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Study design and reporting
This systematic review and meta-analysis was conducted to evaluate the effectiveness of simulation-based learning (SBL) for emergency preparedness and response in nursing education, with a particular focus on gastrointestinal (GI)-related emergency scenarios. The objective was to synthesize standardized effect sizes across six predefined learning domains: knowledge acquisition, skill performance, teamwork ability, clinical thinking, professional responsibility, and self-confidence. The review was conducted and reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines10.
Data sources and search strategy
The literature search involved a systematic search in PubMed, Scopus, Web of Science, and Embase. A combination of controlled vocabulary terms and free-text keywords was used, including nursing, simulation-based learning, emergency or acute care, and gastrointestinal conditions. Boolean operators were applied to improve precision (e.g., “nursing” AND “simulation” AND “emergency” AND (“gastrointestinal” OR “GI bleeding” OR “abdominal pain”)). In addition, manual screening of reference lists from eligible studies was performed to identify any further relevant articles.
The search covered all records available in the selected databases from inception to March 2026. Complete database-specific search strategies, including keywords, Boolean operators, and search filters, are provided in Supplementary Table 1.
The initial database search identified 540 records. After removing 180 duplicate records, 360 articles were screened based on title and abstract. Of these, 300 records were excluded due to irrelevance. Sixty full-text articles were assessed for eligibility, of which 52 were excluded (28 due to insufficient quantitative data and 24 due to full-text unavailability or non-English language). A total of eight studies met all eligibility criteria and were included in the final systematic review and exploratory quantitative synthesis. Two reviewers independently screened titles and abstracts, followed by full-text assessment of potentially eligible studies. Disagreements regarding study eligibility were resolved through discussion and consensus.
Eligibility criteria
Studies were included if they enrolled nursing students or practicing nurses and evaluated simulation-based learning interventions targeting emergency response. Eligible studies involved either gastrointestinal-focused simulation scenarios or broader emergency nursing simulation programs with relevance to gastrointestinal assessment, management, procedures, or patient care. Comparator groups included lecture-based instruction, standard teaching, or routine clinical training. Studies were required to report extractable post-intervention outcome data for at least one predefined domain, including knowledge, skill performance, teamwork ability, clinical thinking, professional responsibility, or self-confidence. Randomized controlled trials, quasi-experimental studies, and other controlled comparative designs were eligible for inclusion.
Data extraction and outcome harmonization
Two reviewers independently extracted data using a standardized extraction form. Extracted information included author name, year of publication, country, study design, sample size, participant characteristics, details of the simulation intervention and comparator, and reported outcome measures. Quantitative data included post-intervention means, standard deviations, and sample sizes for each study group.
Outcome measures were categorized into six predefined domains: knowledge acquisition, skill performance, teamwork ability, clinical thinking, professional responsibility, and self-confidence. Most outcomes were directly assigned according to the definitions reported in the original studies. In a small number of cases, outcomes reported under alternative labels were reclassified according to their primary educational construct to improve comparability across studies. Classification decisions were independently reviewed by two investigators and resolved through consensus. This harmonization procedure was based on established frameworks for the meta-analytic synthesis of educational outcomes11. Although this approach improved consistency across studies, some degree of conceptual overlap or outcome misclassification cannot be completely excluded. The rationale for all reclassified outcomes is provided in Supplementary Table 2.
Effect size calculation
Standardized mean differences were calculated as Hedges’ g with corresponding 95% confidence intervals (CIs) for each outcome. Hedges’ g was selected to correct for small-sample bias and is appropriate for synthesizing continuous outcomes measured using different instruments12. When necessary, reported statistics were converted to standardized mean differences using standard formulae.
Statistical analysis and data synthesis
Random-effects models were used to compute pooled effects to account for both within-study and between-study variation. To obtain more conservative and reliable confidence intervals, especially when the meta-analysis is done based on a small number of studies, Restricted Maximum Likelihood (REML) estimation with Knapp–Hartung adjustment was used. To determine statistical heterogeneity, the Cochran Q statistic, τ2 (between-study variance), and I2 statistic, which measures the extent of total variation due to heterogeneity and not sampling error, were used. I2 values that were greater than 75% were considered to imply a great degree of heterogeneity.
Forest plots were generated to visually display individual study effect sizes and pooled estimates across outcome domains. The robustness of pooled results was investigated by sensitivity analyses to omit studies that had unclear methodological characteristics. Subgroup analyses were performed based on study design (randomized vs quasi-experimental) and simulation fidelity (high vs low), where data permitted. All statistical analyses were performed using R software (version 4.3.1) with the metafor package. A two-sided p-value < 0.05 was considered statistically significant.
Publication bias assessment
Funnel plots were used to assess visual evidence of publication bias and small-study effects, and the Egger regression test was used to assess statistical evidence of this effect. The Egger test was used to assess funnel plot asymmetry, in which the standardized effect size was regressed on its standard error; a significant intercept indicated the presence of publication bias13. The funnel plot asymmetry was viewed with caution, since it can also be caused by substantial heterogeneity or methodological fluctuations rather than selective publication14.
Risk of bias and certainty of evidence
Each study included was evaluated for risk of bias using a modified ROBINS-I framework. A modified ROBINS-I framework was applied to accommodate educational intervention studies. The assessment evaluated bias arising from participant selection, intervention classification, missing outcome data, outcome measurement, and selective reporting. Domains relating to deviations from intended interventions were simplified because the included studies primarily involved educational rather than clinical interventions. Risk-of-bias assessments varied across methodological domains (Table 1). Most studies demonstrated low risk of incomplete outcome data and selective reporting; however, moderate concerns were frequently identified regarding participant selection, allocation procedures, and blinding due to the educational nature of the interventions. Overall, most studies were judged to have a moderate risk of bias, whereas the prospective validation study by Nielsen et al. demonstrated a lower overall risk profile. The confidence in all the evidence for each outcome domain was assessed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach, which considers limitations of the studies, inconsistency, imprecision, and indirectness (Table 2).