Ralph Weissleder

Center for Systems Biology, Harvard Medical School

Affiliated withHarvard Medical School MGH - Massachusetts General Hospital Massachusetts General Hospital

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 3	Year
Publication title Cited by 15	2009
Publication title Cited by 9	2009
Publication title	2013

Other Publications

Article	Year
Would near-infrared fluorescence signals propagate through large human organs for clinical studies? Optics letters\| PubMed ID: 18007794	2002
Fast analytical approximation for arbitrary geometries in diffuse optical tomography. Optics letters\| PubMed ID: 18007854	2002
A fluorescent probe for the detection of myeloperoxidase activity in atherosclerosis-associated macrophages. Chemistry & biology\| PubMed ID: 18022561	2007
The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions. The Journal of experimental medicine\| PubMed ID: 18025128	2007
Would near-infrared fluorescence signals propagate through large human organs for clinical studies? Errata. Optics letters\| PubMed ID: 18026531	2002
Osteogenesis associates with inflammation in early-stage atherosclerosis evaluated by molecular imaging in vivo. Circulation\| PubMed ID: 18040026	2007
Effect of tumor microenvironment modulation on the efficacy of oncolytic virus therapy. Journal of the National Cancer Institute\| PubMed ID: 18042934	2007
A highly selective fluorescent probe for thiol bioimaging. Organic letters\| PubMed ID: 18062694	2008
Noninvasive imaging of apoptosis in cardiovascular disease. Heart failure reviews\| PubMed ID: 18074226	2008
Mast cells are an essential hematopoietic component for polyp development. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18077429	2007
Utility of a new bolus-injectable nanoparticle for clinical cancer staging. Neoplasia (New York, N.Y.)\| PubMed ID: 18084623	2007
Nanoparticle PET-CT imaging of macrophages in inflammatory atherosclerosis. Circulation\| PubMed ID: 18158358	2008
Noninvasive in vivo imaging of monocyte trafficking to atherosclerotic lesions. Circulation\| PubMed ID: 18172031	2008
A secreted luciferase for ex vivo monitoring of in vivo processes. Nature methods\| PubMed ID: 18204457	2008
Myeloperoxidase-targeted imaging of active inflammatory lesions in murine experimental autoimmune encephalomyelitis. Brain : a journal of neurology\| PubMed ID: 18234693	2008
Activatable magnetic resonance imaging agent reports myeloperoxidase activity in healing infarcts and noninvasively detects the antiinflammatory effects of atorvastatin on ischemia-reperfusi... Circulation\| PubMed ID: 18268141	2008
Transglutaminase activity in acute infarcts predicts healing outcome and left ventricular remodelling: implications for FXIII therapy and antithrombin use in myocardial infarction. European heart journal\| PubMed ID: 18276618	2008
A novel method of imaging calcium urolithiasis using fluorescence. The Journal of urology\| PubMed ID: 18295253	2008
Pilot study evaluating use of lymphotrophic nanoparticle-enhanced magnetic resonance imaging for assessing lymph nodes in renal cell cancer. Urology\| PubMed ID: 18295316	2008
Magnetic microparticle aggregation for viscosity determination by MR. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine\| PubMed ID: 18306403	2008
MR-optical imaging of cardiovascular molecular targets. Basic research in cardiology\| PubMed ID: 18324364	2008
Magnetic nanoparticles for MR imaging: agents, techniques and cardiovascular applications. Basic research in cardiology\| PubMed ID: 18324368	2008
Detection of early prostate cancer using a hepsin-targeted imaging agent. Cancer research\| PubMed ID: 18381435	2008
Imaging in the era of molecular oncology. Nature\| PubMed ID: 18385732	2008
Targeted nanoparticles for imaging incipient pancreatic ductal adenocarcinoma. PLoS medicine\| PubMed ID: 18416599	2008
Sensitive NMR sensors detect antibodies to influenza. Angewandte Chemie (International ed. in English)\| PubMed ID: 18428168	2008
Bimodal viral vectors and in vivo imaging reveal the fate of human neural stem cells in experimental glioma model. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 18434519	2008
Perturbational profiling of nanomaterial biologic activity. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18492802	2008
Multifunctional magnetic nanoparticles for targeted imaging and therapy. Advanced drug delivery reviews\| PubMed ID: 18508157	2008
Electrode chemistry yields a nanoparticle-based NMR sensor for calcium. Langmuir : the ACS journal of surfaces and colloids\| PubMed ID: 18558729	2008
Chip-NMR biosensor for detection and molecular analysis of cells. Nature medicine\| PubMed ID: 18607350	2008
Slow self-activation enhances the potency of viridin prodrugs. Journal of medicinal chemistry\| PubMed ID: 18630894	2008
In vivo quantitative microvasculature phenotype imaging of healthy and malignant tissues using a fiber-optic confocal laser microprobe. Translational oncology\| PubMed ID: 18633456	2008
Targeted imaging of myocardial damage. Nature clinical practice. Cardiovascular medicine\| PubMed ID: 18641609	2008
Human breast cancer tumor models: molecular imaging of drug susceptibility and dosing during HER2/neu-targeted therapy. Radiology\| PubMed ID: 18647846	2008
Near infrared fluorescence-based bacteriophage particles for ratiometric pH imaging. Bioconjugate chemistry\| PubMed ID: 18666791	2008
Noninvasive detection of macrophage-rich atherosclerotic plaque in hyperlipidemic rabbits using "positive contrast" magnetic resonance imaging. Journal of the American College of Cardiology\| PubMed ID: 18672170	2008
Live imaging of cysteine-cathepsin activity reveals dynamics of focal inflammation, angiogenesis, and polyp growth. PloS one\| PubMed ID: 18698347	2008
Off-resonance angiography: a new method to depict vessels--phantom and rabbit studies. Radiology\| PubMed ID: 18780823	2008
Integrated nanosensors to determine levels and functional activity of human telomerase. Neoplasia (New York, N.Y.)\| PubMed ID: 18813356	2008
Simplified syntheses of complex multifunctional nanomaterials. Chemical communications (Cambridge, England)\| PubMed ID: 18830495	2008
Real-time catheter molecular sensing of inflammation in proteolytically active atherosclerosis. Circulation\| PubMed ID: 18852366	2008
Regression of drug-resistant lung cancer by the combination of rosiglitazone and carboplatin. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 18927287	2008
Magnetic resonance imaging monitors physiological changes with antihedgehog therapy in pancreatic adenocarcinoma xenograft model. Pancreas\| PubMed ID: 18953259	2008
miR-296 regulates growth factor receptor overexpression in angiogenic endothelial cells. Cancer cell\| PubMed ID: 18977327	2008
Targeting multiple pathways in gliomas with stem cell and viral delivered S-TRAIL and Temozolomide. Molecular cancer therapeutics\| PubMed ID: 19001440	2008
Non-invasive optical detection of cathepsin K-mediated fluorescence reveals osteoclast activity in vitro and in vivo. Bone\| PubMed ID: 19007918	2009
Tracking the inflammatory response in stroke in vivo by sensing the enzyme myeloperoxidase. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19011099	2008
Early photon tomography allows fluorescence detection of lung carcinomas and disease progression in mice in vivo. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19015534	2008
Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers. Nature medicine\| PubMed ID: 19029981	2008
Real-time assessment of inflammation and treatment response in a mouse model of allergic airway inflammation. The Journal of clinical investigation\| PubMed ID: 19033674	2008
Tetrazine-based cycloadditions: application to pretargeted live cell imaging. Bioconjugate chemistry\| PubMed ID: 19053305	2008
Monofunctional carbocyanine dyes for bio- and bioorthogonal conjugation. Bioconjugate chemistry\| PubMed ID: 19053316	2008
A multifunctional single-attachment-point reagent for controlled protein biotinylation. Bioconjugate chemistry\| PubMed ID: 19072220	2009
BRAF activation initiates but does not maintain invasive prostate adenocarcinoma. PloS one\| PubMed ID: 19079609	2008
Design and demonstration of a small-animal up-conversion imager. Optics express\| PubMed ID: 19104605	2008
Improved detection of ovarian cancer metastases by intraoperative quantitative fluorescence protease imaging in a pre-clinical model. Gynecologic oncology\| PubMed ID: 19135233	2009
18F labeled nanoparticles for in vivo PET-CT imaging. Bioconjugate chemistry\| PubMed ID: 19138113	2009
Combined magnetic resonance and fluorescence imaging of the living mouse brain reveals glioma response to chemotherapy. NeuroImage\| PubMed ID: 19154791	2009
Normalized Born ratio for fluorescence optical projection tomography. Optics letters\| PubMed ID: 19183644	2009
Oncogenic EGFR signaling cooperates with loss of tumor suppressor gene functions in gliomagenesis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19196966	2009
Mutant sodium channel for tumor therapy. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 19259066	2009
Assessment of therapeutic efficacy and fate of engineered human mesenchymal stem cells for cancer therapy. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19264968	2009
Arterial and aortic valve calcification abolished by elastolytic cathepsin S deficiency in chronic renal disease. Circulation\| PubMed ID: 19307473	2009
Nanoparticle-target interactions parallel antibody-protein interactions. Analytical chemistry\| PubMed ID: 19323458	2009
Molecular imaging of innate immune cell function in transplant rejection. Circulation\| PubMed ID: 19332470	2009
Optical and multimodality molecular imaging: insights into atherosclerosis. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 19359659	2009
Heterogeneous in vivo behavior of monocyte subsets in atherosclerosis. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 19372462	2009
Genetically engineered T cells to target EGFRvIII expressing glioblastoma. Journal of neuro-oncology\| PubMed ID: 19387557	2009
Behavior of endogenous tumor-associated macrophages assessed in vivo using a functionalized nanoparticle. Neoplasia (New York, N.Y.)\| PubMed ID: 19412430	2009
Implantable diagnostic device for cancer monitoring. Biosensors & bioelectronics\| PubMed ID: 19442510	2009
Multimodal nanoagents for the detection of intravascular thrombi. Bioconjugate chemistry\| PubMed ID: 19456115	2009
Monocyte subset dynamics in human atherosclerosis can be profiled with magnetic nano-sensors. PloS one\| PubMed ID: 19461894	2009
The antiproliferative cytostatic effects of a self-activating viridin prodrug. Molecular cancer therapeutics\| PubMed ID: 19509266	2009
A stabilized demethoxyviridin derivative inhibits PI3 kinase. Bioorganic & medicinal chemistry letters\| PubMed ID: 19523825	2009
On the dual contrast enhancement mechanism in frequency-selective inversion-recovery magnetic resonance angiography (IRON-MRA). Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine\| PubMed ID: 19526511	2009
Efficacy of sunitinib and radiotherapy in genetically engineered mouse model of soft-tissue sarcoma. International journal of radiation oncology, biology, physics\| PubMed ID: 19545786	2009
Ultrasensitive detection of bacteria using core-shell nanoparticles and an NMR-filter system. Angewandte Chemie (International ed. in English)\| PubMed ID: 19554581	2009
Lymphotropic nanoparticle-enhanced magnetic resonance imaging (LNMRI) identifies occult lymph node metastases in prostate cancer patients prior to salvage radiation therapy. Clinical imaging\| PubMed ID: 19559353	2009
Nuclear microscopy: a novel technique for quantitative imaging of gadolinium distribution within tissue sections. Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada\| PubMed ID: 19575834	2009
Upconverting luminescent nanomaterials: application to in vivo bioimaging. Chemical communications (Cambridge, England)\| PubMed ID: 19585016	2009
A DNA-binding Gd chelate for the detection of cell death by MRI. Chemical communications (Cambridge, England)\| PubMed ID: 19597620	2009
Hybrid in vivo FMT-CT imaging of protease activity in atherosclerosis with customized nanosensors. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 19608968	2009
Synthesis and photophysical properties of sulfonamidophenyl porphyrins as models for activatable photosensitizers. The Journal of organic chemistry\| PubMed ID: 19610602	2009
Rapid detection and profiling of cancer cells in fine-needle aspirates. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19620715	2009
Identification of splenic reservoir monocytes and their deployment to inflammatory sites. Science (New York, N.Y.)\| PubMed ID: 19644120	2009
Abrogation of antibody-induced arthritis in mice by a self-activating viridin prodrug and association with impaired neutrophil and endothelial cell function. Arthritis and rheumatism\| PubMed ID: 19644878	2009
Enzyme-sensitive magnetic resonance imaging targeting myeloperoxidase identifies active inflammation in experimental rabbit atherosclerotic plaques. Circulation\| PubMed ID: 19652086	2009
High-yielding syntheses of hydrophilic conjugatable chlorins and bacteriochlorins. Organic & biomolecular chemistry\| PubMed ID: 19675897	2009
Fast and sensitive pretargeted labeling of cancer cells through a tetrazine/trans-cyclooctene cycloaddition. Angewandte Chemie (International ed. in English)\| PubMed ID: 19697389	2009
MRI of a novel murine working heart transplant model. Circulation. Heart failure\| PubMed ID: 19718275	2009
Transillumination fluorescence imaging in mice using biocompatible upconverting nanoparticles. Optics letters\| PubMed ID: 19724491	2009
Intravital molecular imaging of small-diameter tissue-engineered vascular grafts in mice: a feasibility study. Tissue engineering. Part C, Methods\| PubMed ID: 19751103	2010
Enhancing navigation in biomedical databases by community voting and database-driven text classification. BMC bioinformatics\| PubMed ID: 19799796	2009
Self-assembled multifunctional Fe/MgO nanospheres for magnetic resonance imaging and hyperthermia. Nanomedicine : nanotechnology, biology, and medicine\| PubMed ID: 19800988	2010
Oxazine conjugated nanoparticle detects in vivo hypochlorous acid and peroxynitrite generation. Journal of the American Chemical Society\| PubMed ID: 19817443	2009
Development of a Time Domain Fluorimeter for Fluorescent Lifetime Multiplexing Analysis. IEEE transactions on biomedical circuits and systems\| PubMed ID: 19830273	2008
18F-4V for PET-CT imaging of VCAM-1 expression in atherosclerosis. JACC. Cardiovascular imaging\| PubMed ID: 19833312	2009
Enhanced antitumor efficacy of vasculostatin (Vstat120) expressing oncolytic HSV-1. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 19844198	2010
Near-infrared fluorescence: application to in vivo molecular imaging. Current opinion in chemical biology\| PubMed ID: 19879798	2010
A wortmannin-cetuximab as a double drug. Bioconjugate chemistry\| PubMed ID: 19883074	2009
Molecular MRI of cardiomyocyte apoptosis with simultaneous delayed-enhancement MRI distinguishes apoptotic and necrotic myocytes in vivo: potential for midmyocardial salvage in acute ischemi... Circulation. Cardiovascular imaging\| PubMed ID: 19920044	2009
Molecular MRI detects low levels of cardiomyocyte apoptosis in a transgenic model of chronic heart failure. Circulation. Cardiovascular imaging\| PubMed ID: 19920045	2009
Notch signaling in cardiovascular disease and calcification. Current cardiology reviews\| PubMed ID: 19936191	2008
Multicolor fluorescent intravital live microscopy (FILM) for surgical tumor resection in a mouse xenograft model. PloS one\| PubMed ID: 19956597	2009
Activatable magnetic resonance imaging agents for myeloperoxidase sensing: mechanism of activation, stability, and toxicity. Journal of the American Chemical Society\| PubMed ID: 19968300	2010
Diffractionless beam in free space with adiabatic changing refractive index in a single mode tapered slab waveguide. Optics express\| PubMed ID: 19997414	2009
Unbiased discovery of in vivo imaging probes through in vitro profiling of nanoparticle libraries. Integrative biology : quantitative biosciences from nano to macro\| PubMed ID: 20023731	2009
Early identification of aortic valve sclerosis using iron oxide enhanced MRI. Journal of magnetic resonance imaging : JMRI\| PubMed ID: 20027578	2010
Binding affinity and kinetic analysis of targeted small molecule-modified nanoparticles. Bioconjugate chemistry\| PubMed ID: 20028085	2010
Intraoperative near-infrared fluorescent cholangiography (NIRFC) in mouse models of bile duct injury. World journal of surgery\| PubMed ID: 20033407	2010
High throughput transmission optical projection tomography using low cost graphics processing unit. Optics express\| PubMed ID: 20052155	2009
A novel molecule integrating therapeutic and diagnostic activities reveals multiple aspects of stem cell-based therapy. Stem cells (Dayton, Ohio)\| PubMed ID: 20127797	2010
The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha. Cell\| PubMed ID: 20141841	2010
Activin A promotes multiple myeloma-induced osteolysis and is a promising target for myeloma bone disease. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20194748	2010
Imaging primary lung cancers in mice to study radiation biology. International journal of radiation oncology, biology, physics\| PubMed ID: 20206017	2010
Bioorthogonal Turn-On Probes for Imaging Small Molecules inside Living Cells. Angewandte Chemie (International ed. in English)\| PubMed ID: 20306505	2010
Magnetic nanoparticle biosensors. Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology\| PubMed ID: 20336708	2010
Imaging of molecular probe activity with Born-normalized fluorescence optical projection tomography. Optics letters\| PubMed ID: 20364226	2010
Impaired infarct healing in atherosclerotic mice with Ly-6C(hi) monocytosis. Journal of the American College of Cardiology\| PubMed ID: 20378083	2010
Hybrid PET-optical imaging using targeted probes. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20385821	2010
Rapid biocompatibility analysis of materials via in vivo fluorescence imaging of mouse models. PloS one\| PubMed ID: 20386609	2010
The vascular biology of atherosclerosis and imaging targets. Journal of nuclear medicine : official publication, Society of Nuclear Medicine\| PubMed ID: 20395349	2010
Development of a bioorthogonal and highly efficient conjugation method for quantum dots using tetrazine-norbornene cycloaddition. Journal of the American Chemical Society\| PubMed ID: 20481508	2010
The phosphoinositide 3-kinase regulatory subunit p85alpha can exert tumor suppressor properties through negative regulation of growth factor signaling. Cancer research\| PubMed ID: 20530665	2010
Molecular imaging of atherosclerosis: a progress report. Texas Heart Institute journal / from the Texas Heart Institute of St. Luke's Episcopal Hospital, Texas Children's Hospital\| PubMed ID: 20548813	2010
MRI with magnetic nanoparticles monitors downstream anti-angiogenic effects of mTOR inhibition. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging\| PubMed ID: 20559742	2011
Myeloperoxidase-rich Ly-6C+ myeloid cells infiltrate allografts and contribute to an imaging signature of organ rejection in mice. The Journal of clinical investigation\| PubMed ID: 20577051	2010
Near-infrared fluorescent probe for imaging of pancreatic beta cells. Bioconjugate chemistry\| PubMed ID: 20583828	2010
Arterial and aortic valve calcification inversely correlates with osteoporotic bone remodelling: a role for inflammation. European heart journal\| PubMed ID: 20601388	2010
Intraoperative near-infrared fluorescent cholangiography (NIRFC) in mouse models of bile duct injury: reply. World journal of surgery\| PubMed ID: 20645091	2011
Bioorthogonal chemistry amplifies nanoparticle binding and enhances the sensitivity of cell detection. Nature nanotechnology\| PubMed ID: 20676091	2010
Pioglitazone suppresses inflammation in vivo in murine carotid atherosclerosis: novel detection by dual-target fluorescence molecular imaging. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 20689078	2010
A light-activated theranostic nanoagent for targeted macrophage ablation in inflammatory atherosclerosis. Small (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 20721949	2010
Quantitating antibody uptake in vivo: conditional dependence on antigen expression levels. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging\| PubMed ID: 20809210	2011
Targeted nanoagents for the detection of cancers. Molecular oncology\| PubMed ID: 20851695	2010
Quantitative nanostructure-activity relationship modeling. ACS nano\| PubMed ID: 20857979	2010
Carboxymethylated polyvinyl alcohol stabilizes doped ferrofluids for biological applications. Advanced materials (Deerfield Beach, Fla.)\| PubMed ID: 20859943	2010
In vivo imaging in cancer. Cold Spring Harbor perspectives in biology\| PubMed ID: 20861158	2010
Detection limits of intraoperative near infrared imaging for tumor resection. Journal of surgical oncology\| PubMed ID: 20872807	2010
Angiotensin-converting enzyme inhibition prevents the release of monocytes from their splenic reservoir in mice with myocardial infarction. Circulation research\| PubMed ID: 20930148	2010
High-resolution magnetic resonance imaging enhanced with superparamagnetic nanoparticles measures macrophage burden in atherosclerosis. Circulation\| PubMed ID: 20937980	2010
Self-assembled magnetic filter for highly efficient immunomagnetic separation. Lab on a chip\| PubMed ID: 20949198	2011
Bone marrow stromal cell transplants prevent experimental enterocolitis and require host CD11b+ splenocytes. Gastroenterology\| PubMed ID: 20955701	2011
Bioorthogonal small-molecule ligands for PARP1 imaging in living cells. Chembiochem : a European journal of chemical biology\| PubMed ID: 20967817	2010
Human embryonic stem cell-derived microvascular grafts for cardiac tissue preservation after myocardial infarction. Biomaterials\| PubMed ID: 21035182	2011
WNT5A/JNK and FGF/MAPK pathways regulate the cellular events shaping the vertebrate limb bud. Current biology : CB\| PubMed ID: 21055947	2010
Noninvasive imaging of pancreatic islet inflammation in type 1A diabetes patients. The Journal of clinical investigation\| PubMed ID: 21123946	2011
Dragon (repulsive guidance molecule b) inhibits IL-6 expression in macrophages. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 21187450	2011
High-Yielding, Two-Step (18)F Labeling Strategy for (18)F-PARP1 Inhibitors. ChemMedChem\| PubMed ID: 21207434	2011
Enhanced in vivo imaging of metabolically biotinylated cell surface reporters. Analytical chemistry\| PubMed ID: 21214190	2011
Detection of macrophages in aortic aneurysms by nanoparticle positron emission tomography-computed tomography. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 21252070	2011
Synthesis and in vivo imaging of a 18F-labeled PARP1 inhibitor using a chemically orthogonal scavenger-assisted high-performance method. Angewandte Chemie (International ed. in English)\| PubMed ID: 21328671	2011
Micro-NMR for rapid molecular analysis of human tumor samples. Science translational medicine\| PubMed ID: 21346169	2011
Probing intracellular biomarkers and mediators of cell activation using nanosensors and bioorthogonal chemistry. ACS nano\| PubMed ID: 21351804	2011
High-yielding, two-step 18F labeling strategy for 18F-PARP1 inhibitors. ChemMedChem\| PubMed ID: 21360818	2011
Molecular detection of biomarkers and cells using magnetic nanoparticles and diagnostic magnetic resonance. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 21424441	2011
Facile Synthesis of Monofunctional Pentamethine Carbocyanine Fluorophores. Dyes and pigments : an international journal\| PubMed ID: 21475610	2011
In vivo tomographic imaging of red-shifted fluorescent proteins. Biomedical optics express\| PubMed ID: 21483611	2011
Highly magnetic core-shell nanoparticles with a unique magnetization mechanism. Angewandte Chemie (International ed. in English)\| PubMed ID: 21495138	2011
Miniature magnetic resonance system for point-of-care diagnostics. Lab on a chip\| PubMed ID: 21547317	2011
Distinguishing inflammation from tumor and peritumoral edema by myeloperoxidase magnetic resonance imaging. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 21558403	2011
Report of the National Heart, Lung, and Blood Institute working group on the translation of cardiovascular molecular imaging. Circulation\| PubMed ID: 21576680	2011
Indocyanine green enables near-infrared fluorescence imaging of lipid-rich, inflamed atherosclerotic plaques. Science translational medicine\| PubMed ID: 21613624	2011
Biomedical applications of tetrazine cycloadditions. Accounts of chemical research\| PubMed ID: 21627112	2011
Dextran-coated iron oxide nanoparticles: a versatile platform for targeted molecular imaging, molecular diagnostics, and therapy. Accounts of chemical research\| PubMed ID: 21661727	2011
Two-dimensional intravascular near-infrared fluorescence molecular imaging of inflammation in atherosclerosis and stent-induced vascular injury. Journal of the American College of Cardiology\| PubMed ID: 21679853	2011
Analysis of mitosis and antimitotic drug responses in tumors by in vivo microscopy and single-cell pharmacodynamics. Cancer research\| PubMed ID: 21712408	2011
In vivo PET imaging of histone deacetylases by 18F-suberoylanilide hydroxamic acid (18F-SAHA). Journal of medicinal chemistry\| PubMed ID: 21721525	2011
Accurate measurement of pancreatic islet beta-cell mass using a second-generation fluorescent exendin-4 analog. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21768367	2011
Multiplexed magnetic labeling amplification using oligonucleotide hybridization. Advanced materials (Deerfield Beach, Fla.)\| PubMed ID: 21780311	2011
In vivo detection of Staphylococcus aureus endocarditis by targeting pathogen-specific prothrombin activation. Nature medicine\| PubMed ID: 21857652	2011
Modular strategy for the construction of radiometalated antibodies for positron emission tomography based on inverse electron demand Diels-Alder click chemistry. Bioconjugate chemistry\| PubMed ID: 21877749	2011
Bevacizumab with angiostatin-armed oHSV increases antiangiogenesis and decreases bevacizumab-induced invasion in U87 glioma. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 21915104	2012
A systems approach for tumor pharmacokinetics. PloS one\| PubMed ID: 21935441	2011
Bioorthogonal probes for polo-like kinase 1 imaging and quantification. Angewandte Chemie (International ed. in English)\| PubMed ID: 21948435	2011
Synthesis and evaluation of a series of 1,2,4,5-tetrazines for bioorthogonal conjugation. Bioconjugate chemistry\| PubMed ID: 21950520	2011
Multicore assemblies potentiate magnetic properties of biomagnetic nanoparticles. Advanced materials (Deerfield Beach, Fla.)\| PubMed ID: 21953810	2011
Nanoparticle-mediated measurement of target-drug binding in cancer cells. ACS nano\| PubMed ID: 21962084	2011
Ubiquitous detection of gram-positive bacteria with bioorthogonal magnetofluorescent nanoparticles. ACS nano\| PubMed ID: 21967150	2011
Magnetic nanoparticles for biomedical NMR-based diagnostics. Beilstein journal of nanotechnology\| PubMed ID: 21977404	2010
Therapeutic siRNA silencing in inflammatory monocytes in mice. Nature biotechnology\| PubMed ID: 21983520	2011
Different capacity of monocyte subsets to phagocytose iron-oxide nanoparticles. PloS one\| PubMed ID: 21984904	2011
89Zr-labeled dextran nanoparticles allow in vivo macrophage imaging. Bioconjugate chemistry\| PubMed ID: 22035047	2011
Specific pathogen detection using bioorthogonal chemistry and diagnostic magnetic resonance. Bioconjugate chemistry\| PubMed ID: 22043803	2011
Interview: Nanomedicine in oncology: miniaturized means to an enormous end. Interviewed by Cara Sutton. Nanomedicine (London, England)\| PubMed ID: 22077461	2011
Vasculitis: molecular imaging by targeting the inflammatory enzyme myeloperoxidase. Radiology\| PubMed ID: 22084204	2012
Supramolecular Host-Guest Interaction for Labeling and Detection of Cellular Biomarkers. Angewandte Chemie (International ed. in English)\| PubMed ID: 22113923	2011
Intravital imaging. Cell\| PubMed ID: 22118457	2011
Extramedullary Hematopoiesis Generates Ly-6Chigh Monocytes That Infiltrate Atherosclerotic Lesions. Circulation\| PubMed ID: 22144566	2012
Bioorthogonal reaction pairs enable simultaneous, selective, multi-target imaging. Angewandte Chemie (International ed. in English)\| PubMed ID: 22162316	2012
Rapid monocyte kinetics in acute myocardial infarction are sustained by extramedullary monocytopoiesis. The Journal of experimental medicine\| PubMed ID: 22213805	2012
PET/MRI of inflammation in myocardial infarction. Journal of the American College of Cardiology\| PubMed ID: 22222080	2012
Innate response activator B cells protect against microbial sepsis. Science (New York, N.Y.)\| PubMed ID: 22245738	2012
Magnetic Nanoparticles and microNMR for Diagnostic Applications. Theranostics\| PubMed ID: 22272219	2012
Origins of tumor-associated macrophages and neutrophils. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22308361	2012
The neuropeptide neuromedin U promotes autoantibody-mediated arthritis. Arthritis research & therapy\| PubMed ID: 22314006	2012
Development of Secreted Protein and Acidic and Rich in Cysteine (SPARC) Targeted Nanoparticles for the Prognostic Molecular Imaging of Metastatic Prostate Cancer. Journal of nanomedicine & nanotechnology\| PubMed ID: 22319675	2011
Multifunctional nanoagent for thrombus-targeted fibrinolytic therapy. Nanomedicine (London, England)\| PubMed ID: 22348271	2012
Early window of diabetes determinism in NOD mice, dependent on the complement receptor CRIg, identified by noninvasive imaging. Nature immunology\| PubMed ID: 22366893	2012
Single reporter for targeted multimodal in vivo imaging. Journal of the American Chemical Society\| PubMed ID: 22397453	2012
Reactive polymer enables efficient in vivo bioorthogonal chemistry. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22411831	2012
Orthogonal amplification of nanoparticles for improved diagnostic sensing. ACS nano\| PubMed ID: 22424443	2012
Demyelinating diseases: myeloperoxidase as an imaging biomarker and therapeutic target. Radiology\| PubMed ID: 22438365	2012
Synthesis of [18F]BODIPY: bifunctional reporter for hybrid optical/positron emission tomography imaging. Angewandte Chemie (International ed. in English)\| PubMed ID: 22473535	2012
Imaging therapeutic PARP inhibition in vivo through bioorthogonally developed companion imaging agents. Neoplasia (New York, N.Y.)\| PubMed ID: 22496617	2012
Establishment and characterization of a novel chordoma cell line: CH22. Journal of orthopaedic research : official publication of the Orthopaedic Research Society\| PubMed ID: 22504929	2012
In vivo imaging of drug-induced mitochondrial outer membrane permeabilization at single-cell resolution. Cancer research\| PubMed ID: 22505651	2012
Mapping molecular agents distributions in whole mice hearts using born-normalized optical projection tomography. PloS one\| PubMed ID: 22509302	2012
Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism. Cell\| PubMed ID: 22541435	2012
Regulation of monocyte functional heterogeneity by miR-146a and Relb. Cell reports\| PubMed ID: 22545247	2012
Bioorthogonal imaging of aurora kinase A in live cells. Angewandte Chemie (International ed. in English)\| PubMed ID: 22644700	2012
Molecular imaging of fibrin deposition in deep vein thrombosis using fibrin-targeted near-infrared fluorescence. JACC. Cardiovascular imaging\| PubMed ID: 22698530	2012
Notch ligand delta-like 4 blockade attenuates atherosclerosis and metabolic disorders. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22699504	2012
A magnetic Gram stain for bacterial detection. Angewandte Chemie (International ed. in English)\| PubMed ID: 22744868	2012
Sensitive and direct detection of circulating tumor cells by multimarker Âµ-nuclear magnetic resonance. Neoplasia (New York, N.Y.)\| PubMed ID: 22745585	2012
Mechanism of magnetic relaxation switching sensing. ACS nano\| PubMed ID: 22762250	2012
Myocardial infarction accelerates atherosclerosis. Nature\| PubMed ID: 22763456	2012
Ultrasensitive clinical enumeration of rare cells ex vivo using a micro-hall detector. Science translational medicine\| PubMed ID: 22764208	2012
CT322, a VEGFR-2 antagonist, demonstrates anti-glioma efficacy in orthotopic brain tumor model as a single agent or in combination with temozolomide and radiation therapy. Journal of neuro-oncology\| PubMed ID: 22875706	2012
Noise suppressed, multifocus image fusion for enhanced intraoperative navigation. Journal of biophotonics\| PubMed ID: 22887724	2013
Optochemogenetics (OCG) allows more precise control of genetic engineering in mice with CreER regulators. Bioconjugate chemistry\| PubMed ID: 22917215	2012
Real-time in vivo imaging of the beating mouse heart at microscopic resolution. Nature communications\| PubMed ID: 22968700	2012
Inflammation modulates murine venous thrombosis resolution in vivo: assessment by multimodal fluorescence molecular imaging. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 22995524	2012
Dual imaging and photoactivated nanoprobe for controlled cell tracking. Small (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 22996932	2013
Modeling biological activities of nanoparticles. Nano letters\| PubMed ID: 23039907	2012
Improved intravital microscopy via synchronization of respiration and holder stabilization. Journal of biomedical optics\| PubMed ID: 23085919	2012
Photocleavable DNA barcode-antibody conjugates allow sensitive and multiplexed protein analysis in single cells. Journal of the American Chemical Society\| PubMed ID: 23092113	2012
Protein typing of circulating microvesicles allows real-time monitoring of glioblastoma therapy. Nature medicine\| PubMed ID: 23142818	2012
Implantable microenvironments to attract hematopoietic stem/cancer cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23150542	2012
Selective factor XIIa inhibition attenuates silent brain ischemia: application of molecular imaging targeting coagulation pathway. JACC. Cardiovascular imaging\| PubMed ID: 23153913	2012
Microfluidic cell sorter (Î¼FCS) for on-chip capture and analysis of single cells. Advanced healthcare materials\| PubMed ID: 23184773	2012
The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism. Cell\| PubMed ID: 23217706	2012
Painting blood vessels and atherosclerotic plaques with an adhesive drug depot. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23236189	2012
Polymeric nanoparticle PET/MR imaging allows macrophage detection in atherosclerotic plaques. Circulation research\| PubMed ID: 23300273	2013
Angiotensin II Drives the Production of Tumor-Promoting Macrophages. Immunity\| PubMed ID: 23333075	2013
Systemic RNAi-mediated Gene Silencing in Nonhuman Primate and Rodent Myeloid Cells. Molecular therapy. Nucleic acids\| PubMed ID: 23344621	2012
Single-cell and subcellular pharmacokinetic imaging allows insight into drug action in vivo. Nature communications\| PubMed ID: 23422672	2013
Nano-SAR development for bioactivity of nanoparticles with considerations of decision boundaries. Small (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 23423856	2013
Î¼Hall Chip for Sensitive Detection of Bacteria. Advanced healthcare materials\| PubMed ID: 23495188	2013
Comparison of select cancer biomarkers in human circulating and bulk tumor cells using magnetic nanoparticles and a miniaturized micro-NMR system. Nanomedicine : nanotechnology, biology, and medicine\| PubMed ID: 23570873	2013
Fluorescence endoscopy of cathepsin activity discriminates dysplasia from colitis. Inflammatory bowel diseases\| PubMed ID: 23591598	2013
Single cell analysis of drug distribution by intravital imaging. PloS one\| PubMed ID: 23593370	2013
Upconverting organic dye doped core-shell nano-composites for dual-modality NIR imaging and photo-thermal therapy. Theranostics\| PubMed ID: 23606913	2013
Magnetic barcode assay for genetic detection of pathogens. Nature communications\| PubMed ID: 23612293	2013
Monocyte-directed RNAi targeting CCR2 improves infarct healing in atherosclerosis-prone mice. Circulation\| PubMed ID: 23616627	2013
A magneto-DNA nanoparticle system for rapid detection and phenotyping of bacteria. Nature nanotechnology\| PubMed ID: 23644570	2013
A Pretargeted PET Imaging Strategy Based on Bioorthogonal Diels-Alder Click Chemistry. Journal of nuclear medicine : official publication, Society of Nuclear Medicine\| PubMed ID: 23708196	2013
BODIPY-tetrazine derivatives as superbright bioorthogonal turn-on probes. Angewandte Chemie (International ed. in English)\| PubMed ID: 23712730	2013
Nanoparticle PET-CT detects rejection and immunomodulation in cardiac allografts. Circulation. Cardiovascular imaging\| PubMed ID: 23771986	2013
Targeting cathepsin E in pancreatic cancer by a small molecule allows in vivo detection. Neoplasia (New York, N.Y.)\| PubMed ID: 23814481	2013
Miniaturized nuclear magnetic resonance platform for detection and profiling of circulating tumor cells. Lab on a chip\| PubMed ID: 23835814	2013
Local proliferation dominates lesional macrophage accumulation in atherosclerosis. Nature medicine\| PubMed ID: 23933982	2013
Bioorthogonal Approach to Identify Unsuspected Drug Targets in Live Cells. Angewandte Chemie (International ed. in English)\| PubMed ID: 23960025	2013
Efficient (18)F-Labeling of Synthetic Exendin-4 Analogues for Imaging Beta Cells. ChemistryOpen\| PubMed ID: 23997998	2012