] oligonucleotides. Organic letters\| PubMed ID: 12583729	2003
Journal of the American Chemical Society\| PubMed ID: 12603111	2003
Nucleic acids research\| PubMed ID: 12682357	2003
Organic letters\| PubMed ID: 12790517	2003
Organic letters\| PubMed ID: 12916967	2003
Evaluation of C-5 propynyl pyrimidine-containing oligonucleotides in vitro and in vivo. Antisense & nucleic acid drug development\| PubMed ID: 12954113	2003
Nucleic acids research. Supplement (2001)\| PubMed ID: 14510407	2003
Nucleic acids research\| PubMed ID: 14762210	2004
2'-O-[2-(guanidinium)ethyl]-modified oligonucleotides: stabilizing effect on duplex and triplex structures. Organic letters\| PubMed ID: 15176796	2004
Nucleic acids research\| PubMed ID: 15247346	2004
The journal of gene medicine\| PubMed ID: 15386737	2004
Nature\| PubMed ID: 15538359	2004
Journal of the American Chemical Society\| PubMed ID: 15547979	2004
Current opinion in chemical biology\| PubMed ID: 15556399	2004
Nucleic acids research\| PubMed ID: 15602001	2004
Methods in enzymology\| PubMed ID: 15644187	2005
Nature medicine\| PubMed ID: 15723075	2005
Probing the influence of stereoelectronic effects on the biophysical properties of oligonucleotides: comprehensive analysis of the RNA affinity, nuclease resistance, and crystal structure of... Biochemistry\| PubMed ID: 15966728	2005
Nucleic acids research\| PubMed ID: 16170156	2005
Journal of medicinal chemistry\| PubMed ID: 16220989	2005
Silencing of microRNAs in vivo with 'antagomirs'. Nature\| PubMed ID: 16258535	2005
Nature\| PubMed ID: 16565705	2006
Biochemistry\| PubMed ID: 16566588	2006
Journal of medicinal chemistry\| PubMed ID: 16610796	2006
Nature chemical biology\| PubMed ID: 17108989	2006
ACS chemical biology\| PubMed ID: 17163665	2006
Nucleosides, nucleotides & nucleic acids\| PubMed ID: 17365794	2007
Cell\| PubMed ID: 17382377	2007
Specificity, duplex degradation and subcellular localization of antagomirs. Nucleic acids research\| PubMed ID: 17439965	2007
Nature biotechnology\| PubMed ID: 17873866	2007
Nucleic acids research\| PubMed ID: 17881374	2007
Effective RNAi-mediated gene silencing without interruption of the endogenous microRNA pathway. Nature\| PubMed ID: 17898712	2007
Journal of medicinal chemistry\| PubMed ID: 18399648	2008
A combinatorial library of lipid-like materials for delivery of RNAi therapeutics. Nature biotechnology\| PubMed ID: 18438401	2008
Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18695239	2008
Oligonucleotides\| PubMed ID: 19093781	2009
Durable protection from Herpes Simplex Virus-2 transmission following intravaginal application of siRNAs targeting both a viral and host gene. Cell host & microbe\| PubMed ID: 19154990	2009
Development of lipidoid-siRNA formulations for systemic delivery to the liver. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 19259063	2009
Chemical communications (Cambridge, England)\| PubMed ID: 19333476	2009
Antimicrobial agents and chemotherapy\| PubMed ID: 19506055	2009
Rational design of cationic lipids for siRNA delivery. Nature biotechnology\| PubMed ID: 20081866	2010
Analytical biochemistry\| PubMed ID: 20156415	2010
Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 20170694	2010
Nucleic acids research\| PubMed ID: 20403811	2010
Organic letters\| PubMed ID: 20420425	2010
Targeted delivery of RNAi therapeutics with endogenous and exogenous ligand-based mechanisms. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 20461061	2010
Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20534471	2010
Analytical biochemistry\| PubMed ID: 20599656	2010
Nucleic acids research\| PubMed ID: 20610434	2010
Organic letters\| PubMed ID: 21049912	2010
Chemistry & biology\| PubMed ID: 21168770	2010
Nucleic acids research\| PubMed ID: 21183463	2011
The Journal of organic chemistry\| PubMed ID: 21299239	2011
Nucleic acids research\| PubMed ID: 21345934	2011
Angewandte Chemie (International ed. in English)\| PubMed ID: 21351337	2011
Bioconjugate chemistry\| PubMed ID: 21755983	2011
MicroRNA-194 is a target of transcription factor 1 (Tcf1, HNF1Î±) in adult liver and controls expression of frizzled-6. Hepatology (Baltimore, Md.)\| PubMed ID: 21887698	2012
Experimental neurology\| PubMed ID: 22119622	2012
Mechanistic insights into LDL nanoparticle-mediated siRNA delivery. Bioconjugate chemistry\| PubMed ID: 22142191	2012
RNA (New York, N.Y.)\| PubMed ID: 22294662	2012
Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery. Nature nanotechnology\| PubMed ID: 22659608	2012
Angewandte Chemie (International ed. in English)\| PubMed ID: 22782619	2012