rapid-isolation-viable-circulating-tumor-cells-from-patient-blood

Rapid Isolation of Viable Circulating Tumor Cells from Patient Blood Samples

Circulating tumor cells (CTC) are cells that disseminate from a primary tumor throughout the circulatory system and that can ultimately form secondary ...

Self-assembled nanostructures obtained from natural and synthetic amphiphiles serve as mimics of biological membranes and enable the delivery of drugs, proteins, genes, and imaging agents. Yet the precise molecular arrangements demanded by these functions are difficult to achieve. Libraries of amphiphilic Janus dendrimers, prepared by facile coupling of tailored hydrophilic and hydrophobic branched segments, have been screened by cryogenic transmission electron microscopy, revealing a rich palette of morphologies in water, including vesicles, denoted dendrimersomes, cubosomes, disks, tubular vesicles, and helical ribbons. Dendrimersomes marry the stability and mechanical strength obtainable from polymersomes with the biological function of stabilized phospholipid liposomes, plus superior uniformity of size, ease of formation, and chemical functionalization. This modular synthesis strategy provides access to systematic tuning of molecular structure and of self-assembled architecture.

Article	Year
Journal of the American Chemical Society\| PubMed ID: 14653716	2003
Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17420472	2007
Chemistry (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 18161712	2008
Self-assembly of Janus dendrimers into uniform dendrimersomes and other complex architectures. Science (New York, N.Y.)\| PubMed ID: 20489021	2010
Langmuir : the ACS journal of surfaces and colloids\| PubMed ID: 20557077	2010
Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology\| PubMed ID: 22162415	2012
Clinical chemistry\| PubMed ID: 22344286	2012
Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 22421423	2012

Andrew D. Hughes

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